Toxic effects of zearalenone on gametogenesis and embryonic development: A molecular point of review

Yang, Duomeng; Jiang, Xinwei; Sun, Jianxia; Li, Xia; Liu, Xusheng; Jiao, Rui; Peng, Ziyao; Li, Yuqi; Bai, Weibin

doi:10.1016/j.fct.2018.06.003

Cited by 75 publications

(54 citation statements)

References 70 publications

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“…Zearalenone (ZEA) is a non‐steroidal, oestrogenic metabolite of Fusarium fungi (Belhassen et al, ; Othmen, Golli, Abidessefi, & Bacha, ). Zearalenone and its derivatives are widely distributed in rice, wheat and other crops, and these residues in meat and dairy products could pose health risks to humans (Mauro et al, ; Yang et al, ). Studies have shown that the strong oestrogenic and anabolic activities of ZEA induced serious alterations in the reproductive system of laboratory animals and farm livestock such as vulvar swelling, mammary glands hyperplasia, uterine enlargement, and even uterine, vaginal and rectal prolapse (Belli et al, ; Hewitt, Girgis, Brash, & Smith, ; Jiang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of stress response, growth and development of uteri in post‐weaning gilts challenged with zearalenone and estradiol benzoate

Zhou

Yang

Chen

et al. 2019

Animal Physiology Nutrition

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The objective of this study was to evaluate the effects of zearalenone (ZEA) and estradiol benzoate (EB) on stress injury and uterine development in post‐weaning gilts. Thirty healthy post‐weaning female gilts (Duroc × Landrace × Large White) aged 28–32 days were randomly allocated to three treatments as follows: (a) basal diet (Control), (b) basal diet plus 1.0 mg/kg purified ZEA (ZEA) and (c) basal diet plus 0.75 ml (1.5 mg) EB per pig at 3‐days intervals by intramuscular injection (EB). The serum estradiol (E2), the final and the increased vulvar area, uterine index, thickness of the myometrium and endometrium, and protein expression of heat shock protein 70 (HSP70) in ZEA group were higher than those in the control group (p < .05), but lower than those in the EB group (p < .05). The serum luteinizing hormone in ZEA group was lower than that of the control group (p < .05), but higher than that in the EB group (p < .05). Higher serum follicle‐stimulating hormone and progesterone were observed in the ZEA and control groups than those in the EB group (p < .05). The serum glutathione peroxidase activity in the ZEA group was lower than that in the control and EB groups (p < .001), and the malondialdehyde in the ZEA group was higher than that in the control and EB groups (p < .001). Moreover, the relative mRNA and protein expression of growth hormone receptor (GHR) and relative mRNA expression of HSP70 in the ZEA and EB groups were higher than those in the control group (p < .05). In conclusion, both ZEA (1.0 mg/kg) and EB (1.5 mg at 3 days intervals by intramuscular injection) stimulated vulvar swelling and uterine hypertrophy by disordering serum hormones and up‐regulating GHR expression, and induced stress by different mechanisms in this study. Furthermore, the observed up‐regulating HSP70 expression challenged by ZEA or EB may be part of the mechanism to resist stress injury.

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Section: Introductionmentioning

confidence: 99%

Comparative study of stress response, growth and development of uteri in post‐weaning gilts challenged with zearalenone and estradiol benzoate

Zhou

Yang

Chen

et al. 2019

Animal Physiology Nutrition

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“…Zearalenone has been found to be toxic to male reproductive functions especially spermatogenesis process . Our previous study demonstrated that exposure to low‐dose ZEA (lower than NOEL) diminished semen quality, disrupted spermatogenesis and increased germ cell DNA‐DSBs .…”

Section: Discussionmentioning

confidence: 99%

“…Zearalenone (ZEA), a F‐2 mycotoxin produced by Fusarium , has been found to be an endocrine disruptor through oestrogen receptor signalling pathway to impair the reproductive systems . It has been found that ZEA can damage both female and male reproductive systems in different animal models and also the adverse effects can be transgenerational to the future generations …”

Section: Introductionmentioning

confidence: 99%

“…ZEA exposure diminished spermatogenic cells and increased DNA double‐stand break (DSB) in spermatogenic cells . There are a few mechanisms that have been proposed for ZEA‐induced toxicity in male reproductive systems . Acting as an oestrogen‐like compound, ZEA can bind to oestrogen receptor which results in damage to germ cells and testicular structure .…”

Section: Introductionmentioning

confidence: 99%

“…10 There are a few mechanisms that have been proposed for ZEA-induced toxicity in male reproductive systems. 5,8,11 Acting as an oestrogen-like compound, ZEA can bind to oestrogen receptor which results in damage to germ cells and testicular structure. 6,12,13 It has been found that the blood-testis barrier was disrupted by ZEA to cause the germ cell damage.…”

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confidence: 99%

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Gestational exposure to low‐dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications

Men

Zhao

Zhang

et al. 2019

Basic Clin Pharma Tox

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Zearalenone (ZEA), a F‐2 mycotoxin produced by Fusarium, has been found to be an endocrine disruptor through oestrogen receptor signalling pathway to impair spermatogenesis. The disruption on reproductive systems by ZEA exposure might be transgenerational. In our previous report, we have found that low dose (lower than no‐observed effect level, NOEL) of ZEA impaired mouse spermatogenesis and decreased mouse semen quality. The purpose of the current investigation was to explore the impacts of low‐dose ZEA on spermatogenesis in the offspring after prenatal exposure and the underlying mechanisms. And it demonstrated that prenatal low‐dose ZEA exposure disrupted the meiosis process to inhibit the spermatogenesis in offspring and even to diminish the semen quality by the decrease in spermatozoa motility and concentration. The DNA methylation marker 5hmC was decreased, the histone methylation markers H3K9 and H3K27 were elevated, and oestrogen receptor alpha was reduced in the offspring testis after prenatal low‐dose ZEA exposure. The data suggest that the disruption in spermatogenesis by prenatal low‐dose ZEA exposure may be through the modifications on epigenetic pathways (DNA methylation and histone methylation) and the interactions with oestrogen receptor signalling pathway. Moreover, in the current study, the male offspring were indirectly exposed to low‐dose ZEA through placenta and the spermatogenesis in offspring was disrupted which suggested that the toxicity of ZEA on reproductive systems was very severe. Therefore, we strongly recommend that greater attention should be paid to this mycotoxin to minimize its adverse impact on human spermatogenesis.

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Recent trends in fluorescent aptasensors for mycotoxin detection in food: Principles, constituted elements, types, and applications

Yan

Chen

et al. 2022

Food Frontiers

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Mycotoxins are the secondary metabolites of fungi in food and can be toxic to people. Therefore, developing simple, sensitive, and specific detection methods to detect mycotoxins in food is essential for ensuring food safety. Fluorescent aptasensors for the detection of mycotoxins in food have developed rapidly. They are simple and fast with high affinity and specificity. However, fluorescent aptasensors have not yet been applied in officially approved standards so far. This review elucidates fluorescent aptasensors for mycotoxin detection, including principles, constituted elements, types, and applications. Screening results of aptamers and each aptamer sequence used in fluorescent aptasensors are summarized to facilitate further research for later studies.We also focused on fluorescent probes, nanomaterials, and other strategies in the process of constructing fluorescent aptasensors. We then discuss current challenges and future perspectives in fluorescent aptasensors for mycotoxin detection.

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Toxic effects of zearalenone on gametogenesis and embryonic development: A molecular point of review

Cited by 75 publications

References 70 publications

Comparative study of stress response, growth and development of uteri in post‐weaning gilts challenged with zearalenone and estradiol benzoate

Comparative study of stress response, growth and development of uteri in post‐weaning gilts challenged with zearalenone and estradiol benzoate

Gestational exposure to low‐dose zearalenone disrupting offspring spermatogenesis might be through epigenetic modifications

Recent trends in fluorescent aptasensors for mycotoxin detection in food: Principles, constituted elements, types, and applications

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