Toxic epidermal necrolysis in HIV-infected patients: are intravenous immunoglobulins really necessary in this subgroup?

Abstract

The spectrum of Stevens–Johnson syndrome/toxic epidermal necrolysis (TEN) is the most severe form of cutaneous adverse reactions to drugs. We report a case of a HIV-positive man with TEN who presented a very good response to a single dose of intravenous immunoglobulins and a short pulse of corticosteroids, together with intensive supportive care. Although the largest study on the management of this type of patients reported to date suggests a scheme of three doses of intravenous immunoglobulins together with glucocorticoids, we implemented a single dose of immunoglobulins due to lack of availability.

An individual patient data meta‐analysis of wound care in patients with toxic epidermal necrolysis

“…Similarly, participants who underwent any debridement were allocated to the ‘debridement’ group. These debrided participants represented centres practising conservative wound care 35‐42 and centres where routine debridement is practised 29,32,43,44,45,46,47,48,49,50,51,52,53,54,55 …”

“…Similarly, participants who underwent any debridement were allocated to the 'debridement' group. These debrided participants represented centres practising conservative wound care [35][36][37][38][39][40][41][42] and centres where routine debridement is practised. 29,32,43,44,45,46,47,48,49,50,51,52,53,54,55 Where the data were not available in the article, the study authors were contacted via email/phone to provide this information.…”