Toxic Impacts of Amorphous Silica Nanoparticles on Liver and Kidney of Male Adult Rats: an In Vivo Study

Azouz, Rehab A.; Korany, Reda M. S.

doi:10.1007/s12011-020-02386-3

Cited by 35 publications

(15 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interleukin-1 released in early stage of infection as pro-inflammatory cytokines that regulates both types of immunity (innate and acquired stage); IL-1β was the most potent and fastest genes in humoral immunity that stimulate the inflammation and trigger the immunity. IL-1β originated from liver and kidneys as well as underlying tissues [ 19–21 ]. In the present study, we evaluated the expression of the two genes, IL-1β and IL-6, in the rats liver tissues under different concentrations of the tested nanomaterials.…”

Section: Discussionmentioning

confidence: 99%

“…At the end of the experimental period, blood samples were obtained from the retro-orbital venous plexus of the control and treated rats, blood was allowed to clot at room temperature before being centrifuged at 3000 rpm for 10 min to separate the serum, serum was stored at −20°C for the biochemical analysis [ 19 ]. Liver of the examined rats were aseptically dissected and stored at −80°C for gene expression.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Insecticidal efficacy of nanomaterials used to control mosquito, Culex quinquefasciatus Say, 1823 with special reference to their hepatotoxicity in rats

et al. 2022

View full text Add to dashboard Cite

This study aimed to develop a novel methodology for controlling the mosquito larvae using different nanoparticles, with special reference to their effect on rats (a non-target mammalian model). The mosquito species of Culexquinquefasciatus was reared in the laboratory. Chitosan; silver nanoparticles and their combination as well as lavender (Lavandula officinalis) nanoemulsion with different concentrations were tested as biological insecticides against the mosquito larvae. Mammalian toxicity of the used nanoparticles were evaluated using twenty seven adult male rats, experimental rats were divided into nine equal groups (n = 3). The nanoparticles were added to the drinking water for 30 days. At the end of the study, blood and tissue samples were collected to assess the levels of the serum ALT and AST, different genes expression as Interleukin 6 (IL-6) and IL-1β activity. Histopathological and immunohistochemical studies using two markers (TNF-α and BAX expression) were also applied. The LC50 and LC90 were recorded for each tested nanoparticles, also the changes of the treated mosquito larvae cuticle were assessed using the Scanning Electron Microscopy (SEM). Conclusion: green nanoemulsion (Lavandula officinalis) was more effective than metal (silver) or even biodegradable (chitosan) nanoparticles in controlling of Culexquiquefasciatus mosquito larvae, and also it proved its safety by evaluation of the mammalian hepatotoxicity of the tested nanoparticles.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Insecticidal efficacy of nanomaterials used to control mosquito, Culex quinquefasciatus Say, 1823 with special reference to their hepatotoxicity in rats

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The quantitative immunoreactivity of Ki-67 and caspase-3 was evaluated in neoplastic cells in each group according to Azouz and Korany [ 75 ]; five kidney sections were examined. Immuno-reactivity was analyzed in 10 microscopical fields per each section under high-power microscopic field (×400).…”

Section: Methodsmentioning

confidence: 99%

Protective and Therapeutic Efficacy of Hesperidin versus Cisplatin against Ehrlich Ascites Carcinoma-Induced Renal Damage in Mice

et al. 2022

Self Cite

View full text Add to dashboard Cite

This study evaluates the antitumor efficacy of hesperidin (Hesp) versus cisplatin (Cis) in Ehrlich ascites carcinoma (EAC)-bearing mice, as well as its protective effect against Cis-triggered nephrotoxicity. Seventy female mice were allocated into control, Hesp, EAC, Hesp-protected, Hesp-treated, Cis-treated, and Cis+Hesp-treated groups. The inoculation of mice with EAC cells significantly reduced the mean survival time, while significantly increased the body weight, abdominal circumference, ascitic fluid volume, viable tumor cell count, and serum carcinoembryonic antigen, urea and creatinine levels, besides various hematological changes. Additionally, kidney tissue of EAC-bearing mice showed a significant increase in the malondialdehyde level, significant decreases in the reduced glutathione content and catalase activity, marked pathological alterations, and a strong Ki-67 expression with a weak caspase-3 expression in neoplastic cells infiltrating the renal capsule. Conversely, the administration of Hesp and/or Cis to the EAC-bearing mice induced, to various degrees, antitumor responses and alleviated the cytotoxic effects of EAC. In addition to the potent antitumor effect of the concomitant administration of Hesp and Cis, Hesp minimized the renal adverse side effects of Cis. In conclusion, Hesp may open new avenues for safe and effective cancer therapy and could be valuable for enhancing the antitumor potency and minimizing the renal adverse side effects of chemotherapeutic drugs.

show abstract

“…Histopathological alterations were scored as, no changes (0), mild (1), moderate (2), and severe (3) changes, while the grading was estimated by percentage as follows: <30% changes were indicated as mild, <30%-50% indicated as moderate changes, and > 50% indicated as severe changes. 34…”

Section: Histopathological Examinationmentioning

confidence: 99%

Nigella sativa oil protects against emamectin benzoate‐Induced neurotoxicity in rats

Madkour

Ahmed

Orabi

et al. 2021

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

This study evaluated the ameliorative impact of Nigella sativa oil (NSO) on emamectin benzoate (EMB) neurotoxicity. Thirty-five male rats were randomly allocated into 5 groups (n = 7). G1 (control): received distilled water; G2: received NSO (3 ml. Kg À1 B.W.) for 6 weeks; G3: received EMB (9 mg kg À1 B.W.) for 6 weeks; G4: was cotreated with NSO and EMB for 6 weeks; G5: was treated with EMB for 4 weeks then, received NSO for 2 weeks. All treatments were given orally every other day.EMB increased serum urea, creatinine levels; brain dopamine, serotonin, malondialdehyde levels; brain expression levels of caspase 3 and TNF-α. While, it decreased serum total protein, albumin, brain GABA, AChE, GSH-Px, CAT, and SOD levels. Histopathological findings revealed hemorrhage, congestion, severe degeneration, and edema of the brain tissues. NSO reversed the EMB-induced biochemical and histopathological alterations. This NSO effect is mostly due to its antioxidant, antiinflammatory, and antiapoptotic activities. These findings suggest NSO as a potential protective and therapeutic agent for EMB-induced neurotoxicity.

show abstract

Toxic Impacts of Amorphous Silica Nanoparticles on Liver and Kidney of Male Adult Rats: an In Vivo Study

Cited by 35 publications

References 50 publications

Insecticidal efficacy of nanomaterials used to control mosquito, Culex quinquefasciatus Say, 1823 with special reference to their hepatotoxicity in rats

Insecticidal efficacy of nanomaterials used to control mosquito, Culex quinquefasciatus Say, 1823 with special reference to their hepatotoxicity in rats

Protective and Therapeutic Efficacy of Hesperidin versus Cisplatin against Ehrlich Ascites Carcinoma-Induced Renal Damage in Mice

Nigella sativa oil protects against emamectin benzoate‐Induced neurotoxicity in rats

Contact Info

Product

Resources

About