Toxic manifestations in the newborn infant following placental transmission of sulfanilamide

BritishHIVAssociation guidelines on the management of opportunistic infection in people living withHIV: Considerations in pregnancy 2024

“…Toxicities that may be observed in the neonate include jaundice, haemolytic anaemia and kernicterus. Severe jaundice in the neonate has been related to maternal sulfonamide ingestion at term by several authors [75][76][77][78][79][80]. Premature infants seem to be especially prone to the development of hyperbilirubinaemia [79].…”

“…Premature infants seem to be especially prone to the development of hyperbilirubinaemia [79]. Haemolytic anaemia has been reported in two neonates and in a fetus following in utero exposure to sulfonamides [75,76,80]; both neonates survived. Because of the potential toxicity to the neonate, these agents should be avoided near term.…”