Toxic mechanism of three azole fungicides and their mixture to green alga Chlorella pyrenoidosa

Nong, Qiong-Yuan; Liu, Yongan; Qin, Li-Tang; Liu, Min; Mo, Ling-Yun; Liang, Yanpeng; Zeng, Honghu

doi:10.1016/j.chemosphere.2020.127793

Cited by 43 publications

(17 citation statements)

References 57 publications

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“…Almeida et al [91] and Silva et al [92] reported growth inhibition of Raphidocelis subcapitata and Microcystis novacekii after exposure to acyclovir, efavirenz, lamivudine, zidovudine and tenofovir (Table 3). The effect of the antifungals propiconazole and tebuconazole on the growth and antioxidant response of the microalga Chlorella pyrenoidosa was evaluated by Nong et al [93], identifying that doses of 100, 200 and 1000 µg L −1 were enough to inhibit growth. These authors also observed a gradual increase of the activity of the enzyme biomarkers SOD and catalase (CAT) with concentrations ranging from 100 to 20,000 µg L −1 .…”

Section: Microalgae and Cyanobacteriamentioning

confidence: 99%

Occurrence and Effects of Antimicrobials Drugs in Aquatic Ecosystems

et al. 2021

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Currently, thanks to the development of sensitive analytical techniques, the presence of different emerging pollutants in aquatic ecosystems has been evidenced; however, most of them have not been submitted to any regulation so far. Among emerging contaminants, antimicrobials have received particular attention in recent decades, mainly due to the concerning development of antibiotic resistance observed in bacteria, but little is known about the toxicological and ecological impact that antimicrobials can have on aquatic ecosystems. Their high consumption in human and veterinary medicine, food-producing animals and aquaculture, as well as persistence and poor absorption have caused antimicrobials to be discharged into receiving waters, with or without prior treatment, where they have been detected at ng-mg L−1 levels with the potential to cause effects on the various organisms living within aquatic systems. This review presents the current knowledge on the occurrence of antimicrobials in aquatic ecosystems, emphasizing their occurrence in different environmental matrixes and the effects on aquatic organisms (cyanobacteria, microalgae, invertebrates and vertebrates).

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Section: Microalgae and Cyanobacteriamentioning

confidence: 99%

Occurrence and Effects of Antimicrobials Drugs in Aquatic Ecosystems

et al. 2021

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“…Their most prominent biological activity is antifungal activity, with proven efficacy in the treatment of fungal pathogens in humans, animals, and plants [114,115]. In fact, there are commercial azole fungicides on the market such as myclobutanil, propiconazole, and tebuconazole [116]. They are widely used in personal care products, UV stabilizers, and in aircraft for their anticorrosion properties.…”

Section: Azolesmentioning

confidence: 99%

Recent Applications of Heteropolyacids and Related Compounds in Heterocycle Synthesis. Contributions between 2010 and 2020

et al. 2021

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Over the past two decades, polyoxometalates (POM) have received considerable attention as solid catalysts, due to their unique physicochemical characteristics, since, first, they have very strong Bronsted acidity, approaching the region of a superacid, and second, they are efficient oxidizers that exhibit rapid redox transformations under fairly mild conditions. Their structural mobility is also highlighted, since they are complex molecules that can be modified by changing their structure or the elements that compose them to model their size, charge density, redox potentials, acidity, and solubility. Finally, they can be used in substoichiometric amounts and reused without an appreciable loss of catalytic activity, all of which postulate them as versatile, economic and ecological catalysts. Therefore, in 2009, we wrote a review article highlighting the great variety of organic reactions, mainly in the area of the synthesis of bioactive heterocycles in which they can be used, and this new review completes that article with the contributions made in the same area for the period 2010 to 2020. The synthesized heterocycles to be covered include pyrimidines, pyridines, pyrroles, indoles, chromenes, xanthenes, pyrans, azlactones, azoles, diazines, azepines, flavones, and formylchromones, among others.

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“…Thus, it is concluded that exposure of PBDEs could cause signi cant changes in the contents of soluble protein in aquatic organisms according to the results obtained in this work and the published literatures, and the decrease in contents of soluble protein in the cells may be due to the following reasons. (1) Various propagating radicals and ROS would be excessively generated in the algal cells under the exposure of PBDEs, which were reported to affect the structures and compositions of protein, and hinder the synthesis of protein (Nong et al, 2021). For example, ROS would cause oxidative modi cations of amino acid side chains, ROS-mediated peptide cleavage, reactions of peptides with lipids and carbohydrate oxidation products, and the formation of carbonyl derivatives of proteins (Valavanidis et al, 2006).…”

Section: Effects Of Bde-15 On Soluble Protein Contentmentioning

confidence: 99%

Growth Inhibition and Oxidative Stress Caused by 4,4'-dibromodiphenyl Ether (BDE-15) on a Marine Diatom Phaeodactylum Tricornutum

Dong

Gao

Qian

et al. 2021

Preprint

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In this work, Phaeodactylum tricornutum was used to investigate the toxicity of 4,4'-dibromodiphenyl ether (BDE-15). Results showed that BDE-15 inhibited the photosynthetic activity and growth of P. tricornutum significantly with 24, 48, 72, and 96 h EC50 values of 1.03, 0.44, 0.41, and 0.42 mg L-1, respectively, indicating that it was a highly toxic substance. Moreover, BDE-15 could cause cell deformation, and a series of physiological, biochemical, and molecular changes in the cells. Under the exposure of BDE-15, contents of chlorophyll a and soluble protein decreased significantly, but reactive oxygen species (ROS) were accumulated in the algal cells, which may cause or intensify the peroxidation of membrane lipids. For alleviating the toxicity of excessive ROS, activities of antioxidant enzymes increased dramatically when this diatom was exposed to BDE-15. Thus, it is concluded that the overproduction of ROS may be regarded as one of the major factors in BDE-15 toxicity.

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Toxic mechanism of three azole fungicides and their mixture to green alga Chlorella pyrenoidosa

Cited by 43 publications

References 57 publications

Occurrence and Effects of Antimicrobials Drugs in Aquatic Ecosystems

Occurrence and Effects of Antimicrobials Drugs in Aquatic Ecosystems

Recent Applications of Heteropolyacids and Related Compounds in Heterocycle Synthesis. Contributions between 2010 and 2020

Growth Inhibition and Oxidative Stress Caused by 4,4'-dibromodiphenyl Ether (BDE-15) on a Marine Diatom Phaeodactylum Tricornutum

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