Toxic Metabolites of Aspergillus Flavus

Hartley, Roy D.; Nesbitt, Brenda F.; O'Kelly, JC

doi:10.1038/1981056a0

Cited by 178 publications

(62 citation statements)

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“…The molecular formula of aflatoxin B1 was established as C 17 H 12 0 6 and of aflatoxin G1 as C 17 H 12 0 7 ; aflatoxins B2 and G2 were found to be the dihydro derivatives of the parent compounds, C 17 H 14 0 6 and C 17 H 14 0 7 (Hartley et al, 1963). Some physical properties of the compounds are summarized in following The spectral characteristics of the aflatoxins have been determined by several investigators and are summarized in Table 2.…”

Section: Physical Propertiesmentioning

confidence: 99%

Aflatoxins and Aflatoxicosis in Human and Animals

Dhanasekaran¹,

Shanmugapriya²,

Thajuddin³

et al. 2011

Aflatoxins - Biochemistry and Molecular Biology

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Section: Physical Propertiesmentioning

confidence: 99%

Aflatoxins and Aflatoxicosis in Human and Animals

Dhanasekaran¹,

Shanmugapriya²,

Thajuddin³

et al. 2011

Aflatoxins - Biochemistry and Molecular Biology

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“…The sudden appearance of turkey-X disease in 1960, which resulted in the death of over 100 000 turkeys in the United Kingdom, led to the discovery of a family of structurally related metabolites called a£atoxins [1,2]. A£atoxins are secondary metabolites produced by the ¢lamentous fungi Aspergillus £avus and Aspergillus parasiticus.…”

Section: Introductionmentioning

confidence: 99%

Genetic organization and function of the aflatoxin B1 biosynthetic genes

Woloshuk

1998

FEMS Microbiology Letters

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Aflatoxins are secondary metabolites produced by Aspergillus flavus and Aspergillus parasiticus. Most of the genes involved in the biosynthesis of aflatoxin are contained within a single cluster in the genome of these filamentous fungi. Studies directed toward understanding the molecular biology of aflatoxin biosynthesis have led to a number of important discoveries. A pair of fatty acid synthase genes were identified that are involved uniquely in aflatoxin biosynthesis. Two genes were also characterized that represent new families of cytochrome P450 monooxygenases. Gene expression is coordinated during aflatoxin production and is under the control of a positive regulatory gene belonging to a family of fungal transcriptional activators associated with various metabolic pathways in fungi. z 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V.

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“…The toxins are usually found as a mixture of AFB 1 , AFB 2 , AFG 1 and AFG 2 (Hartley et al, 1963). Aflatoxin B 1 is the most potent naturally occurring carcinogen (Ayyat et al, 2013;Binder et al, 2007).…”

mentioning

confidence: 99%