Toxic plants act as indiscriminate protectors of insects

Ormosianines A–P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis

“…As a result, 16 previously undescribed QAs, ormosianines A−P (1−16), comprising five distinct types with a varied number of piperidine rings, along with 18 known analogs (17−34), were isolated and identified. Compounds 1,4,6,[11][12][13]16,24, and 27−29 effectively reversed antiacetylcholinesterase effects with IC 50 values ranging from 1.55 to 29.6 μM. The underlying interactions between selected bioactive compounds (1, 12, 13, and 16) and AChE (1DX4) were predicted via molecular docking studies.…”

“…Inhibition of AChE by carbamate or organophosphorus insecticides can be fatal. , However, extensive use of the market-available insecticides to control insect pests has led to the occurrence of resistant enzymes or insect resistance . Bitter seeds of leguminous plants are naturally toxic to insects, partially due to the presence of QA alkaloids . In our search for structurally intriguing natural products with insect resistance and antimicrobial properties, − Ormosia yunnanensis , a species previously not investigated, was selected for a chemical study.…”

“…11 Bitter seeds of leguminous plants are naturally toxic to insects, partially due to the presence of QA alkaloids. 12 In our search for structurally intriguing natural products with insect resistance and antimicrobial properties, 13−16 Ormosia yunnanensis, a species previously not investigated, was selected for a chemical study. As a result, 16 previously undescribed QAs, ormosianines A−P (1−16), comprising five distinct types with a varied number of piperidine rings, along with 18 known analogs (17−34), were isolated and identified.…”