Toxic potential of botulinum toxin type A on senescence in a Drosophila melanogaster model

Fooladvand, Farnoosh; Tahouri, Vida; Baeeri, Maryam; Minaei, Tayebeh; Rahimifard, Mahban; Hodjat, Mahshid; Khorasani, Reza; Haghi‐Aminjan, Hamed; Abdollahi, Mohammad

doi:10.1016/j.toxrep.2021.08.002

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…Interestingly, experimental and preclinical studies suggest that BoNT/A may paradoxically contribute to skin aging. Research by Fooladvand et al [ 112 ] using a Drosophila melanogaster model revealed that BoNT/A can cause DNA damage, activate caspase-3 and -9, and induce cellular senescence, negatively affecting at least three aging hallmarks (i.e., genomic instability, loss of proteostasis, and cellular senescence). In addition, Miao et al [ 113 ] found that BoNT/A treatment in human dermal fibroblasts altered the expression of long non-coding RNAs, with an increase in FOS expression linked to cellular senescence.…”

Section: Reviewmentioning

confidence: 99%

Clinically Actionable Topical Strategies for Addressing the Hallmarks of Skin Aging: A Primer for Aesthetic Medicine Practitioners

Minoretti,

Emanuele

2024

Cureus

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In this narrative review, we sought to provide a comprehensive overview of the mechanisms underlying cutaneous senescence, framed by the twelve traditional hallmarks of aging. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. We also examined how topical interventions targeting these hallmarks can be integrated with conventional aesthetic medicine techniques to enhance skin rejuvenation. The potential of combining targeted topical therapies against the aging hallmarks with minimally invasive procedures represents a significant advancement in aesthetic medicine, offering personalized and effective strategies to combat skin aging. The reviewed evidence paves the way for future advancements and underscores the transformative potential of integrating scientifically validated interventions targeted against aging hallmarks into traditional aesthetic practices.

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Section: Reviewmentioning

confidence: 99%