Toxic pyrrolizidine alkaloids in herbal medicines commonly used in Ghana

Letsyo, Emmanuel; Jerz, Gerold; Winterhalter, Peter; Beuerle, Till

doi:10.1016/j.jep.2017.03.008

Cited by 41 publications

(26 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, concerns regarding T&CM use in combination with CT include potential herb/drug interactions [7], lack of T&CM use disclosure [8,9], directly harmful practices (i.e. non-standardized or unsanitary surgical practices, and/or toxic or contaminated herbal products) [10,11], and delayed or abandoned CT treatment. [12] Concerns regarding CT delay and/or abandonment are particularly important for diseases that benefit from early diagnosis and management with CT, such as cancer or HIV.…”

Section: Introductionmentioning

confidence: 99%

Facilitators and barriers to traditional medicine use among cancer patients in Malawi

Hill

Séguin²,

Phanga³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

BackgroundIncreasing access to conventional cancer treatment (CT) in low-income countries (LICs) is an important public health initiative to address the global burden of cancer. However, LICs have a high prevalence of use of traditional and complementary medicine (T&CM). It is important to consider the factors that influence a patient’s choice to use T&CM, CT, or both for their cancer treatment.MethodsWe conducted focus groups among adult cancer patients in Lilongwe, Malawi to identify facilitators and barriers of T&CM use. Focus groups were recorded, transcribed, translated, and underwent thematic content analysis.ResultsCultural norms, T&CM access, T&CM success, and CT failure were all identified as facilitators to T&CM use. CT success and T&CM failure were identified as barriers. Access and norms appear to determine initial treatment selection, while treatment outcomes dictate continued use of T&CM or CT.ConclusionThis study identified a pragmatic and experience-based treatment selection process that aligns with the social cognitive theory of behavior and assists in comprehending the factors that influence T&CM use among cancer patients in a low resource setting.

show abstract

Section: Introductionmentioning

confidence: 99%

Facilitators and barriers to traditional medicine use among cancer patients in Malawi

Hill

Séguin²,

Phanga³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…The system suitability was ensured by checking whether the RSD values can be collected after five replicates measuring the standard solution. The results were within the acceptance criteria ( 40 ), i.e., RSDs of the area were less than 5% ( Supplemental Data 1 ). Also, this study confirmed the system suitability of the LC-MS/MS by examining these outcomes in retention time, tailing factor, number of theoretical plates, resolution, peak width, and height equivalent to a theoretical plate (the data were not shown).…”

Section: Resultsmentioning

confidence: 65%

LC-ESI-MS/MS Simultaneous Analysis Method Coupled with Cation-Exchange Solid-Phase Extraction for Determination of Pyrrolizidine Alkaloids on Five Kinds of Herbal Medicines

Jeong

Choi

Kim

et al. 2021

Journal of AOAC INTERNATIONAL

View full text Add to dashboard Cite

Background Pyrrolizidine alkaloids (PAs) are naturally occurring plant toxins associated with potential hepatic and carcinogenic diseases in humans and animals. The concern of PAs has been increased as the consumption of herbal medicines is increased. Objective This study aimed to develop and validate a sensitive analytical method to determine 28 PAs in 5 herbal medicines using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Additionally, this study identified and quantified the amount of PA in 10 samples of each herbal medicine. Methods The pretreatment in the proposed LC-MS/MS analysis comprised solvent extraction using 0.05M H2SO4 in 50% methanol and clean-up step by MCX-solid-phase extraction (SPE) cartridge. The PA contents in herbal medicines were measured by using the developed method. Results The proposed method had recoveries ranged from 72.5% ∼ 123.7% for the Atractylodis Rhizoma Alba, 70.6% ∼ 151.7% for Alba Chrysanthmi Flos, 80.6% ∼ 130.9% for Leonuri Herba, 70.3% ∼ 122.9% for Gastrodiae Rhizoma, and 67.1% ∼ 106.9% for Glycyrrhizae Radix. Even though a few samples showed recoveries in unsatisfactory values, the proposed method indicated entirely sufficient recoveries and precisions in most samples. In monitoring results, only Leonuri Herba contained two PAs, which indicated Retrorsine (4/10) of 84.7 ∼ 120.9 μg/kg and Senkirkine (10/10) of 60.9 ∼ 170.7 μg/kg. Conclusions and Highlights As the proposed method is revealed to be a reliable procedure for monitoring 28 PAs in herbal medicines, it seems to contribute to controlling the risks coming from pyrrolizidine alkaloids in certain medicinal plants and dietary supplements.

show abstract

“…Studies have identified herbs and fungi commonly used as traditional remedies which may cause acute or chronic liver injury [14,15]. In sub-Saharan Africa, consumption of traditional herbal treatments, is known to be common practice and in some cases associated with toxicity [16].…”

Section: Introductionmentioning

confidence: 99%

Suspected paracetamol overdose in Monrovia, Liberia: a matched case–control study

Haidar

Vogt²,

Takahashi³

et al. 2020

BMC Pediatr

View full text Add to dashboard Cite

Background: A cluster of cases of unexplained multi-organ failure was reported in children at Bardnesville Junction Hospital (BJH), Monrovia, Liberia. Prior to admission, children's caregivers reported antibiotic, antimalarial, paracetamol, and traditional treatment consumption. Since we could not exclude a toxic aetiology, and paracetamol overdose in particular, we implemented prospective syndromic surveillance to better define the clinical characteristics of these children. To investigate risk factors, we performed a case-control study. Methods: The investigation was conducted in BJH between July 2015 and January 2016. In-hospital syndromic surveillance identified children with at least two of the following symptoms: respiratory distress with normal pulse oximetry while breathing ambient air; altered consciousness; hypoglycaemia; jaundice; and hepatomegaly. After refining the case definition to better reflect potential risk factors for hepatic dysfunction, we selected cases identified from syndromic surveillance for a matched case-control study. Cases were matched with in-hospital and community-based controls by age, sex, month of illness/admission, severity (in-hospital), and proximity of residence (community). Results: Between July and December 2015, 77 case-patients were captured by syndromic surveillance; 68 (88%) were under three years old and 35 (46%) died during hospitalisation. Of these 77, 30 children met our case definition and were matched with 53 hospital and 48 community controls. Paracetamol was the most frequently reported medication taken by the cases and both control groups. The odds of caregivers reporting supratherapeutic paracetamol consumption prior to admission was higher in cases compared to controls (OR 6.6, 95% CI 2.1-21.3). Plasma paracetamol concentration on day of admission was available for 19 cases and exceeded 10 μg/ mL in 10/13 samples collected on day one of admission, and 4/9 (44%) collected on day two.

show abstract

Toxic pyrrolizidine alkaloids in herbal medicines commonly used in Ghana

Cited by 41 publications

References 18 publications

Facilitators and barriers to traditional medicine use among cancer patients in Malawi

Facilitators and barriers to traditional medicine use among cancer patients in Malawi

LC-ESI-MS/MS Simultaneous Analysis Method Coupled with Cation-Exchange Solid-Phase Extraction for Determination of Pyrrolizidine Alkaloids on Five Kinds of Herbal Medicines

Suspected paracetamol overdose in Monrovia, Liberia: a matched case–control study

Contact Info

Product

Resources

About