Toxic Stress: Effects, Prevention and Treatment

Franke, H

doi:10.3390/children1030390

Cited by 175 publications

(164 citation statements)

References 60 publications

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“…[15] Typically, acute stress promotes an adaptive stress response whereby highly integrated physiological systems dynamically adjust to environmental challenges in order to maintain stability, also known as allostasis. Toxic ELS is defined as prolonged, repetitive, or severe adversity in the absence of a nurturing environment, and include ACEs such as neglect, separation from a nurturing parent, prolonged abuse or bullying, or the psychosocial stressors associated with ACEs that may disrupt the physiological stress response.…”

Section: Adverse Childhood Experiences Are a Form Of Toxic Early Lifementioning

confidence: 99%

“…Toxic ELS is defined as prolonged, repetitive, or severe adversity in the absence of a nurturing environment, and include ACEs such as neglect, separation from a nurturing parent, prolonged abuse or bullying, or the psychosocial stressors associated with ACEs that may disrupt the physiological stress response. [15] Typically, acute stress promotes an adaptive stress response whereby highly integrated physiological systems dynamically adjust to environmental challenges in order to maintain stability, also known as allostasis. [16] Toxic stress, on the other hand, increases allostatic load, or the biological result of cumulative stress over time, resulting in physiological dysfunction from this sustained chronic stress response.…”

Section: Adverse Childhood Experiences Are a Form Of Toxic Early Lifementioning

confidence: 99%

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Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress

2018

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This manuscript reviews recent evidence supporting the utility of telomeres and mitochondrial DNA copy number (mtDNAcn) in detecting the biological impacts of adverse childhood experiences (ACEs) and outlines mechanisms that may mediate the connection between early stress and poor physical and mental health. Critical to interrupting the health sequelae of ACEs such as abuse, neglect, and neighborhood disorder, is the discovery of biomarkers of risk and resilience. The molecular markers of chronic stress exposure, telomere length and mtDNAcn, represent critical biological links between ACEs and poor health outcomes. We examine how telomeres and mtDNAcn may exacerbate health disparities and contribute to the intergenerational transmission of trauma. Finally, we explore how these molecular markers of early stress exposure may help define the role of resilience and develop effective interventions to moderate ACE health risk impact.

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Section: Adverse Childhood Experiences Are a Form Of Toxic Early Lifementioning

confidence: 99%

Section: Adverse Childhood Experiences Are a Form Of Toxic Early Lifementioning

confidence: 99%

Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress

2018

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“…Children who experience early life toxic stress are at risk of long-term adverse health effects, which might not be manifest until adulthood. These adverse health effects include maladaptive coping skills, poor stress management, unhealthy lifestyles, mental illness, and physical disease (Franke 2014). VAC has important economic and social consequences for nations.…”

Section: Vac In the Displacement Contextmentioning

confidence: 99%

Violence Against Children

Anker¹,

Weissbacher²,

Millinger³

2019

The SAGE Encyclopedia of Criminal Psychology

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Some rights reserved. The findings, interpretations, and conclusions expressed in this work do not necessarily reflect the views of The World Bank, its Board of Executive Directors, or the governments they represent. The World Bank does not guarantee the accuracy of the data included in this work. Nothing herein shall constitute or be considered to be a limitation upon or waiver of the privileges and immunities of The World Bank, all of which are specifically reserved.

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“…Značajne su preventivne mere kojima se povećava otpornost deteta prema stresu što predstavlja i pomoć negovatelju. Ublažavanje toksičnog odgovora na stres postiže se i fokusiranjem na stresore negovatelja i poboljšavanjem njegove sposobnosti da obezbedi stabilan, siguran i negujući odnos (19).…”

Section: Skrining Prevencija I Lečenje Toksičnog Stresaunclassified

Toksični Stres U Detinjstvu I Rizik Za Dugoročne Zdravstvene Posledice

Bogdanović¹,

Lozanović²

2019

SCEPED

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Nepovoljna iskustva u detinjstvu (NID), uključujući zlostavljanje, zanemarivanje,disfunkcionalnu porodicu i druge stresne ili traumatične nedaće u detinjstvu, povezanesu sa dugoročnim negativnim zdravstvenim posledicama. Kao doprinoseći činilacu nastanku ovih posledica uključen je toksični stresni odgovor. Fiziološki odgovor nadelovanje stresora određen je višestrukim faktorima, uključujući trajanje i jačinu izloženosti,zaštitne faktore ili ranjivosti i razvojne činioce. Odgovor na delovanje stresoramože biti adaptacioni (fiziološki) ili maladaptacioni (patološki). U odgovoru na delovanjestresora nervni, endokrini i imunski sistem integrišu se u jedinstven neuro-endokrino-imunski sistem. Ako je izloženost stresoru vremenski ograničena i ukoliko osobaposeduje odgovarajuće mehanizme za suprotstavljanje, ovi sistemi podležu vremenskiograničenoj adaptaciji da bi se organizam vratio u stanje homeostaze. Međutim, dugotrajnaili jaka izloženost delovanju stresora može da prouzrokuje disregulaciju neuro-endokrino-imunskog sistema, oštećujući inhibiciju fidbekom i regulacione mehanizmei stvarajući maladaptacioni, toksični, odgovor na stres. Toksični stres može daprouzrokuje bilo suvišak bilo nedostatak hormona ili neurotransmitera indukovanihstresom, što opet, kada se doživi u toku senzitivnog perioda razvoja u detinjstvu, možeda bude ugrađeno u biološke sisteme u razvoju. Poremećena dostupnost hormona i neurotransmiteraizaziva trajne promene koje pogađaju brojne organske sisteme i funkcije,uključujući arhitekturu mozga, regulaciju endokrinog sistema i imunski odgovor.Promene u više organskih sistema, u sprezi sa genetičkom osetljivošću i epigenetičkomregulacijom, stavljaju osobu u rizik za negativne posledice po fizičko, mentalno i bihevioralnozdravlje u odraslom dobu.

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Toxic Stress: Effects, Prevention and Treatment

Cited by 175 publications

References 60 publications

Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress

Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress

Violence Against Children

Toksični Stres U Detinjstvu I Rizik Za Dugoročne Zdravstvene Posledice

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