Toxicarioside B and toxicarioside C. New cardenolides isolated from Antiaris toxicaria latex-derived dart poison

Carter, Christine A.; Gray, Elizabeth A.; Schneider, Tanya L.; Lovett, Charles M.; Scott, Lincoln; Messer, Adam C.; Richardson, David

doi:10.1016/s0040-4020(97)10174-0

Cited by 25 publications

(20 citation statements)

References 31 publications

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“…Previous investigations concentrated on the latex of A. toxicaria and led to the isolation of cardiac glycosides. [13][14][15][16] In addition to the effect of the cardenolides on the activity of the ubiquitous cell surface enzyme Na ϩ /K ϩ -ATPase, recent studies have demonstrated that cardiac glycosides could inhibit the growth of cancer cells 17,18) and induce their apoptosis via activation of caspase-3, induction of cytochrome C release from mitochondria, and generation of reactive oxygen species. 19) In our present work searching for components with anticancer activity, 11 cardenolides ( Fig.…”

Section: )mentioning

confidence: 99%

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Cardenolides from Antiaris toxicaria as Potent Selective Nur77 Modulators

Jiang

Dai²,

Gao³

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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Toxicarioside D (1), a new cardenolide, along with 10 other known ones, was isolated from the stem of Antiaris toxicaria LESCH. by bioassay-guided fractionation. Their structures were determined on the basis of spectroscopic analysis. All the reported compounds effectively inhibited the growth of various cancer cell lines at nanomolar concentrations. Inhibition of cancer cell growth was accompanied with induction of the expression of Nur77, a potent apoptotic member of the steroid/thyroid hormone receptor superfamily.

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Section: )mentioning

confidence: 99%

“…According to the vicinal coupling constants for the sugar proton signals and the 13 C-NMR shifts, the sugar moiety was determined as 6-deoxy-2-O-methyl-glucopyranose, which agreed with the literature report. 16) Thus compound 1 was elucidated as stro-…”

Section: Cardenolides From Antiaris Toxicaria As Potent Selective Nurmentioning

confidence: 99%

Cardenolides from Antiaris toxicaria as Potent Selective Nur77 Modulators

Jiang

Dai²,

Gao³

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…A Chinese legend says that after being hit with this poison: "Seven up, eight down and nine no life", that means that the victim takes seven steps uphill, eight steps downhill and a ninth final, fatal step. Indeed Antiaris latex is very toxic, containing a cardiac glycosides (another important class of plant toxins) named antiarine (Brandt et al, 1966;Carter et al, 1997, Dolder et al 1955Juslèn et al, 1963Shresta et al, 1992).…”

Section: The Ethnographic Documentationmentioning

confidence: 99%

Poison, plants and Palaeolithic hunters. An analytical method to investigate the presence of plant poison on archaeological artefacts

Borgia¹,

Carlin

Crezzini³

2017

Quaternary International

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In this paper we present the development of a method for the detection of toxic substances on ancient arrow points. The aim is to go back in time until the Palaeolithic period in order to determine if poisonous substances were used to enhance the hunting weapons.The ethnographic documentation demonstrates that hunters of every latitude poisoned their weapons with toxic substances derived from plants and occasionally from animals. This highlights that often the weapons would be rather ineffective if the tips were not poisoned. The fact that toxic substances were available and the benefits arising from their application on throwing weapons, suggests that this practice could be widespread also among prehistoric hunters.The project reviewed the research of the toxic molecules starting from current information on modern plants and working backwards through the ages with the study of ethnographic and historical weapons. This knowledge was then applied to the archaeological material collected from International museum collections.Results have shown that using this method it is possible to detect traces of toxic molecules with mass spectrometry (MS) and hyphenated chromatographic techniques even on samples older than one hundred years, which we consider a positive incentive to continue studying plant poisons on ancient hunting tools.

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“…(1) Krief (2003), (2) Carter et al (1997), (3) Bouquet (1969), (4) Akah et al (1998), (5) Taniguchi et al (1978), (6) Kloos and McCullough (1987), (7) Katende et al (1995), (8) Krief et al (2004).…”

Section: As Shown Inmentioning

confidence: 99%

Ethnomedicinal and bioactive properties of plants ingested by wild chimpanzees in Uganda

Krief

Hladik

Haxaire

2005

Journal of Ethnopharmacology

102

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Wild chimpanzees eat several plant species claimed by traditional healers to cure diseases. However, the behaviour leading apes to ingest these peculiar species is not clearly understood. Some of the items consumed by chimpanzees have low nutritional value, and there is a growing body of evidence suggesting that health might be improved or regulated by such ingestion. Observations concerning the diet and the health condition of wild chimpanzees (Pan troglodytes schweinfurthii) in the Kibale National Park (Uganda) are discussed in relation to the ethnomedicinal utilization of plant species reviewed in literature. Among the 163 plant parts known to be eaten by these chimpanzees, at least 35 (21.4%) are used in traditional medicine as treatments for intestinal parasites, skin infections, reproduction and respiratory diseases. Relationships with pharmacological properties are presented, taking into account the difficulties of interpreting ethnomedicinal data. In conclusion, a greater knowledge of ape's behaviour and health may provide a new complementary method to select plants for biomedical research.

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Toxicarioside B and toxicarioside C. New cardenolides isolated from Antiaris toxicaria latex-derived dart poison

Cited by 25 publications

References 31 publications

Cardenolides from Antiaris toxicaria as Potent Selective Nur77 Modulators

Cardenolides from Antiaris toxicaria as Potent Selective Nur77 Modulators

Poison, plants and Palaeolithic hunters. An analytical method to investigate the presence of plant poison on archaeological artefacts

Ethnomedicinal and bioactive properties of plants ingested by wild chimpanzees in Uganda

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