Toxicidad oral a 60 días del aceite de sacha inchi (Plukenetia volubilis L.) y linaza (Linum usitatissimum L.) y determinación de la dosis letal 50 en roedores

Gorriti, Arilmí; Arroyo, Jorge; Quispe, Fredy Lipa; Cisneros, Braulio; Condorhuamán, Martín; Almora, Yuan; Chumpitaz, Víctor

doi:10.1590/s1726-46342010000300007

Cited by 38 publications

(22 citation statements)

References 15 publications

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“…No mortality was observed till 14 days after drug administration. As all the tested animals survived, the oral LD 50 of LUFO in rats was found to be >5 mL/kg body weight as reported earlier by Gorriti et al ().…”

Section: Resultsmentioning

confidence: 99%

Linseed Oil: An Investigation of its Antiarthritic Activity in Experimental Models

Singh

Nair

Gupta

2011

Phytotherapy Research

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Food sources rich in omega-3 fatty acids have been valued for their beneficial effect in the management of inflammatory disorders. The present study evaluates the antiarthritic and immunomodulatory activity of Linum usitatissimum fixed oil (LUFO) in experimental models. The LUFO produced a dose-dependent reduction in joint swelling and circulating TNF-α levels in both preventive and curative protocols of arthritis induced by complete Freund's adjuvant (CFA). Expression of TNF-R1 and Interleukin (IL) 6 proteins in the arthritic paw was also significantly reduced in the LUFO-treated animals. In the cotton pellet induced granuloma model, LUFO treatment significantly reduced the dry granuloma weight as compared with the control group. Results of our present study thus demonstrate the antiarthritic and disease modifying activity of LUFO. We believe that dietary incorporation of LUFO may be beneficial in the prevention and management of rheumatoid arthritis and other chronic inflammatory disorders.

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Section: Resultsmentioning

confidence: 99%

Linseed Oil: An Investigation of its Antiarthritic Activity in Experimental Models

Singh

Nair

Gupta

2011

Phytotherapy Research

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“…Está claro que el metabolismo de los lípidos en los animales difiere un poco al de los humanos, por eso los estudios farmacológicos pre-clínicos en animales son sólo una referencia del comportamiento de una variable expuesta a una intervención. En el estudio de Gorriti et al (2010) se demostró que un grupo de ratas sanas Holtzman que recibió 0,5 ml/kg/día de aceite de sacha inchi presentó los menores valores promedio de colesterol total comparado con el grupo placebo a los 60 días del estudio, aunque no hubo diferencia estadísticamente significativa. Al analizar la dosis de 200 µl/dia (0,2 ml) de aceite de sacha inchi se puede deducir que al grupo de ratas Holtzman de 251 g se le administró aceite de sacha inchi a razón de 0,8 ml/Kg/dia; en nuestro trabajo el peso promedio de los pacientes del grupo que recibió el aceite fue 62,33 kg, y según lo indicado cada paciente debio de ingerir 50 ml/dia de este aceite, sin embargo la dosis de 20 ml/día equivalió a ingerir 0,3 g/kg/día, la cual nos bastó para demostrar el efecto hipolipemiante del aceite de sacha inchi a una dosis inferior a las dosis estudiadas en las investigaciones toxicológicas referidas anteriormente, entonces podemos decir que la dosis ensayada es segura y tolerable en seres humanos, aunque es necesario más estudios para corroborar estos hallazgos.…”

Section: Resultados Y Discusiónunclassified

Effect the oil of sacha inchi in patients with hypercholesterolemia of Hospital I Naylamp - Essalud

Ruiz¹

2018

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Autor correspondiente: farmatoxico@hotmail.com (J. Ruiz). Fecha de recepción: 17 09 2018. Fecha de aceptación: 04 12 2018. RESUMENEl trabajo está basado en una especie peruana llamada "sacha inchi" (Plukenetia volubilis L.), que brinda un aceite con alto contenido de omega -3 ( -linolénico) y especialmente provee una proporción adecuada de ácidos grasos linoleico /  -linolénico. Objetivos: Establecer el efecto del aceite de Plukenetia volubilis L. (sacha inchi) en pacientes con hipercolesterolemia del hospital I Naylamp -Essalud de Chiclayo. Metodología: Estudio experimental con diseño en paralelo aleatorizado comparativo donde participaron 50 pacientes con Hipercolesterolemia, de los cuales 25 fueron grupo experimental y 25 grupo control, grupos casi homogéneos, con similares características clínicas, características basales y uso de medicamentos, teniendo en cuenta que ningún paciente presentó historia de enfermedad cardiaca coronaria y además firmaron el consentimiento informado para ser considerados en el estudio. La recolección de datos se registró en formatos elaborados por el investigador, la toma de muestra se realizó y procesó en el laboratorio del hospital Naylamp. Se analizó los resultados mediante la prueba t de Student para muestras independientes con un nivel de confianza de p< 0,05. Se consideraron criterios éticos y de rigor. Resultados: Después de 12 semanas de tratamiento con ingesta de 20ml/dia de aceite de Sacha Inchi y al comparar los valores del grupo experimental que consumió Aceite Saccha Inchi y el grupo control que solo siguió las recomendaciones de dieta y ejercicio según ATP III se observó que los niveles de colesterol total en el grupo experimental disminuyó por debajo de los valores límites deseables. Conclusiones: La ingesta diaria de 20ml/dia de aceite de Plukenetia volubilis L. (sacha inchi) disminuyó los niveles de colesterol total en pacientes con hipercolesterolemia mejorando su calidad de vida. ABSTRACTThe work was based on Peruvian species called "sacha inchi "(Plukenetia volubilis L.), which provides an oil with high contentof omega -3 ( -linolenic) and especially provides a proportion suitable for linoleic and  -linoleic fatty acids. Objectives: To analyze and discuss the effect of Plukenetia volubilis L. (sacha inchi) oil in patients with hypercholesterolemia at the I Naylamp -Essalud hospital in Chiclayo. Methodology: Experimental study with parallel randomized comparative design involving 50 patients with hypercholesterolemia, of which 25 were experimental group and 25 control group, almost homogeneous groups, with similar clinical characteristics, baseline characteristics and use of medications, taking into account that enought Patient presented a history of coronary heart disease. Ethical and rigor criteria were considered. Results: After 12 weeks of treatment with intake of 20ml / day of Sacha Inchi oil, we can infer that the levels of total cholesterol decreased below the desirable limit values. Conclusions: When compared with the experimental group that consumed...

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“…Animals were grouped and received oral treatments for 3, 7, or 21 days in the approximate volume of 400 ml/animal, through the gavage procedure, using a rounded and curved tip needle, rat-specific, which is inserted into the animal's mouth and carefully pushed through the esophagus to the stomach to ensure that the animal receives the full dose administered. 13 The animals received hydroalcoholic solution (methanol and water, 1:1), Dipteryx odorata (160 mg/kg), 10 P. angulata (160 mg/kg), 14 C. esculenta (80 mg/kg), 15 C. esculenta flavonoid glycoside-rich extract (80 mg/kg), estrogen (50 mg/kg estradiol benzoate), and raloxifen (0.75 mg/kg).…”

Section: Oral Administration Of Solutionsmentioning

confidence: 99%

Effects of estrogen-like plant compounds on the vaginal epithelium pituitary, adrenal glands, and uterus of rats

Rodrigues

Moreira

Rossete

et al. 2018

Exp Biol Med (Maywood)

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Plant species with recognized estrogenic activity and widely used by Brazil’s female population to prevent the unpleasant symptoms of menopause were investigated in this work to demonstrate if constituents of taro-inhame ( Colocasia esculenta), cumaru ( Dipteryx odorata), and camapu ( Physalis angulata) have the ability to mimic or interfere with the action of estrogens. Moreover, their potential use as natural sources of estrogen-like substances for hormone replacement therapy was evaluated. (a) In vivo pharmacological assays were conducted to determine the estrogenic effects of D. odorata isoflavone-rich extract, P. angulata physalin-rich extract, and C. esculenta flavonoid glycoside-rich fraction (FG) on endocrine glands and reproductive organs of female rats at three different stages of the life cycle. The protocols consisted of uterotrophic assays and cytological evaluation of vaginal smears to detect mucosa cell alterations correlated with changes in hormone levels in each phase of the estrous cycle of female rats. The results indicated that C. esculenta FG exhibited estrogenic activity in prepubescent, pubescent, and adult ovariectomized female rats, while D. odorata isoflavones only promoted a weight increase in the pituitary gland of prepubescent rats after prolonged treatment and P. angulata physalins induced a weight increment in the adrenal glands of ovariectomized rats. Additionally, C. esculenta exerted a significant effect on the opening of the vaginal canal in prepubescent rats and on vaginal epithelium. Prolonged treatment of ovariectomized rats with FG altered the proportion of different types of vaginal epithelial cells in these animals, suggesting an interference of FG with estrogen levels. Colocasia esculenta FG induced hypertrophy of the uterus and pituitary in ovariectomized rats similar to estradiol. To elucidate the mechanism of action of FG, its effects were compared to those of estradiol and of the selective estrogen receptor modulator raloxifene. The results suggest that the efficacy of C. esculenta FG is mediated by binding to selective estrogen receptors present in each organ and that raloxifene inhibits the mechanism of action of FG in the same way as it inhibits the effects of estradiol. The overall findings indicate that C. esculenta FG mimics the action of estrogens, with reduced harmful effects on specific tissues. Impact statement The results of this work provide preliminary evidence that ovariectomized rats display the vaginal smear cells typical of the estrous phase of mature rats after long-term ingestion of Colocasia esculenta flavonoid glycosides. Moreover, the treatment caused beneficial effects on endocrine and reproductive organs compared to estradiol. The animals did not exhibit significant body weight alterations among the groups, demonstrating the maintenance of standard metabolism and energy balance. The overall findings obtained with the rat model of menopause highlight the importance of dietary consumption of C. esculenta constituents as potential selective estrogen receptor modulators and suggest that they may prevent some of the metabolic disorders related to estrogen deficiency.

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Toxicidad oral a 60 días del aceite de sacha inchi (Plukenetia volubilis L.) y linaza (Linum usitatissimum L.) y determinación de la dosis letal 50 en roedores

Cited by 38 publications

References 15 publications

Linseed Oil: An Investigation of its Antiarthritic Activity in Experimental Models

Linseed Oil: An Investigation of its Antiarthritic Activity in Experimental Models

Effect the oil of sacha inchi in patients with hypercholesterolemia of Hospital I Naylamp - Essalud

Effects of estrogen-like plant compounds on the vaginal epithelium pituitary, adrenal glands, and uterus of rats

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