Toxicidad retiniana de doxicilina intravítrea: Estudio piloto

Aydın, Erdinç; Kazi, Abdul Ahad; Peyman, Gholam A.; Esfahani, Mohammad Riazi; Muñoz-Morales, A.; Kivilcim, Muhamet; Caro-Magdaleno, Manuel

doi:10.4321/s0365-66912007000400007

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…87 Doxycycline may also have a hypotensive effect given that some eyes have experienced a decrease in the intraocular pressure up to 12 mmHg (Table 1). 87…”

Section: Resultsmentioning

confidence: 99%

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Alternative Intravitreal Antibiotics

Vélez-Montoya¹,

Monroy-Esquivel²,

Ortiz-Guevara³

et al. 2023

Retina

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Purpose: To organize, categorize, and create a quick reference guide for the use of intravitreal antibiotic alternatives to the standard combination of vancomycin and ceftazidime for the treatment of endophthalmitis.Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. The authors searched for all available information regarding intravitreal antibiotics in the last 21 years. Manuscripts were selected according to relevance, level of information, and the available data regarding intravitreal dose, potential adverse effects, bacterial coverage, and relevant pharmacokinetic information.Results: The authors included 164 of 1810 manuscripts. The antibiotics were classified according to their class into fluoroquinolones, cephalosporins, glycopeptide and lipopeptide, penicillins and beta-lactams, tetracyclines, and miscellaneous. The authors also included information regarding intravitreal adjuvants for the treatment of endophthalmitis and one ocular antiseptic. Conclusion:The treatment of infectious endophthalmitis is a therapeutic challenge. The current review summarizes the properties of possible intravitreal antibiotic alternatives that should be considered in cases of suboptimal response to initial treatment.

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“…87 Doxycycline may also have a hypotensive effect given that some eyes have experienced a decrease in the intraocular pressure up to 12 mmHg (Table 1). 87…”

Section: Resultsmentioning

confidence: 99%

“…However, a dose of 250 mg/ 0.1 mL or greater showed a 30% decrease in the electroretinogram waves 2 weeks after the injection. 87 Doxycycline may also have a hypotensive effect given that some eyes have experienced a decrease in the intraocular pressure up to 12 mmHg (Table 1). 87…”

Section: Aminoglycosidesmentioning

confidence: 99%

Alternative Intravitreal Antibiotics

Vélez-Montoya¹,

Monroy-Esquivel²,

Ortiz-Guevara³

et al. 2023

Retina

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Pharmacokinetics of intravitreal antibiotics in endophthalmitis

Radhika

Mithal

Bawdekar

et al. 2014

J Ophthal Inflamm Infect

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Intravitreal antibiotics are the mainstay of treatment in the management of infectious endophthalmitis. Basic knowledge of the commonly used intravitreal antibiotics, which includes their pharmacokinetics, half-life, duration of action and clearance, is essential for elimination of intraocular infection without any iatrogenic adverse effect to the ocular tissue. Various drugs have been studied over the past century to achieve this goal. We performed a comprehensive review of the antibiotics which have been used for intravitreal route and the pharmacokinetic factors influencing the drug delivery and safety profile of these antibiotics. Using online resources like PubMed and Google Scholar, articles were reviewed. The articles were confined to the English language only. We present a broad overview of pharmacokinetic concepts fundamental for use of intravitreal antibiotics in endophthalmitis along with a tabulated compendium of the intravitreal antibiotics using available literature. Recent advances for increasing bioavailability of antibiotics to the posterior segment with the development of controlled drug delivery devices are also described.

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