Toxicidad y causas de cambio del régimen antirretroviral en pacientes inmigrantes con infección por el VIH

Vera-Méndez, Francisco Jesús; Trujillo-Santos, Antonio Javier; Cano-Sánchez, A.; Delgado-Romero, B.

doi:10.1016/j.rce.2010.06.008

Cited by 2 publications

(1 citation statement)

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“…Hepatomegaly is often associated with hepatobiliary diseases. Splenomegaly, in turn, is associated with numerous chronic diseases of the liver[33,34,35]. In our study, both the HSI and SSI were significantly increased in the BDL group compared with both control groups, and both indices decreased to near control levels when administered Mel in the BDL + Mel group.…”

Section: Discussionsupporting

confidence: 53%

Antioxidant and anti-inflammatory action of melatonin in an experimental model of secondary biliary cirrhosis induced by bile duct ligation

Colares¹,

Schemitt²,

Hartmann³

et al. 2016

WJG

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AIMTo evaluate the effects of melatonin (Mel) on oxidative stress in an experimental model of bile duct ligation (BDL).METHODSMale Wistar rats (n = 32, weight ± 300 g) were allocated across four groups: CO (sham BDL), BDL (BDL surgery), CO + Mel (sham BDL and Mel administration) and BDL + Mel (BDL surgery and Mel administration). Mel was administered intraperitoneally for 2 wk, starting on postoperative day 15, at a dose of 20 mg/kg.RESULTSMel was effective at the different standards, reestablishing normal liver enzyme levels, reducing the hepatosomatic and splenosomatic indices, restoring lipoperoxidation and antioxidant enzyme concentrations, reducing fibrosis and inflammation, and thereby reducing liver tissue injury in the treated animals.CONCLUSIONThe results of this study suggest a protective effect of Mel when administered to rats with secondary biliary cirrhosis induced by BDL.

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Section: Discussionsupporting

confidence: 53%