Toxicities of Drugs Used in the Management of Fever

Plaisance, Karen I.

doi:10.1086/317518

Cited by 36 publications

(19 citation statements)

References 31 publications

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“…[2,[8][9][10][11][12][13][14] (Evidence A) • The practices of combining or alternating paracetamol and ibuprofen have limited value and are not recommended. [15,16] (Evidence B) • Mefenamic acid is registered for use from 6 months of age and may be an alternative non-steroidal anti-inflammatory (NSAID) to ibuprofen in children with fever.…”

Section: Antipyretic Medicationmentioning

confidence: 99%

Management of acute fever in children: Guideline for community healthcare providers and pharmacists

et al. 2013

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Fever is a normal physiological response to illness that facilitates and accelerates recovery. Although it is often associated with a self-limiting viral infection in children, it may also be a presenting symptom of more serious conditions requiring urgent medical care. Therefore, it is essential to distinguish between a child with fever who is at high risk of serious illness and who requires specific treatment, hospitalisation or specialist care, and those at low risk who can be managed conservatively at home. This guideline aims to assist pharmacists, primary healthcare workers and general practitioners in risk-stratifying children who present with fever, deciding on when to refer, the appropriate use of antipyretic medication and how to advise parents and caregivers.

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Section: Antipyretic Medicationmentioning

confidence: 99%

Management of acute fever in children: Guideline for community healthcare providers and pharmacists

et al. 2013

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“…Ibuprofen and paracetamol are safe and effective for short-term use in children. 2,[5][6][7][8][9][10][11] The practice of combining or alternating paracetamol and ibuprofen has limited value and is not recommended. [12][13][14] Mefenamic acid is registered for use from six months of age, and may be an alternative nonsteroidal anti-inflammatory drug (NSAID) to ibuprofen in children with fever.…”

Section: Antipyretic Medicationmentioning

confidence: 99%

Fever in children: how to minimise risk and provide appropriate therapy

Green

Pentz

2014

South African Family Practice

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The management of fever in children is a subject that garners many different opinions and interventions. Various approaches seem to be acceptable, from the physician who never uses antipyretic medication, to the use of multiple combination therapies. Following the recent publication of guidelines for the management of acute fever in children, there is now a standard against which fever in children should be managed. These guidelines aim to standardise the process of examining pyrexial children, elicit a reasonable history and then investigate the likely illnesses, so as to justify appropriate therapy.

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“…Surface cooling blankets are poorly tolerated, do not work efficiently, and can cause thermal injuries to the skin. In addition, surface cooling methods in febrile patients frequently elicit shivering, which increases the patients' temperature, discomfort, and metabolic demand [118]. As an alternative, air-cooled blankets were tested in 220 neurologic critical care patients whose temperature reached or exceeded 38.3 C [119].…”

Section: Treatment Of Fevermentioning

confidence: 99%