Toxicities of PCBs to Fish and Environmental Residues

Stalling, David L.; Mayer, Foster L.

doi:10.2307/3428169

Cited by 20 publications

(14 citation statements)

References 7 publications

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“…The PCB residues in fish closely resemble the PCB to which the fish was exposed. There was little change in the relative concentrations of the various homologs (85). Consistent with this observation it has been found that mono-, di-, and tetrachlorobiphenyls are not metabolized by trout (82).…”

Section: Metabolism Of Pcb and Pbb Mixturesupporting

confidence: 73%

Metabolism and biochemical toxicity of PCBs and PBBs

Matthews¹,

Fries²,

Gardner³

et al. 1978

Environ Health Perspect

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Section: Metabolism Of Pcb and Pbb Mixturesupporting

confidence: 73%

Metabolism and biochemical toxicity of PCBs and PBBs

Matthews¹,

Fries²,

Gardner³

et al. 1978

Environ Health Perspect

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“…The dietary levels of 10 and 100 ppm resulted in mean whole fish concentrations of 2.3 and 81.1 ppm respectively (36) and concentrations above these levels have been reported in free-living fish (1, 22, 37,42,48,51).…”

Section: Pcb Groupsmentioning

confidence: 92%

The ultrastructure of the liver of the rainbow trout: normal structure and modifications after chronic administration of a polychlorinated biphenyl Aroclor 1254

Hacking¹,

Budd²,

Hodson³

1978

Can. J. Zool.

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HACKING, M. A., J. BUDD, and K. HODSON. 1977. The ultrastructure of the liver of the rainbow !rout: normal structure and modifications after chronic administration of a polychlorinated biphenyl Aroclor 1254. Can. J. Zool. 56: 477-491.Rainbow trout (Salmo gairdneri) were fed dietary levels of 0-, 1-, lo-, and 100-ppm Aroclor 1254 for 229 to 330 days. The ultrastructural features of control livers were similar to those of other animals, but rainbow trout liver differed from mammalian liver in an apparent absence of Kupffer cells. Also small dense duct-type cells were present that formed a transition zone, combining with hepatocytes to form canaliculi; alone they formed preductules and in combination with cells of lower density they formed ductules. Microtubules were found in the vicinity of canaliculi and less frequently adjacent to the plasma membrane of other cell surfaces. They were not seen at the sinusoidal border as they are in mammalian liver. Peroxisomes lacked nucleoids. There were no ultrastructural liver changes in the 1-ppm group. The most frequently encountered alterations in both the 10-and 100-ppm groups were those involving the nucleus. These included irregular and bizarre nuclear outlines, separation of nucleolar components, and large nuclear pseudoinclusions. Other frequently encountered changes were slight increases in smooth endoplasmic reticulum, altered rough endoplasmic reticulum, increased lysosomes, reduced and altered glycogen, increased lipid, and hypoxic vacuoles. Seen also were concentric membrane arrays, myelin figures in intercellular spaces and Golgi cisternae, and bundles of fine tubules throughout the cytoplasm. HACKING, M. A., J. BUDD et K. HODSON. 1977. The ultrastructure of the liver of the rainbow trout: normal structure and modifications after chronic administration of a polychlorinated biphenyl Aroclor 1254. Can. J . Zool. 56: 477-491.Des truites arc-en-ciel (Salmo gairdneri) ont ete nourriesdedietescontenant 0, 1, lOet 100 ppm d'Aroclor 1254 durant 229-330 jours. L'ultrastructure des foies-temoins ressemble a celle d'autres animaux, mais le foie de la truite arc-en-ciel difFere du foie des mammiferes par I'absence apparente des cellules de Kupffer. On constate egalement la presence de petites cellules opaques semblables aux cellules des canaux, cellules qui forment une zone de transition en se combinant aux hepatocytes pour constituer des canalicules; seules, ces cellules forment des precanalicules, combineesad'autres, ellesformentdescanalicules. On trouve des microtubulesdans levoisinage des canalicules et, plus rarement, on les trouve adjacentes a la membrane plasmatique d'autres cellules. On ne les voit pas 2 la bordure des sinuso~des, comme chez les mammiferes. Les

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“…PCBs are separated from certain pesticides in the usual cleanup procedures, e.g., adsorption chromatography on Florisil or alumina or by gel permeation chromatography (48,66,67). When DDT, TDE, DDE, chlordane, or toxaphene are present, ancillary procedures designed to separate these chemicals from PCBs must be used.…”

Section: Determination Of Pcb Residuesmentioning

confidence: 99%