Toxicity after reirradiation of pulmonary tumours with stereotactic body radiotherapy

Rebuttal from Dr. Nguyen and Dr. Palma

“…Toxicities were dependent on tumor location: treatment of central tumors was associated with grade 4 (n=2) and grade 5 (n=3) toxicities. Peripheral tumors, however, had no grade 4-5 toxicities (6). These findings support the use of cautious salvage SBRT in carefully selected patients.…”

Twenty-six years follow up of bronchio-alveolar lung cancer using local surgical and repeated radiation techniques

“…Serious side-effects with massive lung bleeding after re-irradiation of central lung tumors was described, mainly in large target volumes and central tumor locations, by Peulen, et al [4]. In our case, temporary hemoptysis occurred in April 2011 which was most probably induced by local tumor recurrence (malignant cells found after cytologic evaluation) and not regarded as late radiation toxicity.…”

“…Recently, also repeated radiation treatments are considered if there is not too much of dose overlap and/or a small clinical target volume involved. Repeated radiation treatments in the same lung localization are not yet well-defined and biological tissue effects, such as late toxicity, are described [3][4]. We here present a rare case of a lung cancer patient who was treated over twenty-six years with surgery and multiple radiation treatments, mainly in the region of the right middle lobe.…”

Clinical Evaluation Stereotactic Radiation Therapy for Recurrent or Second Primary Mediastinal Lymph Node Metastases Originating From Non-Small Cell Lung Cancer

“…CyberKnife). SRT appears to be an acceptable treatment option for recurrent tumors, and several series report high rates of local control and low incidence of complication in SRT for re-RT of NSCLC [14][15][16][17][18]. We hypothesized that SRT (both FSRT and SBRT) was a safe and efficacious treatment modality for R/SP-MLNMs from NSCLC.…”