Toxicity and anaerobic biodegradability of pyridine and its derivatives under sulfidogenic conditions

Liu, Shiu‐Mei; Wu, Chin-Hung; Huang, Hui-Jung

doi:10.1016/s0045-6535(97)10203-x

Cited by 36 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, L-proline is a nutritional substance, a GRAS compound, and a pharmacologically safe co-former (Wu et al, 2011); therefore, it is a suitable component of the cocrystal. Aakeröy et al (2011) recently described the use of pyridine or pyrimidine derivatives as co-formers in preparing diclofenac cocrystals; however, pyridine and pyrimidine derivatives are toxic (Liu et al, 1998;Sajewicz, 2007) to almost every vital organ in humans. Therefore, it is worth developing DFA-PRO cocrystals, which are a safer alternative and have enhanced bioavailability and pharmacological properties.…”

Section: Powder Solubility In Watermentioning

confidence: 99%

Zwitterionic cocrystal of diclofenac and l-proline: Structure determination, solubility, kinetics of cocrystallization, and stability study

Nugrahani

Utami

Ibrahim

et al. 2018

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

In recent decades, the design of cocrystals has developed significantly due to the unique characteristics and advantages of cocrystals, which help to improve the physicochemical properties of drugs, especially solubility. Zwitterions are attractive and interesting co-formers. However, the physicochemical properties of cocrystals with zwitterionic co-formers, i.e. zwitterionic cocrystals, have not been adequately evaluated. In this study, solid-state characterization of a newly developed zwitterionic cocrystal of diclofenac (DFA), a non-steroidal antiinflammatory drug, and the amino acid L-proline (PRO) was performed using Fourier-transform infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffraction (PXRD) analyses. In addition, the crystal structure of the cocrystal (DFA-PRO) was determined by single-crystal X-ray diffraction analysis, after which the zwitterionic structure was confirmed. The cocrystallization during co-grinding, which was investigated by PXRD, followed first-order kinetics. Furthermore, the solubility of the zwitterionic cocrystals was 7.5-times higher than that of the DFA crystals. The results indicate that the cocrystal is stable under ambient conditions; however, it hydrates and transforms into a mixture of L-proline monohydrate crystals and DFA crystals under conditions of high humidity.

show abstract

Section: Powder Solubility In Watermentioning

confidence: 99%

Zwitterionic cocrystal of diclofenac and l-proline: Structure determination, solubility, kinetics of cocrystallization, and stability study

Nugrahani

Utami

Ibrahim

et al. 2018

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

show abstract

“…Chloropyridines, in particular, are known to be hardly biodegradable and highly toxic to fresh water and marine bacteria [1]. These compounds can be found not only in the effluents of certain industrial activities but also in raw and drinking water due to spills or fugitive emissions [2].…”

Section: Introductionmentioning

confidence: 99%

Photolytic (UVC) and photocatalyic (UVC/TiO2) decomposition of pyridines

Stapleton

Mantzavinos

Papadaki³

2007

Journal of Hazardous Materials

View full text Add to dashboard Cite

“…(Buhler and Reed, 1990). For estuarine sediment microorganisms, median eff ect concentrations (EC50) of pyridine and pyridine deriva-tives were in the range of 0.027-49.1 mmol/L (Liu et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Isolation of a 2-picolinic acid-assimilating bacterium and its proposed degradation pathway

Zheng

Wang

Yan-li

et al. 2017

Bioresource Technology

View full text Add to dashboard Cite

Burkholderia sp. ZD1, aerobically utilizes 2-picolinic acid as a source of carbon, nitrogen and energy, was isolated. ZD1 completely degraded 2-picolinic acid when the initial concentrations ranged from 25 to 300mg/L. Specific growth rate (μ) and specific consumption rate (q) increased continually in the concentration range of 25-100mg/L, and then declined. Based on the Haldane model and Andrew's model, μ and q were calculated as 3.9 and 16.5h, respectively. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) was used to determine the main intermediates in the degradation pathway. Moreover, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) was innovatively used to deduce the ring cleavage mechanism of N-heterocycle of 2-picolinic acid. To our knowledge, this is the first report on not only the utilization of 2-picolinic acid by a Burkholderia sp., but also applying FT-ICR-MS and ATR-FTIR for exploring the biodegradation pathway of organic compounds.

show abstract

Toxicity and anaerobic biodegradability of pyridine and its derivatives under sulfidogenic conditions

Cited by 36 publications

References 36 publications

Zwitterionic cocrystal of diclofenac and l-proline: Structure determination, solubility, kinetics of cocrystallization, and stability study

Zwitterionic cocrystal of diclofenac and l-proline: Structure determination, solubility, kinetics of cocrystallization, and stability study

Photolytic (UVC) and photocatalyic (UVC/TiO2) decomposition of pyridines

Isolation of a 2-picolinic acid-assimilating bacterium and its proposed degradation pathway

Contact Info

Product

Resources

About