Toxicity and Antimicrobial Activity of 6-Chloro-2,4-Diamino- Pyrimidine

Faaz, Rana A.; Al-Zobidy, Adel M. H.; Al-Masoudi, Wasfi A.

doi:10.33762/bvetr.2015.99880

Cited by 1 publication

(2 citation statements)

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“…The results indicated that some of the assayed compounds showed a microbial activity against the used bacterial. As in the figures (7) and (8) and in the Table (5) show Antibacterial activity of some of the prepared compounds. 5): Antibacterial activity of some of the prepared compounds.…”

Section: Biological Activity [18]mentioning

confidence: 96%

“…In 1891, an Italian chemist, P. Biginelli had reported the three components MCR using B-keto esters such as ethyl acetoacetate, aromatic aldehydes such as benzaldehyde, and ureas (or theories) in the presence of an acid catalyst (Brönsted or Lewis acids), affording dihydropyrimidinone derivatives [6]. Dihydropyrimidinones have been paying much attention because of their various bioactivities such as antiinflammatory or anti-bacterial activities [7].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Some Derivatives 1,2,3,4- Tetra Hydro Pyrimidine by Using Three Components Reactions and study the Biological Activity

Yassin Ali,

G. Abed-AL-Kareem

2023

Tikrit J. Pharm. Sci.

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This paper includes a preparation of a number of heterogeneous ring compounds through a three-component reaction methods. The work started with the synthesis of derivatives 1,2,3,4-tetrahydropyrimidine-5-carboxylate [K1-K6] through the reaction of three substances together and at the same time; ethyl acetoacetate, urea, thiourea and benzaldehyde substitutes. Then synthesis of substituted 1,2,3,4-tetrahydropyrimidine-5-carboxylic acid compounds [K7-K12] through the aqueous base hydrolysis reaction of the compounds [K1-K6] with 5% KOH aqueous solution following by neutralize the product with HCl solution. The synthesized compounds were identified by spectral methods: UV, FT-IR and H1- NMR beside melting point and the purity was determined by using (TLC). Some of these compounds are tested against four strains of bacteria (P. aeruginosa and S. aurous).

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Section: Biological Activity [18]mentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%