Toxicity and Antioxidant Activity in Vitro and in Vivo of Two<i>Fucus vesiculosus</i>Extracts

Zaragozá, María Cleofé; López, D.; Sáiz, M. P.; Poquet, Montserrat; Pérez, J.T. Ortiz; Puig-Parellada, P.; Màrmol, Frederic; Simonetti, Paolo; Gardana, Claudio; Lerat, Y.; Burtin, Philippe; Inisan, C.; Rousseau, Ivan; Besnard, Madeleine; Mitjavila, M. T.

doi:10.1021/jf8007053

Cited by 115 publications

(82 citation statements)

References 35 publications

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“…Reactive oxygen species are known to cause cellular damage, which is implicated in the pathogenesis of disorders such as cardiovascular disease, cancer, metabolic syndrome, and type II diabetes. A study by Zaragozá et al (2008) on the antioxidant effect of an extract of Fucus vesiculosus containing 0.0012 % fucoxanthin, found that antioxidant activity increased in ex vivo assays of erythrocytes and plasma, after 4 weeks of daily oral administration in rats. Significant antioxidant activity was also observed in non-cellular systems and in activated RAW 264.7 mouse leukaemic monocyte macrophage cell lines.…”

Section: Introductionmentioning

confidence: 99%

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Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

Shannon¹,

Abu‐Ghannam²

2016

J Appl Phycol

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Fucoxanthin is a xanthophyll pigment which occurs in marine brown algae (Phaeophyceae). The anti-diabetic, anti-obesity, anti-cancer, and antioxidant properties of fucoxanthin have been widely reported. Macroalgae, particularly brown seaweeds, grow prolifically around Irish coasts, representing a valuable resource of nutraceuticals such as fucoxanthin for functional food applications. The aim of this study was to maximise the solvent extraction yield from three anatomically discrete regions of the seaweed thallus: blade, stipe, and holdfast. Response surface methodology was applied to determine optimum parameters for extraction of fucoxanthin from the seaweed, Fucus vesiculosus, as a model species. A central composite design was applied with four extraction variables: time (30-70 min), temperature (30-70°C), solvent pH (5.0-9.0), and percentage acetone (30-70 %). Fucoxanthin content of extracts was quantified by highperformance liquid chromatography. Percentage acetone was found to have the most significant (P = 0.0002) effect on fucoxanthin yield, followed by pH (P = 0.028) and temperature (P = 0.049). Multiple response optimisation determined that fucoxanthin yield from F. vesiculosus may be maximised by incubating at 30.0°C for 36.5 min, pH 5.7, with 62.2 % acetone. Optimised responses were applied to a further nine brown seaweeds; Alaria esculenta, Ascophyllum nodosum, Fucus serratus, Himanthalia elongata, Laminaria digitata, Laminaria hyperborea, Pelvetia canaliculata, Saccharina latissima, and Saccorhiza polyschides. In all species, the blades contained significantly more fucoxanthin than stipes, while holdfasts contained the least. Alaria esculenta blade had the greatest yield (0.870 mg g −1 dry mass), followed by ).

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Section: Introductionmentioning

confidence: 99%

“…The treatment group showed a significant increase in resting energy expenditure and mean weight loss of 4.9 kg after 16 weeks. No toxicity of fucoxanthin extracts has been reported to date, making it an excellent candidate for nutraceutical applications (Maeda et al 2007;Zaragozá et al 2008) (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

Shannon¹,

Abu‐Ghannam²

2016

J Appl Phycol

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“…In spite of several studies on the biological activities of fucans, detailed studies on the toxicology of fucans from different sources are limited. Few studies have shown that some algal fucans are not toxic compounds (Li et al, 2005;Gideon & Rengasamy, 2008;Zaragozá et al, 2008;Chung et al, 2010). However, each new fucan purified from a marine alga is a new compound with unique structures and, consequently, with potential pharmacological and toxicological properties.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of acute and subchronic toxicity of a non-anticoagulant, but antithrombotic algal heterofucan from the Spatoglossum schröederi in Wistar rats

Almeida-Lima¹,

Dantas-Santos²,

Gomes³

et al. 2011

Rev. bras. farmacogn.

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Abstract:Fucan is a term used to denominate a family of sulfated polysaccharides rich in L-fucose. The brown alga Spatoglossum schröederi, Dictyotaceae, synthesizes three heterofucans named A, B, and C. Fucan A is a non-anticoagulant heterofucan which possesses potent antithrombotic (in vivo) and antiproliferative (in vitro) activities. However, its toxicity in vivo has not been determined. The present study examined the acute and subchronic toxicity of the fucan A in Wistar rats after subcutaneous administration. After that, the animals were killed and examined. The results showed in the acute study that fucan A did not cause general adverse effects and mortality in the concentrations 0, 20, 100, 1000, and 2000 µg/g body weight per rat for seven days. Regarding the subchronic study, the data showed that the fucan A did not cause any change in hematological and biochemistry parameters, as well as in the morphology, and in the size of the rat's organs analyzed at a concentration of 20 µg/g body weight per rat during a 62-day period. In conclusion, this study indicates this heterofucan is a compound with potential pharmacological value that has no toxicity in vivo.

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“…In recent years, the consumption of seaweeds has increased many folds because of their beneficial effects and no adversity. The in vitro and in vivo antioxidant activities of edible F. vesiculosus extract were studied Zaragoza et al (2008). The extracts showed no toxicity effects in the acute toxicity studies in mice and rats.…”

Section: Seaweed Antioxidantsmentioning

confidence: 99%

New insights into seaweed polyphenols on glucose homeostasis

Murugan

Karim

Yusoff

et al. 2015

Pharmaceutical Biology

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Context: Polyphenol-rich marine macroalgae are gaining dietary importance due to their influence over diabetes mellitus and the role as a vital source of high-value nutraceuticals. Their assorted beneficial effects on human health include competitive inhibition of digestive enzymes, varying the activity of hepatic glucose-metabolizing enzymes, lowering the plasma glucose levels, and lipid peroxidation, delaying the aging process. Objective: In this paper, we review the health beneficial effects of polyphenols and phlorotannins from brown seaweeds with special emphasis on their inhibitory effects on carbohydrate-metabolizing enzymes. Methods: A survey of literature from databases such as Sciencedirect, Scopus, Pubmed, Springerlink, and Google Scholar from the year 1973 to 2013 was done to bring together the information relating to drug discovery from brown seaweeds as a source for diabetes treatment. Results: Over the past two decades, 20 different bioactive polyphenols/phlorotannins have been isolated and studied from 10 different brown algae. Discussion of the positive effect on the inhibition of enzymes metabolizing carbohydrates in both in vitro and in vivo experiments are included. Conclusion: Despite the recent advancements in isolating bioactive compounds from seaweeds with potential health benefit or pharmaceutical behavior, studies on the polyphenol effectiveness on glucose homeostasis in human beings are very few in response to their functional characterization. Added research in this area is required to confirm the close connection of polyphenol rich seaweed-based diet consumption with glucose homeostasis and the exciting possibility of prescribing polyphenols to treat the diabetes pandemic.

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Toxicity and Antioxidant Activity in Vitro and in Vivo of TwoFucus vesiculosusExtracts

Cited by 115 publications

References 35 publications

Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology

Evaluation of acute and subchronic toxicity of a non-anticoagulant, but antithrombotic algal heterofucan from the Spatoglossum schröederi in Wistar rats

New insights into seaweed polyphenols on glucose homeostasis

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