Toxicity and biocompatibility aspects of dendrimers

Gothwal, Avinash; Malik, Sarita; Gupta, Umesh; Jain, N. K.

doi:10.1016/b978-0-12-814527-2.00011-1

Cited by 20 publications

(12 citation statements)

References 88 publications

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“…administration of ketoprofen with A8 dendrimer demonstrated similar drug absorption and oral path plasma concentration [37]. Commercially available dendrimers of poly-propylenemine (PPI, AstromolR, DAB) [38] and polyamidoamine (PAMAM; Starburstk) have been the most usually explored for pharmacological use [38,39].…”

Section: Dendrimersmentioning

confidence: 99%

Nanomedicines: Nano based Drug Delivery Systems Challenges and Opportunities

Hamid¹,

Manzoor²

2021

Alternative Medicine - Update

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Nanomedicine and nano delivery systems, although relatively recent but fast-developing technology is one where nanoscale materials are used to function as diagnostic tools or to deliver therapeutic agents to specifically targeted sites in a controlled manner. It also provides many advantages in the management of human diseases. Recently, there has been a range of excellent uses of nanomedicine as chemotherapeutic agents, biological agents, immunotherapeutic agents, etc., for treatment of different diseases. In this chapter we discuss the recent developments and insights obtained in the field of nanomedicine. It provides a review of the numerous nano-based drug delivery systems that enhance the efficacy of new and old drugs. The new opportunities and challenges arising in the area of nanomedicine from therapeutic viewpoint are also addressed.

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Section: Dendrimersmentioning

confidence: 99%

Nanomedicines: Nano based Drug Delivery Systems Challenges and Opportunities

Hamid¹,

Manzoor²

2021

Alternative Medicine - Update

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“…Although, in the first generation, the toxicity was due to the open structure and a possible interaction with biological membranes, in the case of newer-generation dendrimers, the steric nucleus prevented these interactions due to the large number of functional groups on the surface [ 204 , 205 ].…”

Section: Dendrimers In Gdept Strategymentioning

confidence: 99%

Section: Dendrimers In Gdept Strategymentioning

confidence: 99%

“…The toxicity profile test is the most important parameter to determine before a product is placed on the market [ 204 ]. Numerous studies, in preclinical and clinical phases, have been performed to detect toxicity and compatibility [ 204 , 206 ]. The modification of functional terminal groups [ 200 ] is considered of interest, particularly by reducing the cationic charge, which is directly responsible for toxicity but also leads to a reduction in therapeutic activity [ 200 , 204 ].…”

Section: Dendrimers In Gdept Strategymentioning

confidence: 99%

“…However, modifying some terminal functional groups [ 208 ], seems to be a viable solution to these problems [ 200 , 202 ]. In addition to these modification techniques, the researchers explored other approaches such as the acetylation of dendrimers that leads to cationic neutralization of the amino group on the functional surface [ 204 ].…”

Section: Dendrimers In Gdept Strategymentioning

confidence: 99%

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Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

et al. 2021

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Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug. In recent years, numerous therapeutic systems based on GDEPT strategy have entered clinical trials. In order to deliver the desired gene at a specific site of action, this therapeutic approach uses vectors divided in two major categories, viral vectors and non-viral vectors, with the latter being represented by chemical delivery agents. There is considerable interest in the development of non-viral vectors due to their decreased immunogenicity, higher specificity, ease of synthesis and greater flexibility for subsequent modulations. Dendrimers used as delivery vehicles offer many advantages, such as: nanoscale size, precise molecular weight, increased solubility, high load capacity, high bioavailability and low immunogenicity. The aim of the present work was to provide a comprehensive overview of the recent advances regarding the use of dendrimers as non-viral carriers in the GDEPT therapy.

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On distance dependent entropy measures of poly propylene imine and zinc porphyrin dendrimers

Wei,

Fahad,

Raza

et al. 2024

Int J of Quantum Chemistry

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A key paradigm in contemporary research is the use of graphs to represent physical systems, molecular structures, or particularly metal frameworks. Graphs are increasingly widely used in a variety of fields, including the study of quantum and molecular systems, macromolecules and their interactions, socioeconomic and ecological systems, and technical and infra‐structural systems. Understanding how these systems function, are robust, and are stable begins with structural characterization. The use of entropies and entropy‐like measurements of graphs/structures of molecules/networks is crucial from both a mathematical and physical standpoint. Several entropy measures of graphs have been defined and studied extensively during the last few decades. The current paper is devoted to investigation of distance dependent entropy measures of Poly Propylene Imine (PPI) dendrimers and Zinc Porphyrin dendrimers. The analytical formulae of distance dependent entropy measures have been developed and their patterns have been presented through graphical tools.

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Toxicity and biocompatibility aspects of dendrimers

Cited by 20 publications

References 88 publications

Nanomedicines: Nano based Drug Delivery Systems Challenges and Opportunities

Nanomedicines: Nano based Drug Delivery Systems Challenges and Opportunities

Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

On distance dependent entropy measures of poly propylene imine and zinc porphyrin dendrimers

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