Toxicity and death following recreational use of 2-pyrrolidino valerophenone

Eiden, Céline; Mathieu, Olivier; Cathala, P.; Debruyne, Danièle; Baccino, E.; Petit, Pierre; Peyrière, Hélène

doi:10.3109/15563650.2013.847187

Cited by 45 publications

(24 citation statements)

References 15 publications

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“…One feature of intoxication with pyrovalerone cathinones is their long duration of insomnia, which can last up to several days (Derungs et al, 2011;Eiden et al, 2013). The long duration of action could be linked to the high potency of the drugs and an increased risk of overdosing.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, MDPV and α-PVP are considered highly addictive (Aarde et al, 2013;Baumann et al, 2013;Watterson et al, 2014). Additionally, intoxication with MDPV, naphyrone, and α-PVP is associated with pronounced agitation, prolonged insomnia, psychotic symptoms, tachycardia, and cardiac arrest (Derungs et al, 2011;Eiden et al, 2013; European Monitoring Center for Drugs and Drug Addiction, 2014b; Spiller et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…In fact, MDPV has become the most frequently detected and used of all cathinones ("bath salts") in some EU countries (Helander et al, 2014;Zuba and Byrska, 2013) and the US (Leffler et al, 2014). More recently, a second generation of MDPV-like cathinones, including α-PVP, MDPPP, and MDPBP, has been detected and/or used in several EU countries (Eiden et al, 2013;Helander et al, 2014;Westphal et al, 2011;Zuba and Byrska, 2013) and the US (Elliott and Evans, 2014;Smollin et al, 2011;Thornton et al, 2012). MDPV has been associated with severe clinical toxicity (Spiller et al, 2011) and a high potential for addiction (Aarde et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, α-PVP has recently been associated with cases of severe acute psychosis and cardiac arrest (Eiden et al, 2013). Pharmacologically, both MDPV and α-PVP are very potent inhibitors of the NET and DAT but not SERT Marusich et al, 2014;Meltzer et al, 2006;Simmler et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Monoamine transporter and receptor interaction profiles of novel psychoactive substances: Para-halogenated amphetamines and pyrovalerone cathinones

Rickli

Hoener

Liechti

2015

European Neuropsychopharmacology

169

188

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The pharmacology of novel psychoactive substances is mostly unknown. We evaluated the transporter and receptor interaction profiles of a series of para-(4)-substituted amphetamines and pyrovalerone cathinones. We tested the potency of these compounds to inhibit the norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters (NET, DAT, and SERT, respectively) using human embryonic kidney 293 cells that express the respective human transporters. We also tested the substance-induced efflux of NE, DA, and 5-HT from monoamine-loaded cells, binding affinities to monoamine receptors, and 5-HT 2B receptor activation.Para- (4)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Monoamine transporter and receptor interaction profiles of novel psychoactive substances: Para-halogenated amphetamines and pyrovalerone cathinones

Rickli

Hoener

Liechti

2015

European Neuropsychopharmacology

169

188

View full text Add to dashboard Cite

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“…These reports suggest that the dose of 4-MeOPBP in this case may have been high enough to cause severe acute toxicity. Tachycardia and cardiac arrest were observed in the previous apyrrolidinophenone derivative poisoning cases [8,9,17]; therefore, a similar cardiac event might have led to drowning in this case.…”

Section: Quantification Of 4-meopbp In Plasma and Urine Samplesmentioning

confidence: 61%

Identification and quantification of 4′-methoxy-α-pyrrolidinobutiophenone (4-MeOPBP) in human plasma and urine using LC–TOF-MS in an autopsy case

et al. 2015

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We encountered an autopsy case of a 35-yearold man who drowned in a bathtub. Nine opened packages of designer drugs containing herbal blends, powders, or liquid were found at the scene, implying abuse. The plasma and urine samples of the deceased were analyzed using liquid chromatography-time-of-flight-mass spectrometry (LC-TOF-MS) with MS E . A new synthetic cathinone, 4 0 -methoxy-a-pyrrolidinobutiophenone (4-MeOPBP), emerged as a suspected component via elemental composition and molecular structure analyses with acquisition of full spectra of the precursor and product ions by MS E mode. The component was finally identified by comparing the mass spectra obtained from the deceased's samples with those of the reference standard 4-MeOPBP using LC-TOF-MS and gas chromatography-mass spectrometry. Furthermore, 4-MeOPBP was the main component of an opened package labeled ''Silver Snow''. The concentrations of 4-MeOPBP in plasma and urine samples were as high as 9.5 and 12 lg/ml, respectively. To our knowledge, this is the first report disclosing 4-MeOPBP in human specimens.

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Intended and unintended use of cathinone mixtures

Guirguis

Corkery

Stair

et al. 2017

Human Psychopharmacology

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Introduction Cathinones are one of the most popular categories of new psychoactive substances (NPS) consumed. Cathinones have different pharmacological activities and receptor selectivity for monoamine transporters based on their chemical structures. They are incorporated into NPS mixtures and used with other NPS or ‘traditional’ drugs. Cathinone use represents significant health risks to individuals and is a public health burden. Methods Evidence of poly‐NPS use with cathinones, seizure information, and literature analyses results on NPS mixtures was systematically gathered from online database sources, including Google Scholar, Scopus, Bluelight, and Drugs‐Forum. Results and discussion Results highlight the prevalence of NPS with low purity, incorporation of cathinones into NPS mixtures since 2008, and multiple members of the cathinone family being present in individual UK‐seized samples. Cathinones were identified as adulterants in NPS marketed as being pure NPS, drugs of abuse, branded products, herbal blends, and products labelled “not for human consumption.” Toxicity resulting from cathinone mixtures is unpredictable because key attributes remain largely unknown. Symptoms of intoxication include neuro‐psychological, psychiatric, and metabolic symptoms. Proposed treatment includes holistic approaches involving psychosocial, psychiatric and pharmacological interventions. Conclusion Raising awareness of NPS, education, and training of health care professionals are paramount in reducing harms related to cathinone use.

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Toxicity and death following recreational use of 2-pyrrolidino valerophenone

Cited by 45 publications

References 15 publications

Monoamine transporter and receptor interaction profiles of novel psychoactive substances: Para-halogenated amphetamines and pyrovalerone cathinones

Monoamine transporter and receptor interaction profiles of novel psychoactive substances: Para-halogenated amphetamines and pyrovalerone cathinones

Identification and quantification of 4′-methoxy-α-pyrrolidinobutiophenone (4-MeOPBP) in human plasma and urine using LC–TOF-MS in an autopsy case

Intended and unintended use of cathinone mixtures

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