Toxicity and detoxification of monocrotophos from ecosystem using different approaches: A review

Singh, Simranjeet; Kumar, Vijay; Kanwar, Rameshwar S.; Wani, Abdul Basit; Gill, Jatinder Pal Kaur; Garg, V.K.; Singh, Joginder; Ramamurthy, Praveen C.

doi:10.1016/j.chemosphere.2021.130051

Cited by 28 publications

(6 citation statements)

References 75 publications

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“…Similarly, it was reported that MCP exposure was responsible for 22.2% of mortalities associated with pesticide poising in Brazil. It is estimated that in India, MCP is majorly used and its exposure is involved in the maximum numbers of mortality by poisoning [ 15 , 16 ].The liver has long been considered as a major target organ of MCP-induced toxicity [ 17 , 18 ]. Studies have demonstrated that MCP exposure induces morphological and physiological changes in the liver [ 17 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats

et al. 2021

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Oxidative stress-mediated tissue damage is primarily involved in hepatic injuries and dysfunctioning. Natural antioxidants have been shown to exert hepatoprotective, anti-inflammatory and antiapoptotic properties. The present study evaluated the effect of N-acetylcysteine (NAC) against monocrotophos (MCP) exposure-induced toxicity in the rat liver. Albino Wistar rats were divided into four groups: (1) control, (2) NAC-treated, (3) MCP-exposure, (4) NAC and MCP-coexposure group. The dose of MCP (0.9 mg/kg b.wt) and NAC (200 mg/kg b.wt) were administered orally for 28 days. Exposure to MCP caused a significant increase in lipid peroxidation, protein oxidation and decreased glutathione content along with the depletion of antioxidant enzyme activities. Further MCP exposure increased pro-inflammatory cytokines levels and upregulated Bax and Caspase-3 expressions. MCP exposure also caused an array of structural alternations in liver tissue, as depicted by the histological and electron microscopic analysis. Thepretreatment of NAC improved glutathione content, restored antioxidant enzyme activities, prevented oxidation of lipids and proteins, decreased pro-inflammatory cytokines levels and normalized apoptotic protein expression. Treatment of NAC also prevented histological and ultrastructural alternations. Thus, the study represents the therapeutic efficacy and antioxidant potential of NAC against MCP exposure in the rat liver.

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Section: Introductionmentioning

confidence: 99%

N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats

et al. 2021

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“…Despite its restricted to use a label, its unplanned application in agriculture is responsible for environmental exposure to humans and mammals. The residue of MCP have been reported in fruits, vegetables, dairy products, soil and water (Leuthold 2013;Mishra 2013;Kumar et al 2014;Singh et al 2021). Monocrotophos exposure is known to induce oxidative stress, reduction of antioxidant levels and causes apoptosis that could lead to multi-organ failure and genetic alterations (Velmurugan et al 2013;Sankhwar et al 2016;Mandal et al 2020).…”

Section: Discussionmentioning

confidence: 99%

N-Acetylcysteine Attenuates Monocrotophos-induced Toxicity by Mitigating Oxidative Stress and Structural Changes in Rat Liver

Singh

Phogat

Prakash

et al. 2021

Preprint

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The present study evaluated the effect of N-acetylcysteine (NAC) against sub chronic monocrotophos (MCP) exposure induced oxidative stress in rat liver. Albino wistar rats were divided into control, NAC treated, MCP and MCP treated groups. An oral dose of MCP (0.9 mg/kg b.wt) and NAC (200 mg/kg b.wt) was administered for 28 days. We observed high oxidative stress generation on MCP exposure in liver tissue as evident by significant increase in lipid peroxidation, protein oxidation and decreased glutathione content followed by altered activities of superoxide dismutase, catalase and acetylcholinesterase. Sub chronic MCP exposure caused an array of cellular and structural alternations in lipids and proteins of liver tissue as depicted by the FTIR, histopathological and electron microscopic analysis. N-acetylcysteine attenuated the loss of glutathione and prevented lipid peroxidation and protein oxidation. Pre-treatment of NAC also restored histological and ultra space structural alternations. So NAC protects oxidative stress and tissue damage induced by sub chronic MCP exposure in rat liver; suggesting the therapeutic and antioxidant potential of NAC.

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“…21 Monocrotophos is widely applied on cotton, rice, and sugarcane. 22 The agricultural fields surrounding the lake dominates in the cotton plantation. Being readily soluble in water and reduced sorption in soil, it leaches into the ground water and may contaminate the water.…”

Section: Isolation and Molecular Identification Of Most Dominant Cyan...mentioning

confidence: 99%

Impacts of Agricultural Practices (Pesticides and Fertilizers) and Amalnala Stream on Amalnala Lake in Gadchandur, India

Moon,

Durge,

Wadhai

2024

J. Pure Appl. Microbiol.

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Amalnala lake is situated in the Gadchandur town of Chandrapur district in Maharashtra, India. The lake water was turning green in colour in the month of september. This study gives an insight into the causes and factors responsible for the greening of the lake adjacent to Manikgarh limestone mine in the month of September. It was noted that, phosphate concentration in lake water showed rise after July (2020, 2021) and peaked in August (2020, 2021). The phosphates were mainly contributed by organophosphate pesticides such as monocrotophos, profenofos, and chlorpyrifos, which were identified by liquid chromatography triple quadrupole mass spectrometry (LC MS/MS). The rise in phosphates showed complete correlation with the rainfall and chlorophyl a (chl a) content in September (2020, 2021). Similarly, the nitrate concentration of the lake showed peak in August (2020, 2021) followed by the rise in chl a content in September (2020, 2021). Chemical oxygen demand (COD) and biological oxygen demand (BOD) of the lake was calculated and represented in terms of COD/BOD. The COD/BOD were highest in September (2020, 2021). Positive correlation was observed between the pH, total dissolved solids, and electrical conductivity of Amalnala Lake and Amalnala Stream which flows into the lake. This stream mainly carries the contaminants from open cast Manikgarh limestone mines to Amalnala Lake. Chl a was mainly contributed by two dominant species of cyanobacteria, Phormidium species CCALA 726 which was identified by 16S rRNA sequencing and Microcystis aeruginosa which was identified by using the keys given by Desikachary and Komarek and Anagnostidis. This study thus concluded that the pesticides, nitrates, and Amalnala Stream contributed in the growth of cyanobacteria which causes the greening of the lake.

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Toxicity and detoxification of monocrotophos from ecosystem using different approaches: A review

Cited by 28 publications

References 75 publications

N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats

N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats

N-Acetylcysteine Attenuates Monocrotophos-induced Toxicity by Mitigating Oxidative Stress and Structural Changes in Rat Liver

Impacts of Agricultural Practices (Pesticides and Fertilizers) and Amalnala Stream on Amalnala Lake in Gadchandur, India

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