Toxicity and efficacy of accelerated radiotherapy with concurrent weekly cisplatin for locally advanced head and neck carcinoma

Abstract

Concomitant weekly cisplatin 40 mg/m(2) with accelerated RT was well tolerated and treatment compliance was high. © 2015 Wiley Periodicals, Inc. Head Neck 38: E559-E565, 2016.

Artificial nutrition dependence after cetuximab versus cisplatin combined with radiotherapy for advanced head and neck cancer: A propensity score–matched analysis

“…In previous studies, the proportions of patients with enteral nutrition dependence varied widely, from 36% to 78% after CCRT and from 38% to 79% after cetuximab‐based RT . The proportion of patients who failed to wean from artificial nutrition has been reported as 22% with both cetuximab‐based RT and CCRT at 30 days after the end of treatment .…”

“…A previous study showed that CCRT increased the risk of enteral nutrition dependence at 6 months compared to cetuximab‐based RT . The proportion of patients receiving the PEG procedure during hospitalization was reported as 50% to 55% in cetuximab‐based RT and 69% to 78% in CCRT . Previous studies reported that enteral nutrition dependence was significantly associated with advanced tumor classification, severe weight loss (>10% from baseline), chemoradiotherapy, and high doses of RT .…”

“…Cetuximab‐based RT is likely to be initiated in patients unsuitable for CCRT for reasons of age (>70 years), impaired organ function, or poor performance status in a practical setting . Nevertheless, previous studies have not accounted for differences in patient characteristics between cetuximab‐based RT and CCRT.…”

Degree of nephrotoxicity after intermediate‐ or high‐dose cisplatin‐based chemoradiotherapy in patients with locally advanced head and neck cancer

“…Patients with postoperative locally advanced head and neck cancer and NPC received cisplatin 100 mg/m 2 every 3 weeks in combination with conventional radiotherapy. Patients who were primarily treated with concomitant chemoradiotherapy received weekly cisplatin 40 mg/m 2 in combination with accelerated radiotherapy . From 2003 until 2006, a 3D‐conformal radiotherapy technique was used.…”

“…Although very effective, this treatment is associated with high rates of acute toxicity. An alternative treatment schedule is radiotherapy with weekly cisplatin 40 m/m 2 with good feasibility and efficacy …”