Toxicity and phytochemical properties of southern African medicinal plants used traditionally to treat pain and inflammatory ailments

: Multidrug resistance is becoming a global concern as the new generations of antimicrobials are showing resistance to pathogens. Therefore, alternative treatment of multidrug resistance with natural products is very much necessary to combat this worldwide problem. This study involved the in-silico approach of finding the antimicrobial potent phytocompounds of the plant against the multidrug-resistant pathogens of head and neck infection.(OP889672), (OP889575), and (OR345133) were the isolated microorganisms from head and neck infections. The antimicrobial susceptibility pattern of these strains was performed through the Vitek 2 procedure. To perform the molecular docking analysis, ligands (phytocompounds) were retrieved from PubChem, and the 3D structure of target proteins was retrieved from the SWISS Model. Then to know the binding affinities of the phytocompounds of molecular docking was performed with the target proteins.The antimicrobial susceptibility pattern of the three strains revealed most of the antimicrobials are resistant to their respective pathogens.The molecular docking analysis found that γ-Sitosterol, Stigmasterol, and β-Amyrin, had the highest binding affinities with the target proteins followed by Lupeol.The phytocompounds of have the potency to inhibit multidrug resistance pathogens of head and neck infection and could be utilized further as therapeutic agents.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Toxicity and phytochemical properties of southern African medicinal plants used traditionally to treat pain and inflammatory ailments

Cited by 2 publications

References 129 publications

The in vitro cytotoxicity, genotoxicity and LC-ToF-MS profiling of four South African plants with good antifungal activity

The in vitro cytotoxicity, genotoxicity and LC-ToF-MS profiling of four South African plants with good antifungal activity

Molecular docking studies of phytocompounds of Coccinia grandis to inhibit antimicrobial-resistant pathogens of head and neck infection

Contact Info

Product

Resources

About