Toxicity assessment due to prenatal and lactational exposure to lead, cadmium and mercury mixtures

Zhou, Fankun; Yin, Guangming; Gao, Yanyan; Liu, Dong; Xie, Jie; Ouyang, Li; Fan, Ying; Yu, Han; Zha, Zhipeng; Wang, Kai; Shao, Longquan; Feng, Chenglian; Fan, Guang

doi:10.1016/j.envint.2019.105192

Cited by 77 publications

(41 citation statements)

References 50 publications

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“…Short-term Pb exposure caused significant alteration in morphological features of liver and gastrocnemius muscle of mice as indicated by deformed central vein with fragmented sinusoids, degenerated hepatocytes, and enlarged nuclei in liver sections of Pb-treated mice. These findings are supported by earlier observations of Zhou et al (2019) who reported alterations in liver architecture on exposure to Pb containing metal mixture in prenatal and lactation stages of life. Additionally, the skeletal muscle architecture was markedly distorted by Pb as evidenced by squeezing of muscle fibers along with disruption of normal striations following Pb exposure.…”

Section: Discussionsupporting

confidence: 91%

Metabolic adaptability in liver and gastrocnemius muscle of mice following subacute lead toxicity

2020

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Lead (Pb) is one of several environmental pollutants that adversely affect human health by producing toxicity at the tissue level. The aim of the study was to understand the effects of Pb on the metabolic profiles of liver and gastrocnemius muscle of mice in relation to carbohydrate and fat metabolisms. Swiss albino mice were chosen and divided into two groups, control and Pb-treated. The Pb-treated animals were exposed to Pb at a dose of 5 mg/kg body weight for 30 days orally, which resulted in hypoglycemia, glycosuria, and increased glycogenolysis in the liver and gastrocnemius muscle of treated mice. Pyruvic acid, the end product of glycolysis decreased in muscular tissue and increased in the liver. Additionally, the activity of G-6Pase was depressed in the liver, whereas lactate dehydrogenase activity was increased in skeletal muscle only. An adaptive mechanism was initiated by stimulating glycogenolytic and retarding glycolytic activity in the liver and also by alteration of liver and muscle pyruvate dehydrogenase activity along with increased activity of malate dehydrogenase in skeletal muscle. There was enhancement of succinate dehydrogenase and nicotinamide adenine dinucleotide phosphate oxidase activities in the studied tissues. Interestingly, cholesterol, high-density lipoprotein, and low-density lipoprotein levels were elevated, whereas those of triglycerides were decreased in Pb-treated mice serum. The activities of fatty acid synthase and glyceraldehyde 3 phosphate dehydrogenase were depressed in Pb-treated mice livers. Pb also significantly altered the morphological features of the liver, skeletal muscle, and pancreas. These data suggested that subacute Pb exposure was responsible for metabolic modulation in an adaptive fashion in the liver and skeletal muscle of mice.

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Section: Discussionsupporting

confidence: 91%

Metabolic adaptability in liver and gastrocnemius muscle of mice following subacute lead toxicity

2020

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“…Rtęć jest jednym z metali ciężkich, zaliczanych do dziesięciu czołowych zanieczyszczeń [2]. Jony rtęci wykazują działanie toksyczne, głównie za sprawą swojego silnie utleniającego charakteru oraz interakcji z grupami sulfhydrylowymi.…”

Section: Wstępunclassified

Occurrence of mercury in various types of honey

Brodziak-Dopierała¹,

Mendak-Oleś²,

Fischer³

2021

Med Srod.

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Wprowadzenie i cel pracy. Medycyna naturalna w obecnych czasach przeżywa dynamiczny rozkwit. Uważana jest w większości za tanią, łatwo dostępną i bezpieczną. Należy do niej apiterapia -leczenie z wykorzystaniem surowców pszczelich (propolis, miód). Surowce te wytwarzane są przez pszczoły, które wykorzystują w tym celu różne rodzaje roślin, co niesie ryzyko, iż są one zanieczyszczone metalami ciężkimi, w tym rtęcią. Celem niniejszej pracy było określenie zawartości rtęci w różnych rodzajach miodów. Oszacowano ilość rtęci pobranej podczas spożycia badanych miodów. Materiał i metody. W badaniach wykorzystano 32 próbek miodów zebranych na terenie Polski w obrębie kilku województw: lubuskiego, małopolskiego, śląskiego, podkarpackiego i świętokrzyskiego. Były to różne rodzaje miodów. Z każdej próbki odważono łącznie 100 mg miodu i oznaczono zawartość rtęci z wykorzystaniem spektrometru absorpcji atomowej AMA 254. Wyniki. Badania wykazały, że rtęć była obecna we wszystkich próbkach poddanych analizie. Średnia zawartość rtęci w próbkach wynosiła 0,37 µg/kg. Największą ilość rtęci oznaczono w miodzie spadziowym -1,55 µg/kg, a najmniejszą w miodzie nawłociowym -0,02 µg/kg. Wyliczono dzienną dawkę rtęci dostarczaną z pożywieniem. W żadnym z przypadków nie została przekroczona wartość tolerowanego dziennego pobrania (TWI). Wnioski. W badanych próbkach miodów nie została przekroczona dopuszczalna zawartość rtęci. Ze względu na wciąż rosnące zanieczyszczenie środowiska konieczne jest dokładniejsze monitorowanie zawartości rtęci w miodach i innych produktach pszczelich, aby zapewnione było całkowite bezpieczeństwo spożywania ich przez ludzi.

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“…There are more and more reports of the possible contamination of honey and other bee products [2][3][4][5]. Mercury (Hg) is a heavy metal listed among the top 10 contaminants [6]. When in a methylated form, its capacity to penetrate the biological barriers of the human organism is high [7].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Mercury Concentration in Honey from the Point of View of Human Body Exposure

Fischer

Brodziak-Dopierała

Bem

et al. 2021

Biol Trace Elem Res

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Honey is a highly valued product due to its nutritional value, pro-health and healing properties. Pollutants from the environment penetrate into nectar, honeydew, pollen and next into bee products and can cause human exposure after ingestion. Mercury (Hg) is a toxic metal to living organisms. This is why it was important to determine the level of Hg in consumed honey.The aim of this manuscript is to analyse mercury concentration in honeys collected on the territory of Poland. A total of 108 samples of honey purchased in regional apiaries and hypermarkets were tested. The concentration of Hg was analysed in various types of honey (multifloral, honeydew, linden, goldenrod, acacia, buckwheat, rapeseed, sunflower, heather, dandelion, phacelia). The values of the Estimated Daily Intake (EDI), Estimated Weekly Intake (EWI) and % Provisional Tolerable Weekly Intake (% PTWI) were calculated. This allowed estimating the amount of Hg taken during consumption of the tested honeys.The concentration of Hg ranged from 0.01 to 1.71 µg/kg and was 0.43 µg/kg on average. A higher concentration of Hg, which was statistically significant, was recorded in honeydew honey, then in compound honeys. Honeys produced from one raw material had the lowest concentration of Hg. There were no significant differences in the concentration of Hg depending on the origin of honey. The calculations have shown that consumption of a portion (19 g) of the tested honey per week is safe for both adults and children according to the applicable standards.

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Toxicity assessment due to prenatal and lactational exposure to lead, cadmium and mercury mixtures

Cited by 77 publications

References 50 publications

Metabolic adaptability in liver and gastrocnemius muscle of mice following subacute lead toxicity

Metabolic adaptability in liver and gastrocnemius muscle of mice following subacute lead toxicity

Occurrence of mercury in various types of honey

Analysis of Mercury Concentration in Honey from the Point of View of Human Body Exposure

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