“…Indeed, they have been used as T 2 contrast agents for MRI, [8][9][10] they are known to have a limited toxicity and to be degraded within cells, being then less toxic to the organism as compared to other magnetic nanomaterials. [6,[11][12][13][14] For instance, these external fields-responsive IO NPs show great promise as new theranostics for localized and remotely activated magnetic hyperthermia therapy [15][16][17][18] which may be followed with MRI. Upon alternating magnetic field application, they produce a local heat which is used for tumor treatment by magnetic field induced hyperthermia.…”