Toxicity assessment of nanoparticles in contact with the skin

Zaiter, Taghrid; Cornu, Raphaël; Basset, Wassim El; Heidegger, Martín; Diab, Mona; Béduneau, Arnaud

doi:10.1007/s11051-022-05523-2

Cited by 15 publications

(7 citation statements)

References 87 publications

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“…123 Accumulated research data indicate that the cytotoxicity of MeOx NPs and Cu NPs in a wide variety of cells is mediated by excessive ROS production and subsequent oxidative stress. 124,125 iii) Activation of apoptotic signaling pathways. In addition to ROS production, NM–mitochondria interaction induces the activation of apoptosis signaling pathways featured in the release of cytochrome C and activation of proteolytic enzymes, leading to cell death.…”

Section: Key Molecular Events Of Enm Toxicity At the Nano-skin Interf...mentioning

confidence: 99%

“…, HaCaT, HDFs, HEK, MNT-1) and few in co-cultures of HaCaT cells and primary human skin fibroblasts. 125 The cell viability can be determined by a variety of methods, e.g. , MTT, XTT, MTS, WST1, Alamar Blue, calcein AM, LDH release assay, and G6PD release, whereas the results can be greatly influenced by the cell lines and experimental conditions.…”

Section: Key Molecular Events Of Enm Toxicity At the Nano-skin Interf...mentioning

confidence: 99%

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The nanosafety assessment of ENMs under a dermal exposure scenario: from key molecular events toin silicomodeling tools

Xie,

Xiong,

Wang

et al. 2024

Environ. Sci.: Nano

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Section: Key Molecular Events Of Enm Toxicity At the Nano-skin Interf...mentioning

confidence: 99%

Section: Key Molecular Events Of Enm Toxicity At the Nano-skin Interf...mentioning

confidence: 99%

The nanosafety assessment of ENMs under a dermal exposure scenario: from key molecular events toin silicomodeling tools

Xie,

Xiong,

Wang

et al. 2024

Environ. Sci.: Nano

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“…Follicle area is considered the best site for particle storage as it is not exposed to washing or fabric contact. This area is considered suitable for drug release and a shortcut to the systemic circulation [5,6].…”

Section: Skin As the Entry Routementioning

confidence: 99%

Toxicity Evaluation and Biocompatibility of Nanostructured Biomaterials

Thomas¹,

Varghese²,

Kalarikkal³

et al. 2023

Cytotoxicity - Understanding Cellular Damage and Response

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Biomaterials have occupied a prominent place in regenerative procedures to restore human health. Moreover, there is a greater need in understanding, analyzing and establishing their toxicity profile. These, when made into nano-sized constructions called nanostructured biomaterials, their regenerative potential is enhanced, which could influence their toxicity nature. This chapter intends to give comprehensive information on their nanotoxicology pathways at the cellular level, their entry pathways into the human body, and their potential consequences on human health. It clearly explains the cytocompatibility and biocompatibility of various nanostructured biomaterials for potential human health applications like drug delivery and tissue engineering. A detailed overview of various in vitro and in vivo evaluation methods of biocompatibility of nanomaterials are outlined in this chapter that researchers should address as they move forward in developing new systems for the field of regeneration.

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“…A limited number of studies described the toxicological effects of MNPs (Ag, Au, Silica) on cutaneous cells including cytotoxicity, inflammatory response and genotoxicity [7]. These effects were correlated mainly with oxidative stress production and pro-inflammatory cytokines release.…”

Section: Introductionmentioning

confidence: 99%

A SP-ICP-MS protocol for the detection of metal nanoparticles composition and size in tattooed ex vivo human skin explants

Bocca,

Caimi,

Failla

et al. 2023

J. Phys.: Conf. Ser.

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We developed and validated a protocol based on Single Particle Inductively Coupled Plasma Mass Spectrometry (SP ICP-MS) to detect composition and size of metal nanoparticles (MNPs) in tattoo inks end ex vivo tattooed human skin explants. The explants were tattooed with different inks using an ordinary tattoo machine. Then, 72 hours after tattooing, skin explants were subjected to alkaline extraction by tetramethylammonium hydroxide solution and MNPs of Ag, Al2O3, Au, Cr2O3, CuO, Fe2O3, TiO2 and ZnO were analysed for particle composition and size by SP ICP-MS. The method was validated by assessing the limit of detection, accuracy, precision, and size stability over 72 hours. Particles of Al2O3, Cr2O3, CuO, Fe2O3, TiO2 and ZnO were observed in human skin in the range from 27 nm to 153 nm, and from 26 nm to 228 nm in tattoo inks. Ag and Au NPs were not found neither in inks nor in the skin. Advantages of the protocol were the ability to simultaneously detect the composition of particles and their size, the straightforward sample preparation, the high sensitivity and precision, and the speed of execution of the analysis. The developed methodology can be applied to skin exposed to other consumer products topically applied, such as sunscreens, cosmetics, personal care products and medical devices, which can be all sources of MNPs, in order to improve knowledge and support the human exposure assessment process.

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Toxicity assessment of nanoparticles in contact with the skin

Cited by 15 publications

References 87 publications

The nanosafety assessment of ENMs under a dermal exposure scenario: from key molecular events toin silicomodeling tools

The nanosafety assessment of ENMs under a dermal exposure scenario: from key molecular events toin silicomodeling tools

Toxicity Evaluation and Biocompatibility of Nanostructured Biomaterials

A SP-ICP-MS protocol for the detection of metal nanoparticles composition and size in tattooed ex vivo human skin explants

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