Toxicity, cytotoxicity, mutagenicity and in vitro antioxidant models of 2-oleyl-1,3-dipalmitoyl-glycerol isolated from the hexane extract of Platonia insignis MART seeds

Cavalcante, Antônio do Nascimento; Lima, Layana Karine Farias; Araújo, Cristiany Marinho; Santos, Felipe Pereira da Silva; Nascimento, Matheus Oliveira do; Sousa, João Marcelo de Castro e; Rai, Mahendra; Feitosa, Chistiane Mendes

doi:10.1016/j.toxrep.2020.01.014

Cited by 11 publications

(8 citation statements)

References 47 publications

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“…Antioxidants act as a defense mechanism against the reactive species derived from oxygen and nitrogen by reducing the oxidative damage to the tissues [ 9 ]. Superoxide dismutase (SOD) and catalase (CAT) both have significant roles as antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect

et al. 2021

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“…Moreover, due to the health-promoting effects of most plant-based products [11], the oral use of bitters which are poly-herbal formulations, in the form of herbal cocktail mixtures, has emerged over the years. In recent times, these bitters, such as Swedish bitters, Yoyo bitters, Alomo bitters, and Orijin, to mention a few, are chiefly consumed for their medicinal benefits.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Impact of Carica Papaya (Pawpaw) leaves Extract and Ruzu Bitters on Hematology and Brain Histology in Sprague Dawley Rats

Ebuehi¹,

Ayobami²,

Ajagun-Ogunleye³

2023

Recent Prog Nutr

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Plant-based products have been utilized for nutritional and medicinal purposes for decades. Although the reported benefits of Carica papaya (Pawpaw) leave extract, its role in hematology, brain histology, and the possible side effect are still areas of research deliberation. Thirty (30) male Sprague Dawley rats, divided into three groups, were fed on rat chow and normal saline, Carica papaya leaves extract and Ruzu bitters, respectively. Blood chemistry, hematology, and brain histology were assayed to ascertain their effects on brain structure and biochemical changes. White blood cells, hemoglobin, red blood cells, platelets, and packed cell volume were carefully evaluated. In the sub-chronic test, there were no significant changes in PCV (%) in the papaya extract and Ruzu bitters group, relative to the control. There was a significant increase in hemoglobin levels in the papaya and Ruzu bitters groups. Carica papaya leaves extract and Ruzu bitters significantly increased certain serum biochemistry parameters (p < 0.05), compared to the control group. Our study revealed that C. papaya leaves extract possess an immunomodulatory effect and did not show any detrimental effect on the brain histology, liver, and general well-being, unlike Ruzu bitters. The neuroprotective effect of the extract is apparent from the intact brain structure of treated rats compared to the other group, (p < 0.05). The hydro-ethanol leaf extract of Carica papaya possesses neuroprotective, anti-inflammatory, anti-hemolytic and immunomodulatory effects compared to the Ruzu bitters. However, both extracts’ long-term administration should be taken cautiously and further investigated.

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“…is a plant typical of Cerrado, belonging to the family Clusiaceae and to the genus Platonia [ 18 , 19 ], and has been used in folk medicine in the treatment of diarrhea [ 20 ], wounds, and other skin conditions [ 21 ]. Some studies have investigated different biological activities of bacuri, and they are identified as antioxidant [ 22 , 23 ], anti-inflammatory [ 24 ], wound healing [ 25 , 26 ], anticonvulsant [ 27 , 28 ], antileishmanial [ 18 , 29 , 30 ], and immunomodulatory [ 31 ], among other effects. Moreover, formulation of bacuri-based functional products is being investigated [ 24 , 26 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of “Bacuri” Seed Butter (Platonia insignis Mart.) on Metabolic Parameters in Hamsters with Diet-Induced Hypercholesterolemia

Lima

Brito

Farias

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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This study aimed to evaluate the effects of the treatment with bacuri seed butter (BB) on body weight, growth, body mass index, lipid profile, atherosclerotic indices, and liver function in dyslipidemic hamsters. Freshly weaned, male hamsters were divided into four groups: (1) normal group (NG)—maintained with standard chow (AIN-93G); (2) dyslipidemia group (DG)—maintained with hyperlipidemic chow (AIN-93G modified) throughout the follow-up period; (3) bacuri seed butter 25 mg/kg/day (BB-25); and (4) bacuri seed butter 50 mg/kg/day (BB-50). BB groups (25 and 50 mg/kg/day) were also maintained with hyperlipidemic chow throughout the follow-up period, and the treatment started after 21 days receiving a hyperlipidemic diet to induce hypercholesterolemia and maintained for 28 days. No significant differences in triglycerides and total cholesterol were observed for BB-25 and BB-50 groups when compared with NG and DG groups. On the contrary, BB-25 and BB-50 induced both increase of HDL-c (51.40 ± 1.69 and 51.00 ± 2.34, respectively) and decrease of LDL-c (103.80 ± 6.87 and 100.50 ± 3.95, respectively) when compared with DG (41.00 ± 2.94 and 132.70 ± 9.41, respectively). In addition, BB promoted a reduction in the risk of atherosclerotic disease by decreasing p < 0.05 the atherogenic index, coronary artery risk index, and LDL/CT ratio p < 0.05 and increasing HDL/CT ratio. On the contrary, no changes were observed in total cholesterol and triglyceride levels or in body weight, growth, body mass index, or liver function parameters. Thus, bacuri seed butter at doses of 25 and 50 mg/kg/day has positive repercussions on the lipid profile, more precisely on plasma HDL-c and LDL-c, and additionally promotes reduction in the risk of atherosclerosis in hamsters.

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Toxicity, cytotoxicity, mutagenicity and in vitro antioxidant models of 2-oleyl-1,3-dipalmitoyl-glycerol isolated from the hexane extract of Platonia insignis MART seeds

Cited by 11 publications

References 47 publications

Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect

Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect

Biochemical Impact of Carica Papaya (Pawpaw) leaves Extract and Ruzu Bitters on Hematology and Brain Histology in Sprague Dawley Rats

Effects of “Bacuri” Seed Butter (Platonia insignis Mart.) on Metabolic Parameters in Hamsters with Diet-Induced Hypercholesterolemia

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