Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats

Onyeka, Ifeanyi Peter; Сулейман, М. М.; Bako, Sunday

doi:10.4172/2472-0992.1000147

Cited by 10 publications

(16 citation statements)

References 13 publications

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“…Plant extracts showed the presence of phytoconstituents such as phenolics, tannins, flavonoids, saponins and terpenoids. This result is similar with reports by Onyeka et al (2018) and Gupta and Gupta (2019) that both reported presence of phenolics, tannins, flavonoids, saponins and terpenoids in E. hirta. The result of the phytochemical screening of honey revealed that constituents such as saponins, steroids, glycosides, and flavonoids were present.…”

Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas / 588supporting

confidence: 93%

Structural elucidation, mechanism of action, antibacterial proficiency and synergistic forte of purified Euphorbia hirta whole plant extract against multi-drug resistant otitis media infection

Oseni¹,

Olusola-Makinde²,

Oladunmoye³

2021

BLACPMA

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This study investigated the antibacterial potential of Euphorbia hirta whole plant extracts, honey and conventional antibiotics and their synergistic effects against selected multidrug resistant and typed bacterial strains associated with otitis media. E. hirta whole plant extract was purified using column chromatography technique. The antibacterial assays of extracts were done using standard microbiological procedures. Protein, sodium and potassium ion leakage of the synergistic mixtures was determined using flame-photometry. At 100 mg/ml, acetone extracts presented highest inhibition against S. aureus (NCTC 6571) with 32 ± 0.83 mm zone of inhibition. The fractional inhibitory concentration indices displayed higher synergism in combination of plant extract, honey and ciprofloxacin against P. mirabilis at 0.02 compared to drug combination synergy standard (≤ 0.5). This work revealed augmentation of ciprofloxacin potency when combined with purified E. hirta acetone extract and honey and implies their high potential in the treatment of multidrug resistant infection of otitis media.

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Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas / 588supporting

confidence: 93%

Structural elucidation, mechanism of action, antibacterial proficiency and synergistic forte of purified Euphorbia hirta whole plant extract against multi-drug resistant otitis media infection

Oseni¹,

Olusola-Makinde²,

Oladunmoye³

2021

BLACPMA

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“…The result of the acute toxicity studies is presented in Table 2 . It showed that the LD 50 of E. hirta is above 5000 mg/kg of crude extract because no death was recorded above 5000 mg/kg in the rats [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Antiulcer Effects of Methanol Extract of Euphorbia hirta and Honey Combination in Rats

Onyeka

Bako

Сулейман

et al. 2020

BioMed Research International

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Stomach ulcer is an endemic gastrointestinal disorder which constitutes a major public health problem all over the world. Stomach ulcer results when there is an imbalance between the protective factors (mucus and bicarbonate) and aggressive factors (acid and pepsin) in the stomach. Dried powdered leaves and stem of the phytomedicine Euphorbia hirta (E. hirta) (1000 g) was extracted with methanol using a soxhlet apparatus. The evaluation of the phytochemical constituents of E. hirta and acute toxicity (to ascertain the safety of using the phytomedicine over a short period of time) was carried out. The antiulcer and gastroprotective effects of crude extract of E. hirta combined with honey in rats were evaluated. The study model using 0.6 M HCl model of ulceration was used to evaluate the antiulcer and gastroprotective activities of the phytomedicine. The soxhlet extraction of E. hirta gave a yield of 54.5 g of crude extract (5.45%). Phytochemical screening of E. hirta showed that the extract contains alkaloids, tannins, saponins, glycosides, flavonoids, and unsaturated steroids. Acute toxicity studies showed that LD50 was greater than 5000 mg/kg. The study showed that the crude extract of E. hirta at 200 mg/kg when administered alone had 54% inhibition of ulceration while when administered together with honey increased to 94% inhibition of ulceration, but honey alone had 89.47% inhibition of ulceration. This implied that E. hirta when combined with honey had a synergistic effect and enhanced the inhibition of ulceration, and this could be seen by the protection of the gastric mucosa. The study of the phytomedicine E. hirta combined with honey revealed that the phytomedicine has antiulcer activities against 0.6 M HCl-induced gastric ulcer in rats. This therefore validates usage and claim by the Igbo people of the southeastern part of Nigeria that the phytomedicine of E. hirta combined with honey has good antiulcer potential.

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“…4). The bioactive constituents of E. hirta include flavonoids (quercetin and myrcetin), sterols, tannins, and triterpenoids (Attah et al, 2013;Onyeka et al, 2018;Salehi et al, 2019). The abundance of these bioactive substances makes them powerful scavengers.…”

Section: Resultsmentioning

confidence: 99%

A Comparison of Bioactive Constituents and in Vitro Antioxidant Potential of Asthma Weed (Euphorbia Hirta), With Those of Other Antiasthmatic Plants Growing in Tabuk Region, Saudi Arabia

Al-Mutairi¹

2019

Appl. Ecol. Env. Res.

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Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats

Cited by 10 publications

References 13 publications

Structural elucidation, mechanism of action, antibacterial proficiency and synergistic forte of purified Euphorbia hirta whole plant extract against multi-drug resistant otitis media infection

Structural elucidation, mechanism of action, antibacterial proficiency and synergistic forte of purified Euphorbia hirta whole plant extract against multi-drug resistant otitis media infection

Antiulcer Effects of Methanol Extract of Euphorbia hirta and Honey Combination in Rats

A Comparison of Bioactive Constituents and in Vitro Antioxidant Potential of Asthma Weed (Euphorbia Hirta), With Those of Other Antiasthmatic Plants Growing in Tabuk Region, Saudi Arabia

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