Toxicity effects of mycotoxins and autophagy: a mechanistic view

Ariafar, Saba; Harsin, Akram Oftadeh; fadaiie, Ahmad; Mahboobian, Mohammad Mehdi; Mohammadi, Mojdeh

doi:10.1080/15569543.2019.1711416

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Neurotoxicity Due To Ota Which Interferes With the Development Of Diseases Motor Disorder And Parkinson's Disease1

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2021

2022

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Cited by 2 publications

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“…Studies show that one of the most important functions of OTA is cellular destruction through autophagy (Shen et al, 2014). As noted, mitophagy is one of the most important and complex mechanisms of mitochondrial elimination (Ariafar et al, 2020). A study in 2014 noted activation of autophagy and mitophagy pathways by ochratoxin.…”

Section: Neurotoxicity Due To Ota Which Interferes With the Development Of Diseases Motor Disorder And Parkinson's Diseasementioning

confidence: 99%

Neurotoxicity mechanism of Ochratoxin A

Nourbakhsh

Tajbakhsh

2021

qas

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Mycotoxins, such as Ochratoxins, are widely distributed in nature and are common contaminants of human foodstuffs. Ochratoxins are a group of mycotoxins produced by a wide range of molds. Ochratoxin A (OTA), the most prominent member of this toxin family, is produced by various Aspergillus and Penicillium species. OTA is frequently found in foods such as cereals, oleaginous seeds, coffee, and meat products. This mycotoxin has been described as teratogenic, genotoxic, carcinogenic, and immunotoxic, and has been proven to be a potent neurotoxin. In the present study, the neurotoxicological perspective of OTA was reviewed and discussed. The main possible mechanisms of neurotoxicity are oxidative DNA, protein and lipid damage, and apoptosis. However, further studies are needed to conclude the exact neurotoxicity mechanism of OTA and find the approaches that reduce the neurotoxicity induced by OTA.

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Section: Neurotoxicity Due To Ota Which Interferes With the Development Of Diseases Motor Disorder And Parkinson's Diseasementioning

confidence: 99%