Toxicity effects of profenofos on embryonic and larval development of Zebrafish (Danio rerio)

Pamanji, R.; Yashwanth, B.; Bethu, Murali Satyanarayana; Leelavathi, Sadhu; Ravinder, K; Rao, J. Venkateswara

doi:10.1016/j.etap.2015.02.020

Cited by 64 publications

(25 citation statements)

References 27 publications

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“…For fish, the lipid normalized concentration ratio during embryo-to-adult transformation can be considered to assess the adult transfer potential of chemicals in oviparous organisms [ 19 ]. Zebrafish embryos are sensitive to environmental changes [ 20 ], easy to maintain and handle, and undergo rapid development [ 21 ]. Thus, it is important to investigate stereoselective toxicological properties of chiral PCBs in embryonic zebrafish.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Stereoselectivity in Embryo-Larvae (Danio rerio) Induced by Chiral PCB149 at the Bioconcentration and Gene Expression Levels

Chai

Cui

et al. 2016

PLoS ONE

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This paper was designed to study stereoselective enrichment and changes in gene expression when zebrafish (Danio rerio) embryo-larvae were exposed to racemic, (-)- or (+)- PCB149 (2,2’,3,4’,5’,6- hexachlorobiphenyl). Based on bioconcentration analysis, non-racemic enrichment was significantly observed after racemic exposure. No isomerization between the two isomers was found after (-)/(+)-PCB149 exposure. Furthermore, based on gene expression-data mining, CYPs genes (cyp2k6, cyp19a1b, and cyp2aa4) were differential genes after (+)-PCB149 exposure. No obvious differences of dysregulation of gene expression caused by racemic and (-)-PCB149, were observed in embryo-larvae. The above results suggested that (-)-PCB149 could be considered as the main factor causing the dysregulation of gene expression in embryo-larvae after racemic exposure; and (+)-PCB149 should be pursued apart from the racemate, when considering the toxicity of chiral PCB149. Thus, the information in our study could provide new insights to assess the environmental risk of chiral PCBs in aquatic systems.

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Section: Introductionmentioning

confidence: 99%

Exploration of Stereoselectivity in Embryo-Larvae (Danio rerio) Induced by Chiral PCB149 at the Bioconcentration and Gene Expression Levels

Chai

Cui

et al. 2016

PLoS ONE

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“…Similar observations have also been recorded in profenofos exposed animals by several earlier workers. [5][6][7][8][9] Curcumin treated profenofos exposed test group mice showed recovery in the histoarchitecture of renal cells. The inter-glomerular was reorganized almost near to normal mice.…”

Section: Resultsmentioning

confidence: 93%

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2016

IJPSR

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“…In addition, while the majority of previous studies have focussed on pre-natal and early post-natal exposure (Pamanji et al, 2015;Sun et al, 2014), our technique allows evaluation of neurotoxic effects on the visionmediated behaviour of adult zebrafish. Furthermore, it offers a platform for investigating a wide spectrum of neurodegenerative disorders including, among many others, Huntington's Disease, Alzheimer's Disease and amyotrophic lateral sclerosis, all of which have been modelled in zebrafish (Kabashi et al, 2011), but also appraising possible genetic or chemical therapies that could be used in the treatment of these conditions and so providing a platform for preclinical drug development.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

A colour preference technique to evaluate acrylamide-induced toxicity in zebrafish

Jia

Raghupathy

Albalawi

et al. 2017

Comparative Biochemistry and Physiology Part C: Toxicology &

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The zebrafish has become a commonly used vertebrate model for toxicity assessment, of particular relevance to the study of toxic effects on the visual system because of the structural similarities shared by zebrafish and human retinae. In this article we present a colour preference-based technique that, by assessing the functionality of photoreceptors, can be used to evaluate the effects of toxicity on behaviour. A digital camera was used to record the locomotor behaviour of individual zebrafish swimming in a water tank consisting of two compartments separated by an opaque perforated wall through which the fish could pass. The colour of the lighting in each compartment could be altered independently (producing distinct but connected environments of white, red or blue) to allow association of the zebrafish's swimming behaviour with its colour preference. The functionality of the photoreceptors was evaluated based on the ability of the zebrafish to sense the different colours and to swim between the compartments. The zebrafish tracking was carried out using our algorithm developed with MATLAB. We found that zebrafish preferred blue illumination to white, and white illumination to red. Acute treatment with acrylamide (2mM for 36 hours) resulted in a marked reduction in locomotion and a concomitant loss of colour-preferential swimming behaviour. Histopathological examination of acrylamide-treated zebrafish eyes showed that acrylamide exposure had caused retinal damage. The colour preference tracking techniquehas applications in the assessment of neurodegenerative disorders, as a method for preclinical appraisal of drug efficacy and for behavioural evaluation of toxicity.

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Toxicity effects of profenofos on embryonic and larval development of Zebrafish (Danio rerio)

Cited by 64 publications

References 27 publications

Exploration of Stereoselectivity in Embryo-Larvae (Danio rerio) Induced by Chiral PCB149 at the Bioconcentration and Gene Expression Levels

Exploration of Stereoselectivity in Embryo-Larvae (Danio rerio) Induced by Chiral PCB149 at the Bioconcentration and Gene Expression Levels

Untitled

A colour preference technique to evaluate acrylamide-induced toxicity in zebrafish

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