2012
DOI: 10.1166/jnn.2012.6667
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Toxicity Evaluation of Hydrophilic CdTe Quantum Dots and CdTe@SiO2 Nanoparticles in Mice

Abstract: Quantum dots have drawn tremendous attention in the field of in vitro and small animal in vivo fluorescence imaging in the last decade. However, concerns over the cytotoxicity of their heavy metal constituents have limited their use in clinical applications. Here, we report our comparative studies on the toxicities of quantum dots (QDs) and silica coated CdTe nanoparticles (NPs) to mice after intravenous injection. The blood cells analysis showed significant increased level of white blood cells (WBCs) in group… Show more

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Cited by 36 publications
(24 citation statements)
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“…From the past to present, a big concern accompanying the biomedical application of tellurium has been acute and subacute toxicity, which can be observed as a result of inhibition of glutathione peroxidase, bonding with sulfhydryl groups in different molecules, damage to nerves, the liver, and gastrointestinal cells, and disrupting of cholesterol metabolism pathways [165]. In contrast to the tellurium ion, tellurium NPs are gaining interest in biomedicine because they have lower toxicity than ionic tellurium, especially when they are used in combination with other compounds such as silica or cadmium in coated form [166].…”
Section: Tellurium Nanoparticlesmentioning
confidence: 99%
“…From the past to present, a big concern accompanying the biomedical application of tellurium has been acute and subacute toxicity, which can be observed as a result of inhibition of glutathione peroxidase, bonding with sulfhydryl groups in different molecules, damage to nerves, the liver, and gastrointestinal cells, and disrupting of cholesterol metabolism pathways [165]. In contrast to the tellurium ion, tellurium NPs are gaining interest in biomedicine because they have lower toxicity than ionic tellurium, especially when they are used in combination with other compounds such as silica or cadmium in coated form [166].…”
Section: Tellurium Nanoparticlesmentioning
confidence: 99%
“…With respect to toxicity, simple cadmium based QDs seem to be of rather limited applications. In the case of CdTe, it has different qualities than cadmium and tellurium taken separately and is less toxic than elemental cadmium and its the nephrotoxicity could be minimized, for instance, by silica coating [14]. Nevertheless, QDs of other chemical composition like InP/ZnS [15] and CuInS/ZnS [16] or even metalfree QDs become to be of interest [17].…”
Section: Introductionmentioning
confidence: 99%
“…This has led to them being classified as a powerful new class of bio-imaging tools [1][2][3][4][5][6][7][8]. Despite the desirability of using QDs as intense fluorescent nanoscale markers in biological applications, cytotoxicity is a serious constraint that limits potential uses [9][10][11]. QDs can be considered as being incubation of HCT-116 cells with the QDs over a wide range of concentrations (25 to 500 µg/ml).…”
Section: Introductionmentioning
confidence: 99%