Toxicity Evaluation of Nanomedicine

Panghal, Archna; Flora, S.J.S.

doi:10.1007/978-3-031-12398-6_19

Cited by 3 publications

(1 citation statement)

References 171 publications

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“…The 3D printing techniques commonly used in the development of personalized medicines are displayed in Figure 9 [255]. An interesting study reported the preparation of self-nanoemulsifying drug delivery systems (SNEDDS) in the form of 3D-printed tablets encapsulating dapagliflozin, an antidiabetic drug [256]. The combination of SNEDDS and the 3D printing technology approach provides an alternative to obtain self-nanoemulsifying solid dosage forms for poorly watersoluble drugs, and the ability to dispense tailored doses for diabetic patients (Figure 10).…”

Section: Personalized Medicine and Patient-specific Formulationsmentioning

confidence: 99%

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

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This study provides a brief discussion of the major nanopharmaceuticals formulations as well as the impact of nanotechnology on the future of pharmaceuticals. Effective and eco-friendly strategies of biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) are outlined. This paper discusses the need to use natural resources for the “green” design of new nanoformulations with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, and the preparation of nanomaterials must be carefully considered. Therefore, safety and long-term effects of pharmaceutical nanoformulations must not be overlooked. The testing of nanopharmaceuticals represents an essential point in their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent a valuable, bioinspired model for nanopharmaceutical testing that avoids using animals. Nanoformulations are critical in various fields, especially in pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations that allows improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields for cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. Here are the key points highlighting their importance. The significant challenges, opportunities, and future directions are mentioned in the final section.

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Section: Personalized Medicine and Patient-specific Formulationsmentioning

confidence: 99%

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

View full text Add to dashboard Cite

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Drug delivery methods for cancer immunotherapy

Pérez-Herrero

Lanier

Krishnan

et al. 2023

Drug Deliv. and Transl. Res.

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Despite the fact that numerous immunotherapy-based drugs have been approved by the FDA for the treatment of primary and metastatic tumors, only a small proportion of the population can benefit from them because of primary and acquired resistances. Moreover, the translation of immunotherapy from the bench to the clinical practice is being challenging because of the short half-lives of the involved molecules, the difficulties to accomplish their delivery to the target sites, and some serious adverse effects that are being associated with these approaches. The emergence of drug delivery vehicles in the field of immunotherapy is helping to overcome these difficulties and limitations and this review describes how, providing some illustrative examples. Moreover, this article provides an exhaustive review of the studies that have been published to date on the particular case of hematological cancers. Graphical Abstract (Created with BioRender)

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Nano-based approaches for the treatment of neuro-immunological disorders: a special emphasis on multiple sclerosis

Panghal,

Flora

2024

Discover Nano

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Multiple sclerosis (MS) is a neuroimmunological disorder which causes axonal damage, demyelination and paralysis. Although numerous therapeutics have been developed for the effective treatment of MS and a few have been approved in recent decades, complete remission and treatment of MS remain a matter of concern. Nanotechnology is a potential approach for manipulating the properties of materials at the molecular level to attain desired properties. This approach is effective in the treatment of several CNS disorders by enhancing drug delivery, bioavailability and efficacy. We have briefly discussed the neuroimmunological disorders with a particular emphasis on MS. We also explored nanoengineered drug delivery systems, describing several nano-formulations for the treatment of MS, challenges and future of nanotechnology.

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Toxicity Evaluation of Nanomedicine

Cited by 3 publications

References 171 publications

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Drug delivery methods for cancer immunotherapy

Nano-based approaches for the treatment of neuro-immunological disorders: a special emphasis on multiple sclerosis

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