Toxicity evaluation of silica nanoparticles for delivery applications

Tan, Yue; Yu, Dawei; Feng, Jiayao; You, Huimin; Bai, Yan; He, Jincan; Cao, Hua; Che, Qishi; Guo, Junpeng; Su, Zhixing

doi:10.1007/s13346-023-01312-z

Cited by 15 publications

(2 citation statements)

References 140 publications

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“…This is due to the tightly packed Si–O–Si structure within silica nanoparticles, which leads to slow degradation within the biological system and may result in their accumulation, causing tissue and organ damage and even systemic toxicity. 40–43 In recent years, research findings have indicated that silica nanoparticles can be combined with inorganic or organic components, further optimizing their tumor therapeutic and biodegradable capabilities and significantly advancing the development of TME-responsive degradable materials. 26,44–46 The outstanding degradability of silica nanoparticles not only enables efficient clearance and low toxicity but also allows precise control of drug release, thereby enhancing therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Zhang,

Tang,

Liu

et al. 2024

Nanoscale Horiz.

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Section: Introductionmentioning

confidence: 99%

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Zhang,

Tang,

Liu

et al. 2024

Nanoscale Horiz.

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“…Furthermore, they are used in the chemical industry as an ingredient in cosmetics, drugs, printer toner, varnishes, and food. Silicon dioxide nanoparticles are also more and more popular in both therapeutic and diagnostic applications of medicine [1,2]. Biomedical and biotechnological studies have focused on the use of silicon dioxide nanoparticles in therapies, and diagnostics has experienced much progress, including in cancer therapies, drug delivery, and enzyme deactivation [3].…”

Section: Introductionmentioning

confidence: 99%

Effect of Non-Modified as Well as Surface-Modified SiO2 Nanoparticles on Red Blood Cells, Biological and Model Membranes

Solarska-Ściuk,

Męczarska,

Jencova

et al. 2023

IJMS

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Nanoparticles are extremely promising components that are used in diagnostics and medical therapies. Among them, silica nanoparticles are ultrafine materials that, due to their unique physicochemical properties, have already been used in biomedicine, for instance, in cancer therapy. The aim of this study was to investigate the cytotoxicity of three types of nanoparticles (SiO2, SiO2-SH, and SiO2-COOH) in relation to red blood cells, as well as the impact of silicon dioxide nanoparticles on biological membranes and liposome models of membranes. The results obtained prove that hemolytic toxicity depends on the concentration of nanoparticles and the incubation period. Silica nanoparticles have a marginal impact on the changes in the osmotic resistance of erythrocytes, except for SiO2-COOH, which, similarly to SiO2 and SiO2-SH, changes the shape of erythrocytes from discocytes mainly towards echinocytes. What is more, nanosilica has an impact on the change in fluidity of biological and model membranes. The research gives a new view of the practical possibilities for the use of large-grain nanoparticles in biomedicine.

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Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

Zhang,

Zhou,

Tang

et al. 2024

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Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles in tumor diagnosis and treatment lie in their ability to target drug delivery, minimizing toxicity to normal tissues while enhancing therapeutic efficacy. Moreover, their responsiveness to both endogenous and exogenous stimuli opens up new possibilities for integrating multiple treatment modalities. This review scrutinizes the burgeoning utility of degradable silica nanoparticles in combination with chemotherapy and other treatment modalities. Commencing the elucidation of degradable silica synthesis and degradation mechanisms, emphasis is placed on the responsiveness of these materials to endogenous (e.g., pH, redox reactions, hypoxia, and enzymes) and exogenous stimuli (e.g., light and high‐intensity focused ultrasound). Moreover, this exploration delves into strategies harnessing degradable silica nanoparticles in chemotherapy alone, coupled with radiotherapy, photothermal therapy, photodynamic therapy, gas therapy, immunotherapy, starvation therapy, and chemodynamic therapy, elucidating multimodal synergies. Concluding with an assessment of advances, challenges, and constraints in oncology, despite hurdles, future investigations are anticipated to augment the role of degradable silica in cancer therapy. These insights can serve as a compass for devising more efficacious combined tumor treatment strategies.

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Toxicity evaluation of silica nanoparticles for delivery applications

Cited by 15 publications

References 140 publications

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Effect of Non-Modified as Well as Surface-Modified SiO2 Nanoparticles on Red Blood Cells, Biological and Model Membranes

Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

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