Toxicity evaluation of SPIONs on Danio rerio embryonic development

Samrot, Antony V.; Shobana, Nagarajan; Sathiyasree, Mahendran; Ramanathan, T.; Visvanathan, Sridevi; Mohanty, Basanta Kumar; Sabesan, Gokul Shankar; Dhiva, S.

doi:10.1016/j.matpr.2022.02.236

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…TMAT–functionalized gold nanoparticles of 1.3 nm size caused improper eye development, including alterations in pigmentation and neuronal damage, as well as behavioral problems [ 40 ]. Pericardial oedema, bent tail malformation, spinal curvature, non-inflated swim bladder, and yolk–sac oedema are some of the most commonly found defects in zebrafish embryos [ 41 , 42 ]. Silver nanoparticles and silver nitrate were investigated for toxicity against the freshwater fish Oreochromis mossambicus .…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Toxic Effect of Bauhinia purpurea Mediated Synthesized Silver Nanoparticles against In-vitro and In-vivo Models

Shobana

Prakash

Samrot

et al. 2022

Toxics

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Metal nanoparticles, such as gold nanoparticles, silver nanoparticles, etc., have many benefits and have been in use for a very long time. Nevertheless, a number of concerns have been raised about the environmental impact and the possibility of exposure to various living systems at the moment. Thus, in this study, silver nanoparticles were synthesized by using plant gum from Bauhinia purpurea and characterization was done using UV—Visible Spectroscopy, Scanning Electron Microscopy, X—ray Diffraction, etc. To determine the accumulation and toxic effects caused by the nanoparticles, Eudrilus eugeniae, Danio rerio, and their embryos were exposed to the synthesized silver nanoparticles and evaluated using microscopic observation, histology, and Inductively Coupled Plasma Optical Emission Spectrometry (ICP—OES).

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Section: Resultsmentioning

confidence: 99%

Evaluation of the Toxic Effect of Bauhinia purpurea Mediated Synthesized Silver Nanoparticles against In-vitro and In-vivo Models

Shobana

Prakash

Samrot

et al. 2022

Toxics

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“…Despite the advantages, biocompatibilities and toxicities of iron oxide nanoparticles raise real concerns [36,37]. When iron oxide nanoparticles were injected into a rat model, it was claimed that they created oxidative stress, lowering the antioxidant capability of the blood cells [38,39].…”

Section: Introductionmentioning

confidence: 99%

“…Various functional groups can be added to SPIONs to minimize the adverse biological effects [51]. Mice, Drosophila [46], earthworms [52], fishes [53][54][55][56], and even its embryos [36,57] are some of the model organisms previously reported for studying the toxicological effects of iron oxide nanoparticles. The objective of this investigation is to explore the histopathological impact of SPIONs in three different animal models: zebrafish (Danio rerio), earthworms (Eudrilus eugeniae), and Drosophila (Drosophila melanogaster).…”

Section: Introductionmentioning

confidence: 99%

Assessment on the Toxic Effects of Chemically Synthesized SPIONs against Model Organisms

Justin,

Samrot,

Shobana

et al. 2023

Journal of Nanomaterials

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The remarkable physicochemical properties of nanomaterials have attracted researchers due to the numerous applications in the field of chemistry, biology, and physics. Despite the various applications, superparamagnetic iron oxide nanoparticles (SPIONs) are harmful to living organisms and to the environment as they are released without any safety testing. In this study, SPIONs were synthesized and further characterized. The aim of the study was to examine the toxicity of synthesized SPIONs against animal models: Zebrafish—Danio rerio, Earthworm—Eudrilus eugeniae, and Drosophila—Drosophila melanogaster through histology using Hematoxylin–Eosin and Prussian Blue staining. The accumulation of SPIONs was further quantified by using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Through histology images, it was observed that the SPIONs had caused damages and a lower concentration of 0.001–0.002 μg/ml of metal accumulation was detected in the ICP-MS analysis.

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Evaluation of Heavy Metal Removal of Nanoparticles Based Adsorbent Using Danio rerio as Model

Samrot

Muthiah

Shree

et al. 2022

Toxics

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Nanoparticles are potential candidates for wastewater treatment especially for the removal of heavy metals due to their strong affinity. Many biopolymers are used as adsorbents and encapsulation of nanoparticle onto them can increase their efficiency. In this study, SPIONs, alginate, and SPIONs incorporated on alginate beads have been synthesized and characterized both microscopically and spectroscopically. These were then used for the removal of chromium metal and the percentage of removal was evaluated using a batch adsorption study. The percent removal of chromium using SPIONs, alginate and alginate–SPIONs beads were recorded to be 93%, 91% and 94%, respectively. The adsorption of chromium using SPIONs and alginate–SPIONs beads followed the Tempkin isotherm, whereas adsorption of chromium metal by alginate beads was found to be homogeneous in nature and followed the Langmuir isotherm with an R2 value of 0.9784. An in-vivo study using Danio rerio as a model organism was done to examine the toxicity and the removal efficiency of the samples. It was observed that chromium water treated with alginate–SPIONs beads, which were removed after water treatment showed less damage to the fishes when compared to SPIONs and alginate beads treated with chromium water where the SPIONs and alginate beads were not removed after the treatment period.

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Toxicity evaluation of SPIONs on Danio rerio embryonic development

Cited by 3 publications

References 27 publications

Evaluation of the Toxic Effect of Bauhinia purpurea Mediated Synthesized Silver Nanoparticles against In-vitro and In-vivo Models

Evaluation of the Toxic Effect of Bauhinia purpurea Mediated Synthesized Silver Nanoparticles against In-vitro and In-vivo Models

Assessment on the Toxic Effects of Chemically Synthesized SPIONs against Model Organisms

Evaluation of Heavy Metal Removal of Nanoparticles Based Adsorbent Using Danio rerio as Model

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