Toxicity impact of hydrogen peroxide on the fate of zebrafish and antibiotic resistant bacteria

Yoon, Hyojik; Kim, Hyun-Chul; Kim, Jongrack; You, Kwangtae; Cho, Yunchul; Kim, Sungpyo

doi:10.1016/j.jenvman.2021.114072

Cited by 6 publications

(6 citation statements)

References 59 publications

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“…Another study in common carp showed tissue-specific responses to H 2 O 2 exposure, affecting immune, inflammatory, autophagic, and DNA damage pathways at 0.2 mM to 1 mM H 2 O 2 concentrations 51 . Additionally, exposure to H 2 O 2 concentrations ranging from 0 to 100,000 nM impacted the locomotion and metabolism of both zebrafish larvae and adults 52 . It's noteworthy that this concentration range falls within the spectrum of H 2 O 2 levels found in aquatic environments such as lake, river, rain, estuary, and open ocean, ranging from 0.004 μM to 199 μM 9 .…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress induced by hydrogen peroxide disrupts zebrafish visual development by altering apoptosis, antioxidant and estrogen related genes

Saputra,

Kishida,

2024

Sci Rep

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Hydrogen peroxide is considered deleterious molecule that cause cellular damage integrity and function. Its key redox signaling molecule in oxidative stress and exerts toxicity on a wide range of organisms. Thus, to understand whether oxidative stress alters visual development, zebrafish embryos were exposed to H2O2 at concentration of 0.02 to 62.5 mM for 7 days. Eye to body length ratio (EBR) and apoptosis in retina at 48 hpf, and optomotor response (OMR) at 7 dpf were all measured. To investigate whether hydrogen peroxide-induced effects were mediated by oxidative stress, embryos were co-incubated with the antioxidant, glutathione (GSH) at 50 μM. Results revealed that concentrations of H2O2 at or above 0.1 mM induced developmental toxicity, leading to increased mortality and hatching delay. Furthermore, exposure to 0.1 mM H2O2 decreased EBR at 48 hpf and impaired OMR visual behavior at 7 dpf. Additionally, exposure increased the area of apoptotic cells in the retina at 48 hpf. The addition of GSH reversed the effects of H2O2, suggesting the involvement of oxidative stress. H2O2 decreased the expression of eye development-related genes, pax6α and pax6β. The expression of apoptosis-related genes, tp53, casp3 and bax, significantly increased, while bcl2α expression decreased. Antioxidant-related genes sod1, cat and gpx1a showed decreased expression. Expression levels of estrogen receptors (ERs) (esr1, esr2α, and esr2β) and ovarian and brain aromatase genes (cyp19a1a and cyp19a1b, respectively) were also significantly reduced. Interestingly, co-incubation of GSH effectivity reversed the impact of H2O2 on most parameters. Overall, these results demonstrate that H2O2 induces adverse effects on visual development via oxidative stress, which leads to alter apoptosis, diminished antioxidant defenses and reduced estrogen production.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress induced by hydrogen peroxide disrupts zebrafish visual development by altering apoptosis, antioxidant and estrogen related genes

Saputra,

Kishida,

2024

Sci Rep

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“…Zebrafish that have begun to distinguish colors have a characteristic of preferring a short-wavelength region (blue) rather than a long-wavelength region (yellow), which has been proven experimentally by previous work [ 17 ].…”

Section: Methodsmentioning

confidence: 90%

The Impact Evaluation of Acid Mine Drainage on Zebrafish (Danio rerio) and Water Fleas (Daphnia magna) in the Vicinity of the Geum River Basin in Korea

Yoon

2022

IJERPH

Self Cite

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Heavy metals, such as copper, lead, and cadmium, carried by acid mine drainage are pollutants of the aquatic ecosystem, posing a significant health risk to the water resource for humans. Environmental technologies to reduce metal contamination are applied for post-mining prevention and improvement. Despite detailed pollution management, water contaminated by heavy metals still flows into the natural water system. This study investigated the impact of drainage discharged from abandoned mines near the major river in South Korea on aquatic organisms. The toxicity of the field water showed a more significant effect than observed through the experiment for each heavy-metal concentration. Various toxic substances coexisted in the field water around the mine, such that the overall toxic intensity was high even when the concentration of each heavy metal was low. As a result, the inhibition of activity of aquatic organisms was observed at low individual concentrations, and further investigation on the effect of long-term exposure to trace amounts of heavy metals is required.

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“…Interestingly, the impact of low concentrations of H 2 O 2 on zebrafish behaviors has also been of scientific interest. Yoon H. et al [ 93 ] studied changes in the behavior of zebrafish after short-term exposure to low concentrations of H 2 O 2 . It has been shown that the safe H 2 O 2 concentration for both larval and adult zebrafish is 10 nM.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that the safe H 2 O 2 concentration for both larval and adult zebrafish is 10 nM. Meanwhile, 100 nM H 2 O 2 affected color preference in 5 dpf larval zebrafish, as well as decreased average velocity, average acceleration, active time, and total distance moved in larvae and adult fish [ 93 ].…”

Section: Discussionmentioning

confidence: 99%

A Short Review of the Toxicity of Dentifrices—Zebrafish Model as a Useful Tool in Ecotoxicological Studies

Stachurski,

Świątkowski,

Ciszewski

et al. 2023

IJMS

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This review aims to summarize the literature data regarding the effects of different toothpaste compounds in the zebrafish model. Danio rerio provides an insight into the mechanisms of the ecotoxicity of chemicals as well as an assessment of their fate in the environment to determine long-term environmental impact. The regular use of adequate toothpaste with safe active ingredients possessing anti-bacterial, anti-inflammatory, anti-oxidant, and regenerative properties is one of the most effective strategies for oral healthcare. In addition to water, a typical toothpaste consists of a variety of components, among which three are of predominant importance, i.e., abrasive substances, fluoride, and detergents. These ingredients provide healthy teeth, but their environmental impact on living organisms are often not well-known. Each of them can influence a higher level of organization: subcellular, cellular, tissue, organ, individual, and population. Therefore, it is very important that the properties of a chemical are detected before it is released into the environment to minimize damage. An important part of a chemical risk assessment is the estimation of the ecotoxicity of a compound. The zebrafish model has unique advantages in environmental ecotoxicity research and has been used to study vertebrate developmental biology. Among others, the advantages of this model include its external, visually accessible development, which allows for providing many experimental manipulations. The zebrafish has a significant genetic similarity with other vertebrates. Nevertheless, translating findings from zebrafish studies to human risk assessment requires careful consideration of these differences.

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Toxicity impact of hydrogen peroxide on the fate of zebrafish and antibiotic resistant bacteria

Cited by 6 publications

References 59 publications

Oxidative stress induced by hydrogen peroxide disrupts zebrafish visual development by altering apoptosis, antioxidant and estrogen related genes

Oxidative stress induced by hydrogen peroxide disrupts zebrafish visual development by altering apoptosis, antioxidant and estrogen related genes

The Impact Evaluation of Acid Mine Drainage on Zebrafish (Danio rerio) and Water Fleas (Daphnia magna) in the Vicinity of the Geum River Basin in Korea

A Short Review of the Toxicity of Dentifrices—Zebrafish Model as a Useful Tool in Ecotoxicological Studies

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