Toxicity in combined therapies for tumours treatments: a lesson from BAG3 in the TME?

Turco, Maria Caterina; Marzullo, Liberato; Marco, Margot De; Laurenzi, Vincenzo De; D’Amico, Maria Francesca; Turco, Maria Caterina

doi:10.3389/fimmu.2023.1241543

Cited by 2 publications

(1 citation statement)

References 17 publications

(32 reference statements)

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“…Ex vivo studies on mouse tissues showed that combo treatments were able to promote an immunostimulatory microenvironment along with a significant reduction of cancer fibrosis [105][106][107]. Further refinements and developments of the anti-BAG3 mAb-based therapies could hopefully contribute additional evidence of efficacy and safety of combined treatments and could allow tailoring and diversify the protocols for other solid tumors [108].…”

Section: Communications Breakdown Operated By Monoclonal Antibodiesmentioning

confidence: 99%

Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

Cammarota,

Falco,

Basile

et al. 2023

Cancers

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Pancreatic Ductal Adenocarcinoma (PDAC) is a ravaging disease with a poor prognosis, requiring a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggest a shift in focus towards the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer-secreted proteins in the complex TME tumor-stroma crosstalk, shedding lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies.

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Section: Communications Breakdown Operated By Monoclonal Antibodiesmentioning

confidence: 99%

Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

Cammarota,

Falco,

Basile

et al. 2023

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

Pancreatic Cancer- Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

Cammarota,

Falco,

Basile

et al. 2023

Preprint

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Pancreatic ductal adenocarcinoma (PDAC) is a ravaging disease whose poor prognosis requires a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggested to rather focus on the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer secreted proteins in the complex TME tumor-stroma crosstalk, to sched lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies.

show abstract

Toxicity in combined therapies for tumours treatments: a lesson from BAG3 in the TME?

Cited by 2 publications

References 17 publications

Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

Pancreatic Cancer- Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

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