Toxicity of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats after single oral administration

Occurrence of Two Different Types of Glutathione S-Transferase Placental Form-Positive Hepatocytes after a Single Administration of 2,3,7,8-Tetrabromodibenzo-p-dioxin in Rats

“…This finding might extend the previously reported findings 11,14,15,37) of the enhanced TBDD hepatotoxicity of female rats to higher susceptibility of female rats to the formation of GST-P-positive liver foci than males. Lucier et al 38) demonstrated using the two-stage hepatocarcinogenesis model that the number of GST-P-positive foci were greater in intact female rats receiving a single ip injection of DEN followed by repeated oral administration of TCDD at a dose equivalent to 100 ng/kg/d for 30 wk than in ovariectomized rats receiving DEN and TCDD.…”

“…Except for a medical case report 10) on laboratory exposure of a chemist to TBDD, there are few medical case reports and epidemiological studies or animal toxicology studies of PBDD/PBDF available for human health risk assessments. Experimental toxicology studies have revealed that TBDD caused systemic, hematological, hepatic, teratogenic and myelogenic toxicities [11][12][13][14][15] .…”

Systemic and myelotoxic effects of single administration of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats

“…The same administering methods and dose levels of TBDD as those used by Ivens et al (12) were employed in this study. The test substance was predissolved in degassed toluene and added to corn oil.…”

“…Single oral and intraperitoneal administrations of TBDD were reported to induce teratogenic effects in mice (10) and thymic atrophy, body weight loss and induction of hepatic microsomal enzymes in immature male rats (11), respectively. Furthermore, by studying overall evaluation of hematological, hepatic and systemic toxicities and target organ doses after single administration of TBDD by gavage to male and female rats, Ivens et al (12) reported that most effects and toxic symptoms of TBDD seemed to be comparable to those seen after TCDD administration. However, myelotoxic effects of TBDD have not been reported so far, although bone marrow and its hematopoietic stem cells have been shown to be sensitive targets for treatment in rats and mice with TCDD (13)(14)(15)(16)(17)(18)(19).…”

Toxicological Studies in Albino Rats Maintained on Fish Smoked with Firewood and Waste Tyre Materials

“…And since these compounds are involved in plasma proteins synthesis, hepatocytes accumulation of dioxins may change the peripheral blood status and influence the biochemical response to an inflammatory reaction. However, the nonsignificant change in cholesterol in the supplemented groups could be attributed to the antioxidant (flavonoids) and hypocholestrolemic (saponins) properties of the supplements, which may have given some chemoprotection [33,34].…”