Toxicity of a moniliformin-producing strain of fusarium moniliforme var. subglutinans isolated from maize

Kriek, N.P.J.; Marasas, Walter F. O.; Steyn, Pieter S.; Rensburg, S.J. Van; Steyn, M.

doi:10.1016/0015-6264(77)90073-6

Cited by 139 publications

(102 citation statements)

References 17 publications

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“…fusaproliferin, enniatins, and beauvericin) from Fusarium strains has been shown to be 20-30°C. 20,22,23,[26][27][28] Consistent with these data, results from this study indicate that an optimum temperature for the maximal production of neoN-methylsansalvamide was about 25°C.…”

Section: Effects Of Culture Conditions On Response Variablessupporting

confidence: 80%

Optimization of culture conditions of Fusarium solani for the production of neoN-methylsansalvamide

Lee

Phat

Nam

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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The aim of this study was to optimize the culture conditions of Fusarium solani KCCM90040 on cereal grain for the production of neoN-methylsansalvamide, a novel low-molecular-weight cyclic pentadepsipeptide exhibiting cytotoxic and multidrug resistance reversal effects. From the analysis of variance results using response surface methodology, temperature, initial moisture content, and growth time were shown to be important parameters for the production of neoN-methylsansalvamide on cereal grain. A model was established in the present study to describe the relationship between environmental conditions and the production of neoN-methylsansalvamide on rice, the selected cereal grain. The optimal culture conditions were determined at 25.79°C with the initial moisture content of 40.79%, and 16.19 days of growth time. This report will give important information concerning the optimization of environmental conditions using statistic methodology for the production of a new cyclic pentadepsipeptide from fungi.Key words: cyclic pentadepsipeptides; Fusarium solani; environmental conditions; response surface methodology Various reviews of peptides from fungi have revealed that Fusarium strains found in fungi-infected plants produce several cyclic depsipeptides such as beauvericin, 1) enniatins, 2,3) zygosporamide, 4) and neosansalvamide analogs 5,6) via the non-ribosomal peptide synthesis system. 7,8) These cyclic depsipetides exhibit numerous pharmaceutical benefits such as cytotoxic, 9,10) antifungal, 11) and antibiotic 1) effects as well as calcium channel antagonism.12) Another cytotoxic cyclic pentadepsipeptides, sansalvamide analogs, were produced by Fusarium strains. 13,14) Sansalvamide A was first reported from the marine micro-organism Halodule wrightii, 14)This N-methylated sansalvamide exhibited in vitro cytotoxicity in a National Cancer Institute human tumor cell line screen (EC 50 = 8.3 μmol).14) Sansalvamide showed cytototoxic potency against HCT116 (colon carcinoma), COLO205 (colon), and SK-MEL-2 (melanoma) cancer cell lines with EC 50 values of 9.8, 3.5, and 5.9 μg/mL, respectively. 13) Sansalvamide and its analogs, which were produced by organic synthesis, caused marked time-and concentration-dependent inhibition of DNA synthesis and cell proliferation of human pancreatic cancer cell lines. [15][16][17] Furthermore, sansalvamide and its analogs showed a strong cytotoxic effect against multidrug resistance (MDR) human colon cancer cell lines.18) These anticancer effects of sansalvamide analogs can be attributed to their inhibition of topoisomerase I, and their cytotoxicity may be mediated by this mechanism.17,19) Sansalvamide analogs exhibited cytotoxic activity against human cancer cell lines, suggesting that they could be valuable therapeutic agents. 17,18) Our research group isolated several Fusarium strains producing different cyclic depsipeptides including enniatins H, I, and MK1688 with beauvericin. 20) Interestingly, one isolate (Fusarium solani KCCM90040) produced a novel cyclic pentadepsipeptide, n...

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Section: Effects Of Culture Conditions On Response Variablessupporting

confidence: 80%

Optimization of culture conditions of Fusarium solani for the production of neoN-methylsansalvamide

Lee

Phat

Nam

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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“…subglutinans (Fusarium sacchari var. subglutinans) 2 = Fusarium subglutinans (see this) Hussein et al, 1991;Kriek et al, 1977;Lew et al, 1996;Logrieco et al, 1993;Marasas et al, 1986;Rabie et al, 1982 Fusarium napiforme Marasas et al, 1991;Schütt et al, 1998 Fotso et al, 2002;Schütt et al, 1998 Marasas et al, 1988;Schütt et al, 1998 …”

Section: Fungal Species Referencesmentioning

confidence: 99%

“…Schütt et al, 1998 Fusarium pseudocircinatum Fotso et al, 2002;Schütt et al, 1998Fusarium pseudonygamai Fotso et al, 2002Schütt et al, 1998 Hussein et al, 1991;Kriek et al, 1977;Marasas et al, 1986;Lew et al, 1996;Logrieco et al, 1993;Rabie et al, 1982;Schütt et al, 1998 Fusarium temperatum Scauflaire et al, 2011;Sewram et al, Ballester, A.R., Marcet-Houben, M., Levin, E., Sela, N., Selma-Lazaro, C., Carmona, L., Wisniewski, M., Droby, S., Gonzales-Candelas, L. …”

Section: Fusarium Pseudoanthophilumunclassified

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

Frisvad

2018

WMJ

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A very large number of filamentous fungi has been reported to produce the small lactone mycotoxins patulin, penicillic acid and moniliformin. Among the 167 reported fungal producers of patulin, only production by 29 species could be confirmed. Patulin is produced by 3 Aspergillus species, 3 Paecilomyces species, 22 Penicillium species from 7 sections of Penicillium, and one Xylaria species. Among 101 reported producers of penicillic acid, 48 species could produce this mycotoxin. Penicillic acid is produced by 23 species in section Aspergillus subgenus Circumdati section Circumdati, by Malbranchea aurantiaca and by 24 Penicillium species from 9 sections in Penicillium and one species that does not actually belong to Penicillium (P. megasporum). Among 40 reported producers of moniliformin, five species have been regarded as doubtful producers of this mycotoxin or are now regarded as taxonomic synonyms. Moniliformin is produced by 34 Fusarium species and one Penicillium species. All the accepted producers of patulin, penicillic acid and moniliformin were revised according to the new one fungus – one name nomenclatural system, and the most recently accepted taxonomy of the species.

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“…This toxin causes intoxication, and the lesions include intestinal hemorrhage, muscle weakness, breathing difficulty, cyanosis, coma and death [73]. However, in studies in barnyard fowls and rodents using subacute and chronic dosages, its effect was on the heart.…”

Section: Moniliforminmentioning

confidence: 99%

Mycotoxins that Affect the Human Cardiovascular System

Carvajal-Moreno¹

2015

Pharm Anal Acta

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Mycotoxins are toxic secondary metabolites produced by fungi in the field or during storage; these fungi are mainly saprophytic molds growing on foodstuffs or animal feeds. These molds produce chemical compounds of low molecular weight that are not detected by antigens and hence are insidious poisons with no obvious symptoms. Since 1960, mycotoxins have been considered responsible for diseases and death in domestic animals and humans. Mycotoxicoses, the diseases caused by mycotoxins, have been responsible for major epidemics in humans and domestic animals since agriculture was developed. Each of these diseases is caused by specific molds that produce one or more potent toxins, usually in one specific type of commodity or feed. Among the main mycotoxigenic fungi are the genera Aspergillus spp., Penicillium spp. and Fusarium spp.The symptoms caused by mycotoxins can be acute or chronic, depending on the type of toxin and the dose. The symptoms of acute mycotoxicoses include liver and kidney damage, attacks on the central nervous system, skin disorders, hormonal effects, miscarriage, hemorrhage, vomiting, diarrhea and many others. Mycotoxins are eaten in trace quantities in the daily diet; some, such as aflatoxins, can accumulate, whereas others are quickly eliminated. Examples of chronic mycotoxicoses include Reye syndrome, Kwashiorkor, and cancers that develop in experimental animals or humans long after the mycotoxin is eaten. In the present review, we will describe some mycotoxins that cause circulatory problems, vein breakage, hemorrhage, and heart failure. The structures, physicochemical properties [7], biosynthesis [8], production conditions and occurrence of aflatoxins are also well known [9,10]. One important property of aflatoxins is that they form links to DNA, RNA and proteins [11,12], and they accumulate over time as adducts of AFB1-formamidopyrimidine (AFB1-FAPY) [13] and AFB1-lysine albumin [14], which are active carcinogens. Mycotoxins that Affect the Human Cardiovascular SystemMagdaAflatoxins, the most powerful mycotoxins, were discovered in the early 1960s with the outbreak of turkey "X" disease in England and high incidences of liver disease in ducklings in Kenya and hatcheryreared trout in the United States; the causes of all these problems were aflatoxins [15]. Aflatoxins are present in numerous foods, such as cereals, spices [16], oilseeds [17], and dry fruits. After these foods are consumed, the aflatoxins pass into milk, [18,19], all dairy products, eggs [20] and meat [21] derivatives. Aflatoxins are considered unavoidable toxins [22]. Biological control measures include lactic acid bacterial fermentation, which is known to render cereal-based foods and beverages safe [23], and the use of aluminosilicates, glucomannans and optimal storage conditions to prevent fungal growth.Aflatoxin intake is related to kwashiorkor [24] and Reye syndrome [25], and aflatoxins induce liver damage in undernourished individuals [26]. Aflatoxins are classified as Group I carcinogens in humans [27]; the...

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Toxicity of a moniliformin-producing strain of fusarium moniliforme var. subglutinans isolated from maize

Cited by 139 publications

References 17 publications

Optimization of culture conditions of Fusarium solani for the production of neoN-methylsansalvamide

Optimization of culture conditions of Fusarium solani for the production of neoN-methylsansalvamide

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

Mycotoxins that Affect the Human Cardiovascular System

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