Toxicity of Alumina Nanoparticles in The Immune System of Mice

Li, Huan; Huang, Tao; Wang, Yanhong; Pan, Baolong; Zhang, Ling; Zhang, Qinli; Niu, Qiao

doi:10.2217/nnm-2020-0009

Cited by 31 publications

(20 citation statements)

References 58 publications

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“…Additionally, previous studies have also shown that Al 2 O 3 NPs can cause pro‐inflammatory reactions, which may be a risk of cardiovascular disease (Oesterling et al, 2008). Recently, it has been documented that Al 2 O 3 NPs can accumulate in mice spleen, and Al 2 O 3 NPs exposure caused cytokine level changes in the spleen, thymus, and serum, besides causing damage to immune organs and dysfunction of immune cells, leading to abnormal immune‐related cytokine expression (Li et al, 2020). Likewise, using male Wistar rat model, it was found that exposure to Al 2 O 3 NPs and/or HClg aerosols for 4 h (unique exposures) or 4 h a day for 4 days (iterative exposures), primarily manifests the toxicological effects of the mixture, whereas Al 2 O 3 NPs' presence in the aerosols also seems to play essential role in driving toxicity (Bourgois et al, 2020).…”

Section: Nano‐metal Oxidesmentioning

confidence: 99%

Research progress on the carcinogenicity of metal nanomaterials

Liu

Kong

2021

J of Applied Toxicology

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With the rapid development of nanotechnology, new nanomaterials with enormous potentials continue to emerge, especially metal nanomaterials. Metal nanomaterials possess the characteristics of metals and nanomaterials, so they are widely used in many fields. But at the same time, whether the use or release of metal nan4omaterials into the environment is toxic to human beings and animals has now attained widespread attention at home and abroad. Currently, it is an indisputable fact that cancer ranks among the top causes of death among residents worldwide. The properties of causing DNA damage and mutations possessed by these metal nanomaterials make them unpredictable influences in the body, subsequently leading to genotoxicity and carcinogenicity. Due to the increasing evidence of their roles in carcinogenicity, this article reviews the toxicological and carcinogenic effects of metal nanomaterials, including nano‐metal elements (nickel nanoparticles, silver nanoparticles, and cobalt nanoparticles) and nano‐metal oxides (titanium dioxide nanoparticles, silica nanoparticles, zinc oxide nanoparticles, and alumina nanoparticles). This article provides a reference for the researchers and policymakers to use metal nanomaterials rationally in modern industries and biomedicine.

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Section: Nano‐metal Oxidesmentioning

confidence: 99%

Research progress on the carcinogenicity of metal nanomaterials

Liu

Kong

2021

J of Applied Toxicology

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“…The spleen and thymus IFN-γ content in the AlNP-exposed mice was significantly higher. Serum IL-4 levels were also decreased, and this decline could affect the autoimmune response mediated by Th1 cells [37].…”

Section: Al and The Immune Systemmentioning

confidence: 99%

Potential Role of Trace Elements (Al, Cu, Zn, and Se) in Multiple Sclerosis Physiopathology

Hesamian

Eskandari

2020

Neuroimmunomodulation

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Multiple sclerosis (MS) is an unpredictable disease of the central nervous system. The cause of MS is not known completely, and pathology is specified by involved demyelinated areas in the white and gray matter of the brain and spinal cord. Inflammation and peripheral tolerance breakdown due to Treg cell defects and/or effector cell resistance are present at all stages of the disease. Several invading peripheral immune cells are included in the process of the disease such as macrophages, CD8+ T cells, CD4+ T cells, B cells, and plasma cells. Trace elements are known as elements found in soil, plants, and living organisms in small quantities. Some of them (e.g., Al, Cu, Zn, Mn, and Se) are essential for the body’s functions like catalysts in enzyme systems, energy metabolism, etc. Al toxicity and Cu, Zn, and Se toxicity and deficiency can affect the immune system and following neuron inflammation and degeneration. These processes may result in MS pathology. Of course, factors such as lifestyle, environment, and industrialization can affect levels of trace elements in the human body.

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“…Alumina (aluminum oxide) nanoparticles (AlNPs) account for about 20% of the global nanoparticle market (Sengul and Asmatulu 2020). They have multiple uses in cosmetics, medicines, electronics, aerospace, chemical engineering, food contact materials, catalysts, ceramics and rubber (Li et al 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, because the cell surface is negatively charged and AlNPs are positively charged, these particles are drawn to the interior of cells through electrostatic interactions (Liu et al 2020a). This in turn produces many toxic effects including hematological changes (De et al 2020), genotoxicity (Zhang et al 2017), testicular toxicity (De et al 2020), carcinogenicity (Dey et al 2008) immunotoxicity (Li et al 2020), hepatotoxicity, nephrotoxicity (Morsy et al 2016) and pulmonary toxicity (Yun et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

Abou‐Zeid

Elkhadrawey

Anis

et al. 2021

Preprint

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Alumina nanoparticles (AlNPs) are widely used causing neurobehavioral impairment in intoxicated animals and human. Sesamol (SML) emerged as a natural phytochemical with potent antioxidant and anti-inflammatory properties. However, no study has directly tested the potential of SML to protect against AlNPs induced detrimental effects on the brain. AlNPs (100 mg/kg) were orally administered to `rats by gavage with or without oral sesamol (100 mg/kg) for 28 days. In AlNPs-intoxicated group, brain AChE activity was elevated. The concentrations of MDA and 8-OHdG were increased suggesting lipid peroxidation and oxidative DNA damage. GSH depletion with inhibited activities of CAT and SOD were demonstrated. Serum levels of IL-1β and IL-6 were elevated. The expressions of GST, TNF-α and caspase-3 genes in brain were upregulated. Histopathologically, AlNPs induced hemorrhages, edema, neuronal necrosis and/ or apoptosis in medulla oblongata. The cerebellum showed loss of Purkinje cells and the cerebrum showed perivascular edema, neuronal degeneration, necrosis, and neuronal apoptosis. However, concomitant administration of SML with AlNPs significantly ameliorated the toxic effects on the brain, reflecting antioxidant, anti-inflammatory and anti-apoptotic effects of SML. Considering these results, sesamol could be promising phytochemical with neuroprotective activity against AlNPs-induced neurotoxicity.

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Toxicity of Alumina Nanoparticles in The Immune System of Mice

Cited by 31 publications

References 58 publications

Research progress on the carcinogenicity of metal nanomaterials

Research progress on the carcinogenicity of metal nanomaterials

Potential Role of Trace Elements (Al, Cu, Zn, and Se) in Multiple Sclerosis Physiopathology

Neuroprotective Effect of Sesamol Against Aluminum Nanoparticles induced Toxicity in Rats

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