Toxicity of binary mixtures of oil fractions to sea urchin embryos

Rial, Diego; Vázquez, José Antonio; Menduíña, Araceli; García, Ana M. García; González, M.P.; Mirón, Jesús; Murado, M.A.

doi:10.1016/j.jhazmat.2013.09.059

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…The validity of the Weibull equation proposed has been again revealed. Habitually used for the modelling of dose-response curves, animal growths, and chemical and enzymatic reactions without mechanistical basis [ 7 , 23 ], that mathematical model has been recently applied to the description of enzyme proteolysis of fish cartilages [ 24 ] and squid pen [ 25 ] with excellent outcomes. Two parameters ( H m and v m ) from equation [ 5 ] were selected as responses (dependent variables) to assess the effect of pH and T on proteolysis.…”

Section: Resultsmentioning

confidence: 99%

Production of Fish Protein Hydrolysates from Scyliorhinus canicula Discards with Antihypertensive and Antioxidant Activities by Enzymatic Hydrolysis and Mathematical Optimization Using Response Surface Methodology

et al. 2017

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Fish discards are of major concern in new EU policies. Alternatives for the management of the new biomass that has to be landed is compulsory. The production of bioactive compounds from fish protein hydrolysates (FPH) has been explored in recent years. However, the viability of Scyliorhinus canicula discards, which might account for up to 90–100% of captures in mixed trawler, gillnet, and longline industrial fisheries, to produce FPH from the muscle with bioactivities has still not been studied in terms of the optimization of the experimental conditions to enhance its production. The effect of pH and temperature on the hydrolysis of the S. canicula muscle was mediated by three commercial proteases using response surface methodology. Temperatures of 64.6 °C and 60.8 °C and pHs of 9.40 and 8.90 were established as the best hydrolysis conditions for Alcalase and Esperase, respectively. Optimization of the best conditions for the maximization of antihypertensive and antioxidant activities was performed. Higher Angiotensin-converting enzyme (ACE) activity was found with Esperase. The pH optimum and temperature optimum for antioxidants were 55 °C/pH8.0 for ABTS/DPPH-Esperase, 63.1 °C/pH9.0 for DPPH-Alcalase, and 55 °C/pH9.0 for ABTS-Alcalase. No hydrolysis was detected when using Protamex.

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Section: Resultsmentioning

confidence: 99%

Production of Fish Protein Hydrolysates from Scyliorhinus canicula Discards with Antihypertensive and Antioxidant Activities by Enzymatic Hydrolysis and Mathematical Optimization Using Response Surface Methodology

et al. 2017

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“…However, on a soil concentration basis, antagonism was observed, likely due to decreased bioavailability from preferential partitioning to nonaqueous phases in soil (Cermak et al ). Concentration addition was also a better model fit when mixtures of oil fractions were tested on sea urchin embryos (Rial et al ). The equivalence of concentration addition and independent action models in our system highlights the limitations of these models, as has been observed by others (van Gestel et al ; Backhaus and Faust ; Backhaus et al ).…”

Section: Discussionmentioning

confidence: 99%

“…Within certain categories of carbon chain length, aliphatic petroleum hydrocarbons act via the same toxic mechanism of action, which is nonpolar narcosis; thus, petroleum hydrocarbon mixture toxicity theoretically follows concentration addition (van Gestel et al ). Rial et al () found that concentration addition was a better option than independent action to explain the binary toxicity of crude oil water‐soluble fractions, with no synergistic or antagonistic interactions. Studies on the toxic effects of single petroleum hydrocarbon distillates to earthworms found concentration addition mixture toxicity on an organism tissue concentration basis but antagonism on a soil concentration basis, with authors suggesting that the discrepancy is due to reduced bioavailability from the presence of nonaqueous phase liquid (Energy Services Group International ; Cermak et al ).…”

Section: Introductionmentioning

confidence: 99%

Petroleum hydrocarbon mixture toxicity and a trait‐based approach to soil invertebrate species for site‐specific risk assessments

Gainer

Cousins

Hogan

et al. 2018

Enviro Toxic and Chemistry

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Although petroleum hydrocarbons released to the environment typically occur as mixtures, petroleum hydrocarbon remediation guidelines often reflect individual substance toxicity. It is well documented that groups of aliphatic petroleum hydrocarbons act via the same mechanism of action (nonpolar narcosis) and, theoretically, concentration addition mixture toxicity principles apply. To assess this theory, 10 standardized acute and chronic soil invertebrate toxicity tests on a range of organisms (Eisenia fetida, Lumbricus terrestris, Enchytraeus crypticus, Folsomia candida, Oppia nitens, and Hypoaspis aculeifer) were conducted with a refined petroleum hydrocarbon binary mixture. Reference models for concentration addition and independent action were applied to the mixture toxicity data with consideration of synergism, antagonism, and dose level toxicity. Both concentration addition and independent action, without further interactions, provided the best fit with observed response to the mixture. Individual fraction effective concentration values were predicted from optimized, fitted reference models. Concentration addition provided a better estimate than independent action of individual fraction effective concentrations based on comparison with available literature and species trends observed in toxic responses to the mixture. Interspecies differences in standardized laboratory soil invertebrate species responses to petroleum hydrocarbon-contaminated soil was reflected in unique traits. Diets that included soil, large body size, permeable cuticle, low lipid content, lack of ability to molt, and no maternal transfer were traits linked to a sensitive survival response to petroleum hydrocarbon-contaminated soil in laboratory tests. Traits linked to sensitive reproduction response in organisms tested were long life span and small clutch size. By deriving single-fraction toxicity endpoints considerate of mixtures, we can reduce the resources and time required to conduct site-specific risk assessments for the protection of a soil organism's exposure pathway. Environ Toxicol Chem 2018;37:2222-2234. © 2018 SETAC.

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“…It occupies the littoral/sub-littoral zone and inhabits rocky areas along the Tunisian coast (Gharred et al 2015a). It has been frequently used as a bioindicator of early biological effects of pollutants including trace metals (Saco-Alvarez et al 2010), pesticides (Pesando et al 2004), and hydrocarbons (Rial et al 2013). Several arguments justified their use as a preferred animal model in toxicology including their sedentary, benthic lifestyle, availability all the year, wide geographical distribution, well-known biology, and high bioaccumulation of chemical contaminants (Danis et al 2005;Pétinay et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the individual and mixture toxicity of cadmium, copper and oxytetracycline, on the embryo-larval development of the sea urchin Paracentrotus lividus

Gharred

Jebali

Belgacem

et al. 2016

Environ Sci Pollut Res

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Multiple pollutions by trace metals and pharmaceuticals have become one of the most important problems in marine coastal areas because of its excessive toxicity on organisms living in this area. This study aimed to assess the individual and mixture toxicity of Cu, Cd, and oxytetracycline frequently existing in the contaminated marine areas and the embryo-larval development of the sea urchin Paracentrotus lividus. The individual contamination of the spermatozoid for 1 h with the increasing concentrations of Cd, Cu, and OTC decreases the fertility rate and increases larvae anomalies in the order Cu > Cd > OTC. Moreover, the normal larva frequency and the length of spicules were more sensitive than the fertilization rate and normal gastrula frequency endpoints. The mixture toxicity assessed by multiple experimental designs showed clearly that concentrations of Cd, Cu, and OTC superior to 338 μg/L, 0.56 μg/L, and 0.83 mg/L, respectively, cause significant larva malformations.

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Toxicity of binary mixtures of oil fractions to sea urchin embryos

Cited by 8 publications

References 36 publications

Production of Fish Protein Hydrolysates from Scyliorhinus canicula Discards with Antihypertensive and Antioxidant Activities by Enzymatic Hydrolysis and Mathematical Optimization Using Response Surface Methodology

Production of Fish Protein Hydrolysates from Scyliorhinus canicula Discards with Antihypertensive and Antioxidant Activities by Enzymatic Hydrolysis and Mathematical Optimization Using Response Surface Methodology

Petroleum hydrocarbon mixture toxicity and a trait‐based approach to soil invertebrate species for site‐specific risk assessments

Assessment of the individual and mixture toxicity of cadmium, copper and oxytetracycline, on the embryo-larval development of the sea urchin Paracentrotus lividus

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