Toxicity of binary mixtures of Al<sub>2</sub>O<sub>3</sub> and ZnO nanoparticles toward fibroblast and bronchial epithelium cells

Köerich, Jéssica Schveitzer; Nogueira, Diego José; Vaz, Vitor Pereira; Simioni, Carmen; Silva, Marlon Luiz Neves da; Ouriques, Luciane Cristina; Vicentini, Denice Schulz; Matias, William Gerson

doi:10.1080/15287394.2020.1761496

Cited by 17 publications

(9 citation statements)

References 89 publications

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“…Based on the observed median effect concentration (EC50) values, the toxicity values for AgNP and glyphosate, individually and in a binary mixture, were evaluated considering different toxic units of 0, 0.25, 0.5, 1, 1.5, 1.75, and 2, according to methodology previously described in the literature (Köerich et al 2020) with minor modifications. The validation of the results, in relation to the interaction of the mixtures, was carried out using the Abbott method (Abbott 1925) developed for the evaluation of pesticides and, in recent years, utilized for NPs (Gatidou and Thomaidis 2007; Liu et al 2019).…”

Section: Methodsmentioning

confidence: 99%

Multigenerational Toxic Effects on Daphnia magna Induced by Silver Nanoparticles and Glyphosate Mixture

Silva

Nogueira

Köerich

et al. 2021

Enviro Toxic and Chemistry

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Multigenerational toxicological effects of a binary mixture of silver nanoparticles (AgNPs) with glyphosate were identified in Daphnia magna using acute and chronic toxicity tests. Acute toxicity interactions were analyzed with the Abbott method. In the chronic tests, the survival, growth, reproduction, and age at first brood were evaluated for the parents and the exposed (F1E) and non-exposed (F1NE) descendants. The scales tested for binary mixture, at the acute level, presented antagonistic and additive interactions, possibly associated with the complexation of the AgNPs by glyphosate. Multigenerational chronic effects related to the parameters, reproduction, and age at first brood were observed in the descendants tested with the individual compounds, with no recovery for F1E and F1NE. In organisms exposed to binary mixture, there was a delay in the age at first brood and also a significant change in the reproduction parameter, with a strong reduction for the parents, F1E, and F1NE, indicating a higher toxicity than the compounds tested individually. Although the results for acute interactions between AgNP and glyphosate did not provide clear evidence, multigenerational chronic binary mixture trials have resulted in unexpected toxicity compared with individual treatments, increasing the concerns associated with this co-exposure in other scenarios. Therefore, the interaction of binary mixture with the organisms merits further investigation and the results reported in the present study will be useful in this regard.

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Section: Methodsmentioning

confidence: 99%

Multigenerational Toxic Effects on Daphnia magna Induced by Silver Nanoparticles and Glyphosate Mixture

Silva

Nogueira

Köerich

et al. 2021

Enviro Toxic and Chemistry

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“…The sequence of events associated with the induction of cell death in S. cerevisiae by NiO NPs was described (Sousa et al 2019c ). Other studies also indicated a cell dead apoptotic pathway in human cell lines exposed to CuO (Siddiqui et al 2013 ), NiO (Siddiqui et al 2012 ), ZnO (Keerthana and Kumar 2020 ), or binary mixtures of Al 2 O 3 and ZnO NPs (Koerich et al 2020 ).…”

Section: Yeast Responses To Mox Nps Stressmentioning

confidence: 97%

Harmful effects of metal(loid) oxide nanoparticles

Soares

2021

Appl Microbiol Biotechnol

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“…It clearly appeared that the toxicity from multiple nanoparticles exposure was poorly investigated. Indeed, only 10% of the studies investigated the joint toxicity upon exposure to two types of nanoparticles (Feng et al, 2017;Guo et al, 2021;He et al, 2020;Köerich et al, 2020;Lee et al, 2021;Rosário et al, 2020). This overlooked type of mixture can however provide critical information.…”

Section: A Literature Review On the Joint Toxicity Of Nanoparticles And Co-contaminantsmentioning

confidence: 99%

Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

Forest

2021

NanoImpact

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Air pollution is considered as a major public health issue worldwide. It consists of a complex mixture of pollutants including nanoparticles to which we are increasingly exposed to due to the dramatic development of the nanotechnologies and their incidental or intentional release in the environment. Consequently, some concerns have raised about the combined toxicity of air particulates and other air pollutants on human health. However, the interactions between the contaminants and their resulting combined toxicity are often overlooked. Indeed, the biological effects triggered by nanoparticles are usually assessed focusing on individual nanoparticles, while their interaction with co-contaminants can deeply impact, either positively or negatively, their biodistribution, fate in the organism and toxicological profile (additive, synergistic or antagonistic responses). This paper presents a bibliographic review on the combined toxicity of nanoparticles and co-pollutants and discusses the underlying mechanisms. It also highlights the scarcity of data in the current literature, arguing for an urgent need to take into account the mixture effects to be more representative of real-life conditions for a better and accurate human health risk assessment and management.

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Toxicity of binary mixtures of Al₂O₃ and ZnO nanoparticles toward fibroblast and bronchial epithelium cells

Cited by 17 publications

References 89 publications

Multigenerational Toxic Effects on Daphnia magna Induced by Silver Nanoparticles and Glyphosate Mixture

Multigenerational Toxic Effects on Daphnia magna Induced by Silver Nanoparticles and Glyphosate Mixture

Harmful effects of metal(loid) oxide nanoparticles

Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

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Toxicity of binary mixtures of Al2O3 and ZnO nanoparticles toward fibroblast and bronchial epithelium cells

Cited by 17 publications

References 89 publications

Multigenerational Toxic Effects on Daphnia magna Induced by Silver Nanoparticles and Glyphosate Mixture

Multigenerational Toxic Effects on Daphnia magna Induced by Silver Nanoparticles and Glyphosate Mixture

Harmful effects of metal(loid) oxide nanoparticles

Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

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Product

Resources

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Toxicity of binary mixtures of Al₂O₃ and ZnO nanoparticles toward fibroblast and bronchial epithelium cells