Toxicity of carbon-based nanomaterials: Reviewing recent reports in medical and biological systems

Madannejad, Rasoul; Shoaie, Nahid; Jahanpeyma, Fatemeh; Darvishi, Mohammad Hasan; Azimzadeh, Mostafa; Javadi, Hamidreza

doi:10.1016/j.cbi.2019.04.036

Cited by 181 publications

(113 citation statements)

References 231 publications

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“…The shape of carbon derived nanomaterials is a relevant characteristic influencing their interaction with biological molecules and organisms. However, other physicochemical features of carbon derived nanomaterials such as the chemical composition, size, stability, functionalization, charge, porosity and hydrophobicity/hydrophilicity, agglomeration or aggregation, also affect their reactivity 49 , making thus difficult to predict their toxicological potential in a particular organism by only considering their morphology.…”

Section: Resultsmentioning

confidence: 99%

Toxicological response of the model fungus Saccharomyces cerevisiae to different concentrations of commercial graphene nanoplatelets

Suárez-Diez

Porras

Laguna-Teno

et al. 2020

Sci Rep

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Graphene nanomaterials have attracted a great interest during the last years for different applications, but their possible impact on different biological systems remains unclear. Here, an assessment to understand the toxicity of commercial polycarboxylate functionalized graphene nanoplatelets (Gn) on the unicellular fungal model Saccharomyces cerevisiae was performed. While cell proliferation was not negatively affected even in the presence of 800 mg L −1 of the nanomaterial for 24 hours, oxidative stress was induced at a lower concentration (160 mg L −1), after short exposure periods (2 and 4 hours). no DnA damage was observed under a comet assay analysis under the studied conditions. in addition, to pinpoint the molecular mechanisms behind the early oxidative damage induced by Gn and to identify possible toxicity pathways, the transcriptome of S. cerevisiae exposed to 160 and 800 mg L −1 of Gn was studied. Both GN concentrations induced expression changes in a common group of genes (337), many of them related to the fungal response to reduce the nanoparticles toxicity and to maintain cell homeostasis. Also, a high number of genes were only differentially expressed in the GN800 condition (3254), indicating that high GN concentrations can induce severe changes in the physiological state of the yeast.

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Section: Resultsmentioning

confidence: 99%

Toxicological response of the model fungus Saccharomyces cerevisiae to different concentrations of commercial graphene nanoplatelets

Suárez-Diez

Porras

Laguna-Teno

et al. 2020

Sci Rep

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“…Other representatives of GBMs include fullerenes and CNTs. Fullerene is produced by spherically wrapping 2D GR sheets into 0D closed formations [1,30]. CNTs are formed by graphenic layers containing carbon atoms in sp 2 -hybridized state, which are rolled up into a hollow, cylindrical arrangement [31][32][33].…”

Section: Graphene-based Materialsmentioning

confidence: 99%

“…GR-and GO-based materials can be characterized according to the procedure proposed by Wick et al [35]. The basic qualities which should be carefully observed are the number of layers (thickness), lateral size distribution, and C/O ratio, as is represented in Figure 6 [16,30,35]. The lateral size of GR flakes is one of the major factors influencing GR properties, because differences in size and geometry encourage a change in the ratio between the edge and the bulky structures, resulting in limited space in specific dimensions and a consequent change in mechanical and electrical properties [37].…”

Section: Graphene-based Materialsmentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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“…At the same time, many studies point to a toxicity of nanomaterials. 37,38 In the present work, we increased the amount of capsules on the biosensor surface from 17.5 × 10 4 (used in work 36 ) up to 15 × 10 6 and, thus, succeeded in changing the biosensor's main parameters, sensitivity (which changed from 0.05 up to 0.12 μA/mM) and detection range (which changed from 1.0 -25.0 to 0.1 -10.0 mM), as well as in decreasing the glucose detection limit (from 1.0 mM down to 0.1 mM) without using nanotubes. Although the sensitivity of the biosensor with nanotubes is still higher (0.30 μA/mM) and the glucose detection lower limit is lower (0.05 mM), the biosensors presented in this work can find practical applications.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Electrochemical Sensors Based on Enzyme Immobilized into Polyelectrolyte Microcapsules and into Chitosan Gel

et al. 2019

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The characteristics of an electrochemical biosensor based on a Prussian-blue screen-printed electrode containing glucose oxidase incorporated into polyelectrolyte microcapsules (PMC) are considered. PMC with the embedded enzyme were formed using sodium polystyrene sulfonate and poly(allylamine hydrochloride). The characteristics were compared with those of the enzyme immobilized in chitosan gel. We assessed the dependences of biosensor signals on the composition of the buffer solution, on the glucose concentration; the operational and long-term stabilities. The enzyme immobilized in PMC proved to be more sensitive to buffer molarity at a maximum within 35-40 mM. The apparent Michaelis constants were 1.5 and 4.1 mM at the immobilization in, respectively, chitosan and PMC. The developed biosensors were used to assay commercial juices. The biosensors' data on the glucose contents were shown to have a high correlation with the standard spectrophotometric assay (0.92-0.95%), which implies a possible application of the fabricated biosensors in foodstuff analysis.

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Toxicity of carbon-based nanomaterials: Reviewing recent reports in medical and biological systems

Cited by 181 publications

References 231 publications

Toxicological response of the model fungus Saccharomyces cerevisiae to different concentrations of commercial graphene nanoplatelets

Toxicological response of the model fungus Saccharomyces cerevisiae to different concentrations of commercial graphene nanoplatelets

Graphenic Materials for Biomedical Applications

Comparative Study of Electrochemical Sensors Based on Enzyme Immobilized into Polyelectrolyte Microcapsules and into Chitosan Gel

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