Toxicity of coumarins in plant defense against pathogens

Zaynab, Madiha; Khan, Jallat; Al-Yahyai, Rashid; Sadder, Monther; Li, Shuangfei

doi:10.1016/j.toxicon.2024.108118

Toxicon

2024

DOI: 10.1016/j.toxicon.2024.108118

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Toxicity of coumarins in plant defense against pathogens

Madiha Zaynab,

Jallat Khan,

Rashid Al-Yahyai

et al.

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2024

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Cited by 2 publications

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Selective Enzymatic C−H‐Oxyfunctionalization for the Efficient Synthesis of Grevillic Acid

Cziegler,

Baumert,

Badenhorst

et al. 2024

Adv Synth Catal

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In this study, a selective C‐H oxyfunctionalization using an unspecific peroxygenase (UPO) enabled an efficient biosynthetic route for the synthesis of grevillic acid (GA), a natural antioxidant. The route commenced with the release of o‐coumaric acid (oCA) from trans‐2‐coumaric acid glucoside (trans‐CAG) using commercially available ꞵ‐glucosidase from almonds. In addition, a cis‐to‐trans photoisomerization of cis‐CAG was implemented to increase the synthetic access of oCA. The key step, the para‐hydroxylation relative to the existing hydroxyl group of oCA, was accomplished by an UPO with full conversion and 93% isolated yield. Despite its name, the UPO turned out to exhibit excellent regioselectivity in this C‐H functionalization, requiring only H2O2 as a cosubstrate.

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Selective Enzymatic C−H‐Oxyfunctionalization for the Efficient Synthesis of Grevillic Acid

Cziegler,

Baumert,

Badenhorst

et al. 2024

Adv Synth Catal

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The genus Fraxinus L. (Oleaceae): A review of botany, traditional and modern applications, phytochemistry, and bioactivity

Guo,

Zhang,

Gao

et al. 2024

Phytochemistry

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Toxicity of coumarins in plant defense against pathogens

Cited by 2 publications

References 58 publications

Selective Enzymatic C−H‐Oxyfunctionalization for the Efficient Synthesis of Grevillic Acid

Selective Enzymatic C−H‐Oxyfunctionalization for the Efficient Synthesis of Grevillic Acid

The genus Fraxinus L. (Oleaceae): A review of botany, traditional and modern applications, phytochemistry, and bioactivity

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