Toxicity of Diflubenzuron and Temephos on Freshwater Fishes: Ecotoxicological Assays with Oreochromis niloticus and Hyphessobrycon eques

Abe, Flavia Renata; Machado, Ângela Aparecida; Coleone, Ana Carla; Cruz, Claudinei da; Machado-Neto, J. G.

doi:10.1007/s11270-019-4128-7

Cited by 18 publications

(9 citation statements)

References 34 publications

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“…Diflubenzurone controls the population of adult mosquitoes and larvae by directly interfering with chitin synthesis and preventing the seedling of insects and other organisms with chitin skeleton, such as crustaceans. [72][73][74][75] Temephos is a pesticide that mainly acts through inhibition of the activity of the enzyme acetylcholinesterase in the nervous system, which metabolizes the neurotransmitter acetylcholine. 74 The half maximal effective concentration (EC 50 ) values at 48-h post-treatment with temephos and diflubenzurone were 0.15 (0.1-0.2) μg L −1 and 0.06 (0.03-0.1) μg L −1 , respectively, when tested in a non-target organism using the Daphnia magna toxicity model.…”

Section: Discussionmentioning

confidence: 99%

“…aegypti , at the doses of 0.02 to 0.25 and 1 mg L −1 , respectively. Diflubenzurone controls the population of adult mosquitoes and larvae by directly interfering with chitin synthesis and preventing the seedling of insects and other organisms with chitin skeleton, such as crustaceans 72–75 . Temephos is a pesticide that mainly acts through inhibition of the activity of the enzyme acetylcholinesterase in the nervous system, which metabolizes the neurotransmitter acetylcholine 74 …”

Section: Discussionmentioning

confidence: 99%

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Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Targanski

Sousa

Pádua

et al. 2020

Pest Management Science

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BACKGROUND: The expansion of Aedes aegypti (Diptera: Culicidae) population has increased the number of cases of arboviruses, in part due to the inefficiency and toxicity of the chemical control methods available to control this vector. We synthesized 19 chalcone derivatives and examined their activity against Ae. aegypti larvae in order to select larvicidal compounds that are non-toxic to other organisms. RESULTS: Seven chalcone derivatives (3a, 3e, 3f, 6a, 6c, 6d, and 6f) had lethal concentrations of substituted chalcones capable of killing 50% (LC 50) values lower than 100 mg mL −1 at 24 h post-treatment, which is the dose that the World Health Organization recommends for the selection of promising larvicides. The type of substituent added to (E)-1,3-diphenylprop-2-en-1-one (3a) markedly affected the larvicidal activity. Addition of chlorine, bromine and methoxy groups to the aromatic rings reduced the larvicidal activity, while replacement of the Bring (phenyl) by a furan ring significantly increased the larvicidal activity. The furan-chalcone (E)-3-(4-bromophenyl)-1-(furan-2-yl)prop-2-en-1-one (6c) killed Ae. aegypti larvae (LC 50 = 6.66 mg mL −1 ; LC 90 = 9.97 mg mL −1) more effectively than the non-substituted chalcone (3a) (LC 50 = 14.43 mg mL −1 ; LC 90 = 20.96 mg mL −1), and was not toxic to the insect Galleria mellonella, to the protozoan Tetrahymena pyriformis, and to the algae Chorella vulgaris. CONCLUSIONS: The substitution pattern of chalcones influenced their larvicidal activity. In the set of compounds tested, (E)-3-(4-bromophenyl)-1-(furan-2-yl)prop-2-en-1-one (6c) was the most effective larvicide against Ae. aegypti, with no clear signs of toxicity to other animal models. Its mechanism of action and effectiveness under field conditions remain to be determined.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Targanski

Sousa

Pádua

et al. 2020

Pest Management Science

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“…Diflubenzurom, amplamente utilizado em substituição ao temefós devido à resistência deste, apresentou alta toxicidade para Daphnia magna 57 . Ambos, diflubenzuron e temefós, foram considerados tóxicos para os peixes Oreochromis niloticus e Hyphessobrycon eques 58 . Outro estudo observou que temefós e diflubenzurom reduziram populações de insetos aquáticos 59 .…”

Section: Estudos Ecotoxicológicos Dos Ingredientes Ativos Presentes E...unclassified

Registro e perfil ecotoxicológico de produtos para controle de Aedes aegypti

Magalhães

Silva²,

Espindola

2021

Visa em Debate

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Introdução: Arboviroses transmitidas pelo Aedes aegypti têm grande relevância para a saúde pública, sendo o controle químico do vetor uma importante estratégia de mitigação. Entretanto, o uso intensivo de pesticidas está associado a seleção de insetos resistentes e impacto ambiental. Por isso, é essencial desenvolver e regulamentar novos produtos, eficazes e sustentáveis. Objetivo: Descrever os requisitos para regulação de inseticidas e repelentes no Brasil, à luz de orientações internacionais. Comparar os ativos regulamentados no país com os disponíveis nos Estados Unidos (EUA) e União Europeia (UE). Por fim, realizar um levantamento de estudos ecotoxicológicos dos ativos empregados no controle vetorial. Método: Revisão narrativa de instrumentos regulatórios nacionais e internacionais, literatura científica, consulta a agências regulatórias e ao ECOTOX Knowledgebase. Resultados: As normas brasileiras trazem exigências consoantes com as internacionais. Todos os ativos disponíveis nos EUA têm monografia aprovada pela Anvisa; já a UE mostrou-se mais restritiva. Há menos repelentes tópicos disponíveis no Brasil e na UE, comparando-se com EUA. Muitos dos inseticidas aprovados para controle vetorial representam risco para organismos não alvo. Ainda assim, não identificamos quaisquer estudos para alguns dos produtos no banco de dados pesquisado. Conclusões: A UE mostrou-se a agência mais restritiva com relação ao registro de inseticidas. Existe a necessidade de guias com orientações específicas sobre o desenvolvimento de produtos inovadores para o controle do mosquito, bem como de ferramentas de busca com maior transparência na página da agência brasileira. Finalmente, esta revisão reitera a importância de análises ecotoxicológicas mais abrangentes para os produtos em questão, considerando seu potencial dano ambiental.

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“…Moreover, temephos incurs serious negative side effects. It causes irreversible damage to non-target aquatic predators and humans, thus limiting its use [8][9] . In this glum context, many researchers have urgently developed alternative strategies that are safer for humans and the environment 6 .…”

Section: Introductionmentioning

confidence: 99%

Ovicidal toxicity of plant essential oils and their major constituents against two mosquito vectors and their non-target aquatic predators

Moungthipmalai

Puwanard

Aungtikun

et al. 2022

Preprint

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Plant essential oil (EO) is a natural alternative to synthetic chemical insecticides for mosquito control. EOs from Citrus aurantium L., Cymbopogon citratus (Stapf.), and Cinnamomum verum (J. Presl.) were selected for topical assay of their ovicidal activity against Aedes aegypti L. and Aedes albopictus (Skuse). Their efficacy was compared to that of 1% (w/w) temephos. In addition, their non-toxicity against aquatic mosquito predators, Poecilia latipinna and Poecilia reticulate, was tested. Found by GC-MS analysis, the major constituent of C. verum EO was trans- cinnamaldehyde, of C. aurantium EO was d-limonene, and of C. citratus EO was geranial. Both C. verum EO and trans-cinnamaldehyde at a high concentration (30,000 ppm) exhibited high ovicidal activity against Ae. aegypti and Ae. albopictus eggs after 48 h of incubation with an inhibition rate of 91.0–93.0% for C. verum EO and 96.7–95.2% for trans-cinnamaldehyde. The combination of C. verum EO + geranial exhibited the strongest synergistic inhibition activity (100%) against the two mosquito vectors and was five times more effective than temephos. Moreover, they were not toxic to the non-target fishes. As a safe ovicidal agent for mosquito egg control, the combination of C. verum EO + geranial has excellent potential.

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Toxicity of Diflubenzuron and Temephos on Freshwater Fishes: Ecotoxicological Assays with Oreochromis niloticus and Hyphessobrycon eques

Cited by 18 publications

References 34 publications

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Larvicidal activity of substituted chalcones against Aedes aegypti (Diptera: Culicidae) and non‐target organisms

Registro e perfil ecotoxicológico de produtos para controle de Aedes aegypti

Ovicidal toxicity of plant essential oils and their major constituents against two mosquito vectors and their non-target aquatic predators

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