Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: Implications for environmental risk assessment

González-Pleiter, Miguel; Gonzalo, Soledad; Rodea-Palomares, Ismael; Leganés, Francisco; Rosal, Roberto; Boltes, Karina; Marco, E.; Fernández-Piñas, Francisca

doi:10.1016/j.watres.2013.01.020

Cited by 644 publications

(250 citation statements)

References 75 publications

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“…Antibiotics such as SMX and TRI find their way into the environment mainly through effluent of wastewater treatment plants, and are considered "pseudo-persistent" due to their continued release into the environment (González-Pleiter et al 2013). In laboratory settings, mussel sub-cellular endpoints such as genotoxic and immunotoxic metrics have responded to a suite of pharmaceuticals, including antibiotics (Gagné et al 2006, Lacaze et al 2015.…”

Section: Discussionmentioning

confidence: 99%

“…With the ever-fluctuating cocktails of low levels of pharmaceuticals in waterways, systematic mixture studies are needed to parse out unknown synergisms. González-Pleiter et al (2013) found from their tests using antibiotic mixtures on freshwater organisms, "it can be concluded that certain specific combinations may pose a potential ecological risk for aquatic ecosystems with the present environmentally measured concentrations." Current lack of management action on behalf of governing bodies in the form of preventative measures to lessen impacts of pharmaceutical contaminants may be due to the fact that the concentrations in which these drugs are detected are often a small fraction of typical prescribed therapeutic doses for humans and animals.…”

Section: Chapter 1: Introductionmentioning

confidence: 99%

“…Aquatic studies of pharmaceutical effects on microalgae have focused on acute toxicity of freshwater microalgae, with most experimental tests completed within 96 hours (Halling-Sørensen 2000, Cleuvers 2003, Eguchi et al 2004, El-Bassat et al 2012, González-Pleiter et al 2013). There is a lack of chronic effects studies using environmentally-relevant concentrations of drugs.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Antibiotic Mixtures across Marine Intertidal Trophic Levels: Examining Environmentally-Relevant Contaminant Concentrations

Teixeira¹

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Approximately 48% of Americans use prescription drugs within each 30-day period, and there are signs this trend is increasing. Although many studies track pharmaceuticals' fates in contaminating waterways, only fairly recent efforts have examined the potential impacts of these drugs on non-target organisms. The antibiotics sulfamethoxazole and trimethoprim, often prescribed together to treat bacterial infections, have been detected worldwide in marine and estuarine environments at concentrations up to 700-800 ng/L each. Toxic effects of these drugs have been identified in freshwater organisms, with synergistic effects observed in short-term studies of mixtures of the two; however, little research has examined possible sub-lethal and longer-term effects of antibiotics in environmentally-relevant mixture concentrations on marine organisms. I examined the long-term effects of mixtures of these two antibiotics in species of a marine system: marine microalgal species, and marine mussels, to determine whether the levels currently present in waterways affect organism health and reproduction.Microalgal species may be among the most sensitive organisms to pharmaceutical contaminants based on ecotoxicity research. I exposed three species of marine microalgae (Isochrysis galbana, Chaetoceros neogracile, and Nannochloropsis oculata) to environmentally-relevant mixtures of sulfamethoxazole and trimethoprim and examined their three-week growth rates. I found that for each species, the antibiotic treatments significantly suppressed algal growth. Specifically, I found that sulfamethoxazole was a driving factor in suppression of C. neogracile and I. galbana growth, while N. oculata responded more sensitively to a broader range of treatment mixture levels, which also ii included trimethoprim-only treatment groups and mixtures. These results on marine microalgae address critical data gaps, and identify the impacts of pharmaceuticals on marine primary producers, which could have direct ecosystem implications to higher trophic levels.Antibiotic pharmaceuticals can also affect marine mussel health, based on previous study of sub-cellular endpoints. I hypothesized that the important benthic foundational species, the Mytilus californianus mussel, would be significantly impacted by long-term 12-week exposure to environmentally-relevant concentrations and mixtures of sulfamethoxazole and trimethoprim. Specifically, I measured growth rate, feeding rate, condition index, and gonando-somatic index as indicators of whole-organism and reproductive health. Sulfamethoxazole concentrations, in particular, and trimethoprim to a lesser extent, suppressed mussel growth and significantly affected condition index and gonandosomatic index over time. The results of this study offer an understanding of how an intertidal system responds to chronic presence of antibiotic mixtures in the water, and a more complete picture of the environmental consequences of pharmaceutical contaminants released into marine ecosystems at ever-growing rates.iii ACKNO...

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Section: Discussionmentioning

confidence: 99%

Section: Chapter 1: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Antibiotic Mixtures across Marine Intertidal Trophic Levels: Examining Environmentally-Relevant Contaminant Concentrations

Teixeira¹

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“…Though the environmental concentrations detected were in ng/L to low μg/L, still they can pose risk to some of the sensitive, non-targeted species (Migliore. L, 1993 ;Halling-Sorensen et al, 2000;Wollenberger et al, 2000;Halling-Sorensen et al, 2002;Kummerer, 2009;Gonzalez-Pleiter et al, 2013). Some of the antibiotics may have same mechanism of action due to their common physico-chemical behavior; especially antibiotics come from same chemical family; in such cases organisms will be at increased risk as a result of additive effects (Kummerer, 2009;Gonzalez-Pleiter et al, 2013).…”

Section: Identification Of Acetyl-sulfamethoxazolementioning

confidence: 99%

“…In acute toxicity studies, assessment of whether an antibiotic pose risk to organisms in the environment is done by comparing PEC or MEC with its PNEC to organism, expressed as RQ. Where PNEC represents the worstcase no effect concentration of antibiotic, predicted or derived from acute toxicity data (EC 50 values) by applying a standard assessment factor of 1000 (EC, 2003;Hernando et al, 2006;Gonzalez-Pleiter et al, 2013). Assessment factor was applied to account for intra-and inter-species variability in sensitivity.…”

Section: Toxicity Studiesmentioning

confidence: 99%

Assessment of the Occurrence and Potential Risks of Antibiotics and their Metabolites in South Florida Waters Using Liquid Chromatography Tandem Mass Spectrometry

Panditi¹

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This dissertation, written by Venkata Reddy Panditi, and entitled Assessment of the occurrence and potential risks of antibiotics and their metabolites in South Florida waters using liquid chromatography tandem mass spectrometry, having been approved in respect to style and intellectual content, is referred to you for judgment.We have read this dissertation and recommend that it be approved. _______________________________________Rudolf Jaffe Finally, all the antibiotics detected in reclaimed and surface waters were investigated to assess the potential risk to the aquatic organisms. The surface water antibiotic concentrations that represented the real time exposure conditions revealed that the macrolide antibiotics, erythromycin, clarithromycin and tylosin along with quinolone antibiotic, ciprofloxacin were suspected to induce high toxicity to aquatic biota.Preliminary results showing that, among the antibiotic groups tested, macrolides posed the highest ecological threat, and therefore, they may need to be further evaluated with, long-term exposure studies considering bioaccumulation factors and more number of species selected. Overall, the occurrence of antibiotics in aquatic environment is posing an ecological health concern.

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Effects of Organic Pollutants on Photosynthesis

Tomar

Singh

Jajoo

2019

Photosynthesis, Productivity and Environmental Stress

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Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: Implications for environmental risk assessment

Cited by 644 publications

References 75 publications

Effects of Antibiotic Mixtures across Marine Intertidal Trophic Levels: Examining Environmentally-Relevant Contaminant Concentrations

Effects of Antibiotic Mixtures across Marine Intertidal Trophic Levels: Examining Environmentally-Relevant Contaminant Concentrations

Assessment of the Occurrence and Potential Risks of Antibiotics and their Metabolites in South Florida Waters Using Liquid Chromatography Tandem Mass Spectrometry

Effects of Organic Pollutants on Photosynthesis

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