Toxicity of Heavy Metal in River Water Alters the Physiological and Immunological Functions in Tilapia,  &lt;i&gt;Oreochromis niloticus&lt;i&gt;&lt;/i&gt;&lt;/i&gt;

Hossain, Zakir; Hossain, Md. Saddam; Ema, Noore Safa; Omri, Abdelwahab

doi:10.2139/ssrn.3884868

Cited by 2 publications

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“…Natural water ecosystems are disturbed by multiple pollutant mixtures and other factors that effect changes in organisms' surroundings and their health (Ossana et al, 2016;Hossain et al, 2021, Ogunwole et al, 2021. Pollution with trace metals is still a widespread problem worldwide and is especially increasing in anthropogenically active regions (Raesi et al, 2015;Elia et al, 2017;Hasanein et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…The evaluation of different biochemical parameters has been performed on a variety of sh species in order to detect metabolic changes due to exposure to different xenobiotics under laboratory (Alak et al, 2019) and in situ (Fazio et al, 2018) conditions. The activity of several antioxidant and detoxifying enzymes were assessed in different sh species after treatment with trace metals -Oreochromis niloticus (Atli et al, 2006;Hossain et al, 2021), O. aureus and Tilapia zillii (Hasanein et al, 2022), Clarias gariepinus (Hasanein et al, 2022), Rutilus rutilus caspicus (Raesi et al, 2015) and Oncorhynchus mykiss (Elia et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Acetylcholinesterase (AChE) is a key enzyme in the nervous system and catalyses the degradation of acetylcholine into acetate and choline (Correia et al, 2019). Its activity is widely used as a biomarker of neurotoxicity in various aquatic organisms, including and sh species (Sevcikova et al, 2011;Souid et al, 2013;Elia et al, 2017;Hossain et al, 2021). The inhibition of AChE activity as a sh response to persistent organic pollutants is quite extensively described (Silva et al, 2013;Mijošek et al, 2019), while data about metal-caused changes in AChE enzyme activity after exposure to various metals or their mixtures are scant.…”

Section: Introductionmentioning

confidence: 99%

“…The combined assessment of several biomarkers enables a more detailed identi cation of the targets of tested chemical stressors and the prediction of ecological risk to the environment (Mijošek et al, 2019;Hossain et al, 2021). The determination of biomarkers such as oxidative stress (CAT) and neurotoxicity (AChE) in sh is a useful instrument for the measuring response resulting from disruption of the biochemical balance of organisms following a variety of stressors (Alak et Towards the assessment of the cumulative effects of metal mixtures that re ect natural multicomponent environment conditions, and to predict the toxic impact of trace metals on freshwater organisms, metal concentrations were selected that were equal to or lower than the maximum permissible concentrations (MPC) accepted for inland waters in the EU (2013/39/EB; 2008/105/EB) and thereafter incorporated into tested metal mixtures.…”

Section: Introductionmentioning

confidence: 99%

“…They found that AChE was inhibited after 24 h of exposure to Cd (0.5 mg L -1 ), and no signi cant inhibition of AChE activity was noticed after 2 and 4 h of Cd (0.5 mg L -1 ) exposure in the white muscle of Sparus aurata. Also, signi cant AChE activity inhibition in the brain of the control group of Oreochromis niloticus was observable after 10 days of exposure with Buriganga River (Bangladesh) water polluted with heavy metals (Zn, Pb, Cd, Cr, Fe and Cu), whilst CAT activity was signi cantly increased in comparison to the control(Hossain et al, 2021). Romani with co-authors (2003) determined increased AChE activity in S. aurata brain and white muscle after 20 days of exposure to a sublethal concentration of Cu (0.1 or 0.5 mg L -1 ).…”

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confidence: 99%

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Response of Oxidative Stress and Neurotoxicity Biomarkers in Rainbow Trout (Oncorhynchus Mykiss) After Exposure to Six-Metal Mixtures

Nalivaikienė

Kalcienė

Butrimavičienė

2023

Preprint

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The activity of liver catalase (CAT) and brain acetylcholinesterase (AChE) was assessed in rainbow trout (Oncorhynchus mykiss) after 7- and 14-day exposure to a six-metal mixture at the maximum permissible concentrations (MPC) accepted for inland waters in the EU (2013/39/EB; 2008/105/EB) (Zn – 0.1, Ni – 0.034, Cu – 0.01, Cr – 0.01, Cd – 0.0015 and Pb – 0.014 mg L-1) (Mix) and to the same six-metal mixtures with tenfold reduced concentration of Cu (Mix Cu↓) and Cr (Mix Cr↓) ions. A statistically significant increase of up to 26% of CAT and 52% of AChE activity was observed in rainbow trout after 7 days of exposure to the six-metal mixture at MPC in comparison to a control group. After 14 days of treatment, neither CAT nor AChE showed a significant response. Moreover, 7 and 14 days of exposure to the six-metal mixtures with the tenfold reduced concentrations of Cr or Cu ions did not significantly alter CAT activity. The six-metal mixture with the tenfold reduced concentration of Cr increased brain AChE activity in O. mykiss after 7 days of exposure (35%), but did not show a significant response in AChE activity in comparison to a control group after 14 days of treatment. After 7 and 14 days of exposure to the six-metal mixture with the tenfold reduced concentration of Cu ions, AChE activity did not vary significantly in comparison to control groups. Enhancement of catalase activity caused by the mixture of the six metals at MPC and the increased AChE activity in response to the same metal mixture and mixture with tenfold reduced Cr concentration after 7 days of exposure indicates the induction of oxidative stress and disturbance of cholinergic system homeostasis respectively.

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