Toxicity of Hydrocarbons found in the Distillable Products

Akiya, Toshimi; Shimizu, Taeko

doi:10.5650/jos1956.14.520

Cited by 2 publications

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“…However, the absolute amounts of the nalkanes administered were extremely small, and it is impossible to estimate the capacity of these animals to oxidize n-alkanes. Hydrocarbons in large quantity (15-20% of total food intake) are toxic and cause death of weanling rats (Akiya & Shimizu, 1965). At present no information is available on the ability of higher animals to metabolize the branched-chain hydrocarbons.…”

mentioning

confidence: 99%

Lipid composition of human serum lipoproteins

Skipski¹,

Barclay²,

Barclay³

et al. 1967

Biochemical Journal

301

133

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1. The lipid compositions of the low-density lipoproteins, the high-density lipoproteins and the ultracentrifugal residue of human serum are presented, with emphasis on certain lipoprotein classes and lipid components not previously described. 2. Except for the lipoproteins with the lowest and highest densities, there is a trend for stepwise successive increase or, respectively, decrease in the relative amounts of the main constituents of lipoproteins. 3. High-density lipoprotein-2 and high-density lipoprotein-3 have different amounts of certain lipids; high-density lipoprotein-2 has relatively more free cholesterol and sphingomyelin; high-density lipoprotein-3 has more free fatty acids, diglycerides and ceramide monohexosides. 4. All the lipoproteins contain hydrocarbons of the alkane series. The greatest amount, which averages 4.4% of total lipid extracted, is in the ultracentrifugal residue; n-alkanes comprise 18-50% of the hydrocarbons. 5. All the lipoproteins contain ceramide monohexosides. The highest relative contents of these glycolipids are in high-density lipoprotein-3 and in the ultracentrifugal residue. 6. The ultracentrifugal residue contains 55% of the total quantity of free fatty acids present in serum. The remaining free fatty acids are distributed among the other lipoprotein classes. 7. The choline-containing phospholipids (phosphatidylcholine, lysophosphatidylcholine and sphingomyelin) comprise about 90% of the phospholipids in all the lipoprotein classes except the low-density lipoprotein-2, which contains about 80% of these phospholipids. 8. The presence of a large amount of lysophosphatidylcholine in the ultracentrifugal residue and the successive decrease of sphingomyelin from the low-density lipoprotein-1 to the ultracentrifugal residue was confirmed. 9. The low-density lipoprotein-2 and the ultracentrifugal residue are characterized by relatively high contents of the lower glycerides.

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mentioning

confidence: 99%

Lipid composition of human serum lipoproteins

Skipski¹,

Barclay²,

Barclay³

et al. 1967

Biochemical Journal

301

133

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show abstract

“…Gas chromatographic analysis of the neutral fraction showed that it was a mixture of hydrocarbons having various carbon chain lengths, and therefore the toxicity of appropriate hydrocarbons was investigated (14). Unex- pectedly, hydrocarbons with less than nine carbon atoms were not toxic, whereas hydrocarbons having more than ten carbon atoms depressed growth.…”

Section: Toxicity Of Fission Productsmentioning

confidence: 99%

Novel methods for evaluating deterioration and nutritive value of oxidized oil

Akiya

Araki

Igarashi

1973

Lipids

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The peroxide content of an oxidized oil is of limited value in estimating the toxicity of the oil, because some decomposition products of peroxides are also injurious to health. Methods of evaluating the toxicity of deteriorated fats and oils have been investigated. A method based on the mortality of chicken embryos following injection of oil into the yolk sac has been found to be much more sensitive and reproducible than tests based on growth rate of weanling rats or mice fed deteriorated oils. An enzyme activity method using alkaline phosphatase has been tested and gives promise of being very rapid, but additional work is required to evaluate this method and to look for better enzyme systems.

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Toxicity of Hydrocarbons found in the Distillable Products

Cited by 2 publications

References 0 publications

Lipid composition of human serum lipoproteins

Lipid composition of human serum lipoproteins

Novel methods for evaluating deterioration and nutritive value of oxidized oil

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