Toxicity of inorganic arsenic to animals and its treatment strategies

Qian, Shijun; He, Yuehui; Pan, Hemin; Liu, Haiyan; Mehmood, Khalid; Tang, Zhaoxin; Hu, Lianmei

doi:10.1016/j.cbpc.2023.109654

Cited by 25 publications

(3 citation statements)

References 65 publications

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“…3,4 Acute As poisoning in humans can lead to seizures and shock, and chronic As exposure may result in dermatosis, chronic liver disease, cancer, and other adverse health effects. 5,6 Owing to geothermal activities, As has been present in the earth's environment before the emergence of life. Its pervasive existence exerts substantial and enduring pressure on the evolution of cellular detoxification mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…The metalloid arsenic (As) has two biologically relevant oxidation states: arsenite [As(III)] and arsenate [As(V)]. , As poses a severe threat to plants, animals, and humans and is derived from natural phenomena (such as weathering and volcanic eruptions) and anthropogenic activities (such as industrial wastewater discharge and ore mining). , Acute As poisoning in humans can lead to seizures and shock, and chronic As exposure may result in dermatosis, chronic liver disease, cancer, and other adverse health effects. , Owing to geothermal activities, As has been present in the earth’s environment before the emergence of life. Its pervasive existence exerts substantial and enduring pressure on the evolution of cellular detoxification mechanisms. − A large number of bacterial strains possess genes associated with As metabolism ( ars operon), and numerous fungal, algal, and vertebrates also possess these genes. , The ars operon functions as a protective mechanism against As toxicity in the cell.…”

Section: Introductionmentioning

confidence: 99%

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Arsenite Mediates Selenite Resistance and Reduction in Enterobacter sp. Z1, Thereby Enhancing Bacterial Survival in Selenium Environments

Lan,

Luo,

Fan

et al. 2024

Environ. Sci. Technol.

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Arsenic (As) is widely present in the environment, and virtually all bacteria possess a conserved ars operon to resist As toxicity. High selenium (Se) concentrations tend to be cytotoxic. Se has an uneven regional distribution and is added to mitigate As contamination in Se-deficient areas. However, the bacterial response to exogenous Se remains poorly understood. Herein, we found that As(III) presence was crucial for Enterobacter sp. Z1 to develop resistance against Se(IV). Se(IV) reduction served as a detoxification mechanism in bacteria, and our results demonstrated an increase in the production of Se nanoparticles (SeNPs) in the presence of As(III). Tandem mass tag proteomics analysis revealed that the induction of As(III) activated the inositol phosphate, butanoyl-CoA/dodecanoyl-CoA, TCA cycle, and tyrosine metabolism pathways, thereby enhancing bacterial metabolism to resist Se(IV). Additionally, arsHRBC, sdr-mdr, purHD, and grxA were activated to participate in the reduction of Se(IV) into SeNPs. Our findings provide innovative perspectives for exploring As-induced Se biotransformation in prokaryotes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Arsenite Mediates Selenite Resistance and Reduction in Enterobacter sp. Z1, Thereby Enhancing Bacterial Survival in Selenium Environments

Lan,

Luo,

Fan

et al. 2024

Environ. Sci. Technol.

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“…Arsenic (As) is widely distributed in nature, and is absorbed through the food chain and bioaccumulation, leading to the formation of various arsenic species in organisms through methylation. Among all arsenic species, inorganic arsenic (iAs), including arsenite (AsIII) and arsenate (AsV), is the most toxic form, and long-term exposure to low levels of iAs can cause cancer and other health hazards to in humans [ 1 , 2 ]. The genetic toxicity of iAs metabolites, such as monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), is much lower.…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of Arsenic on Four Freshwater Aquatic Species and Its Transformation Metabolism in Crucian Carp (Carassius auratus)

Tang,

Gao,

Qin

et al. 2024

Toxics

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Inorganic arsenic is a well-known carcinogen that is much more toxic than its organic counterpart. While much is known about the accumulation and transformation of arsenic in marine organisms, little is known regarding these processes in freshwater aquatic species. In this study, the acute toxicity and toxicological effects of inorganic arsenic on four freshwater organisms (Cyprinus carpio, Misgurnus anguillicaudatus, Pseudorasbora parva, Eriocheir sinensis) commonly found in rice-fish farming systems were investigated. The organisms exhibited different levels of sensitivity to inorganic arsenic, with crustaceans being more sensitive than fish. Fish were found to be more tolerant to As(V) than As(III). The study also investigated the accumulation, transformation, and release of inorganic arsenic in crucian carp, an omnivorous species with high environmental tolerance. The fish accumulated As(III) rapidly in various tissues, and were able to transport it to other tissues through gills, intestines, and skin. The accumulated As(III) was converted into less toxic forms, such as monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), via methylation. The fish also converted As(III) into arsenate (AsV) via enzymatic and oxidative reactions. After the transferal to clean water, the forms of arsenic in the various tissues decreased rapidly, but the rates of excretion of the four forms of arsenic were not the same among the different tissues. Our results suggest that crucian carp can reduce the environmental toxicity of As(III) at certain concentrations by transforming it into less toxic forms within their bodies.

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Ameliorative potential of betaine against arsenite-induced hepatotoxicity and nephrotoxicity

al-Hafyan,

Asoodeh,

Baghshani

et al. 2023

Comp Clin Pathol

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Toxicity of inorganic arsenic to animals and its treatment strategies

Cited by 25 publications

References 65 publications

Arsenite Mediates Selenite Resistance and Reduction in Enterobacter sp. Z1, Thereby Enhancing Bacterial Survival in Selenium Environments

Arsenite Mediates Selenite Resistance and Reduction in Enterobacter sp. Z1, Thereby Enhancing Bacterial Survival in Selenium Environments

Toxic Effects of Arsenic on Four Freshwater Aquatic Species and Its Transformation Metabolism in Crucian Carp (Carassius auratus)

Ameliorative potential of betaine against arsenite-induced hepatotoxicity and nephrotoxicity

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